[1]曹 明 洪 洋 侯保森 刘兴瑞 李庆新 徐培坤.颅内转移瘤X刀立体定向放射治疗后生存期的影响因素分析[J].中国临床神经外科杂志,2019,(08):495-497.[doi:10.13798/j.issn.1009-153X.2019.08.016]
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颅内转移瘤X刀立体定向放射治疗后生存期的影响因素分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年08期
页码:
495-497
栏目:
论著
出版日期:
2019-08-25

文章信息/Info

文章编号:
1009-153X(2019)08-0495-03
作者:
曹 明 洪 洋 侯保森 刘兴瑞 李庆新 徐培坤
230000 合肥,安徽医科大学第一附属医院神经外科(曹 明、洪 洋、侯保森、刘兴瑞、李庆新、徐培坤)
关键词:
颅内转移瘤X刀立体定向放射治疗生存期影响因素
分类号:
R 739.41; R 815.2
DOI:
10.13798/j.issn.1009-153X.2019.08.016
文献标志码:
B
摘要:
目的 探讨颅内转移瘤病人X刀立体定向放射治疗后生存期的影响因素。方法 回顾性分析2005年1月至2016年12月X刀立体定向放射治疗的51例颅内转移瘤的临床资料,采用Kaplan-Meier法分析治疗后生存期,采用Cox比例风险回归模型分析生存期的影响因素。结果 51例颅内转移瘤的中位生存期为13个月。单因素分析结果显示年龄≥55岁、治疗前KPS评分≥70分病人生存期明显延长(P<0.05),多因素Cox比例风险回归模型分析结果示KPS评分≥70分的病人治疗后生存时间明显延长。结论 治疗前KPS评分与生存期有关,同时应考虑病人接受治疗的意愿,以及颅内转移瘤治疗方式的多元化,应根据病人病情及肿瘤来源、性质选择个体化治疗。

参考文献/References:

[1] Lin X, DeAngelis LM. Treatment of brain metastasis [J]. J Clin Oncol, 2015, 33(30): 3475-3484. [2] Prabhu RS, Press RH, Patel KR, et al. Single-fraction ste- reotactic radiosurgery (SRS) alone versus surgical resection and SRS for large brain metastases: a multi-institutional analysis [J]. Int J Radiat Biol Phys, 2017, 99(2): 459-467. [3] 朱 虹,吕 博,李云海,等. 脑转移瘤放射治疗的预后因 素分析及预后模型的建立[J]. 中国癌症杂志,2014,24 (6):457-462. [4] Bennett EE, Angelov L, Vogelbaum MA, et al. The prognos- tic role of tumor volume in the outcome of patients with single brain metastasis after stereotactic radiosurgery [J]. World Neurosurg, 2017, 104: 229-238. [5] Chang WS, Kim HY, Chang JW, et al. Analysis of radiosur- gical results in patients with brain metastases according to the number of brain lesions: is stereotactic radiosurgery effrctive for multiple brain metastases [J]. J Neurosurg, 2010, 113: 73-78. [6] Siena S, Crinò L, Danova M, et al. Dose-dense temozolo- mide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase Ⅱ study [J]. Ann Oncol, 2010, 21: 655-661. [7] Hardee ME. Combining stereotactic radiosurgery and systemic therapy for brain metastases: a potential role for temozolomide [J]. Front Oncol, 2012, 2: 99. [8] Hashimoto K, Narita Y, Matsusshita Y, et al. Methylation status of O6-methylguanine-DNA-methyl transferase pro- moter region in non-small-cell lung cancer patients with brain metastasis [J]. Clin Transl Oncol, 2012, 14: 31-35. [9] Wu PF, Kuo KT, Kuo LT, et al. O(6)-Methylguanine-DNA methyltransferase expression and prognostic value in brain metastases of lung cancers [J]. Lung Cancer, 2010, 68: 484- 490. [10] Rades D, Hornung D, Veninga T, et al. Single brain meta- stasis: radiosurgery alone compared with radiosurgery plus up-front whole-brain radiotherapy [J]. Cancer, 2012, 118 (11): 2980-2985. [11] Brown PD, Jaeckle K, Ballman KV, et al. Effect of radiosur- gery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial [J]. JAMA, 2016, 316 (4): 401-409. [12] Deng X, Zheng Z, Lin B, et al. The efficacy and roles of combining temozolomide with whole brain radiotherapy in protection neurocognitive function and improvement quality of life of non-small-cell lung cancer patients with brain metastases [J]. BMC Cancer, 2017, 17(1): 42. [13] Liu HP, Zheng KB. Efficacy and safety of temozolomide plus whole-brain radiotherapy in the treatment of intracra- nial metastases [J]. J Cancer Res Ther, 2017, 13: 785-789. [14] Koba T, Kijima T, Takimoto T, et al. Rapid intracranial response to osimertinib, without radiotherapy, in nonsmall cell lung cancer patients harboring the EGFR T790M mutation: two case report [J]. Medicine, 2017, 96: e6087. [15] Ahluwalia MS, Chao ST, Parsons MW, et al. Phase Ⅱ trial of sunitinib as adjuvant therapy after stereotactic radiosur- gery in patients with 1-3 newly diagnosed brain metastases [J]. J Neurooncol, 2015, 124 (3): 485-491. [16] Kaidar-Person O, Zagar TM, Deal A, et al. The incidence of radiation necrosis following stereotactic radiotherapy for melanoma brain metastases: the potential impact of immu- notherapy [J]. Anti-cancer Drugs, 2017, 28(6): 669-675.

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备注/Memo

备注/Memo:
(2018-06-12收稿,2018-09-27修回)
更新日期/Last Update: 2019-08-25