[1]余永佳　梁　伦　黄　玮　王圣泳　王春喜　石　琦.颅内肿瘤术后凝血功能障碍的危险因素分析[J].中国临床神经外科杂志,2020,(12):828-830.[doi:10.13798/j.issn.1009-153X.2020.12.004]
　YU Yong-jia,LIANG Lun,HUANG Wei,et al.Analysis of risk factors of coagulopathy in patients with intracranial tumor after tumor resection[J].,2020,(12):828-830.[doi:10.13798/j.issn.1009-153X.2020.12.004]
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颅内肿瘤术后凝血功能障碍的危险因素分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年12期
页码:
828-830
栏目:
论著
出版日期:
2020-12-25

文章信息/Info

Title:
Analysis of risk factors of coagulopathy in patients with intracranial tumor after tumor resection
文章编号:
1009-153X（2020）12-0828-03
作者:
余永佳　梁　伦　黄　玮　王圣泳　王春喜　石　琦
530021 南宁，广西医科大学第一附属医院神经外科（余永佳、黄　玮、王圣泳、王春喜、石　琦）；510060 广州，中山大学肿瘤防治中心神经外科、华南肿瘤学国家重点实验室（梁　伦）
Author(s):
YU Yong-jia1;  LIANG Lun2;  HUANG Wei1;  WANG Sheng-yong1;  WANG Chun -xi1;  Shi Qi1.
1. Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China; 2. Department of Neurosurgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
关键词:
颅内肿瘤; 显微手术; 凝血功能障碍; 影响因素
Keywords:
Intracranial tumors;  Microsurgery;  Coagulation dysfunction;  Influencing factors
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2020.12.004
文献标志码:
A
摘要:
目的 探讨颅内肿瘤术后凝血功能障碍的危险因素。方法 回顾性分析2016年1月至2018年12月手术治疗的106例颅内肿瘤的临床资料。结果 156 例中，术后发生凝血功能障碍50例，术后凝血功能正常106例。多因素logistics回归分析显示，术后低体温、术后低钙血症和输注红细胞过多是颅内肿瘤术后凝血功能障碍的独立危险因素（P<0.05）。凝血功能障碍组术后颅内血肿发生率（64.0%，32/50）较凝血功能正常组（17.9%，19/106）明显增高（P<0.05）。术后6个月，凝血功能障碍组GOS评分5分25例，4分17例，3分4例，2分4例；凝血功能正常组GOS评分5分81例，4分20例，3分3例，2分1例，1分1例；凝血功能正常组GOS评分明显优于凝血功能障碍组（P<0.05）。结论 颅内肿瘤术后发生凝血功能障碍影响预后，避免术中输注过多红细胞、术后及时复查血钙浓度、体温并及时处理，有助于预防术后凝血功能障碍。
Abstract:
Objective To investigate the risk factors of coagulopathy in the patients with intracranial tumor after tumor resection.Methods The clinical data of 106 patients with intracranial tumor who underwent surgery from January 2016 to December 2018 were retrospectively analyzed. Results Of 156 patients, 50 had coagulopathy after the operation and 106 did not. Multivariate logistic regression analysis showed that postoperative hypothermia, postoperative hypocalcemia and excessive red blood cell infusion were independent risk factors for coagulation dysfunction after intracranial tumor surgery (P<0.05). The incidence of postoperative intracranial hematoma in the coagulopathy group (64.0%, 32/50) was significantly higher than that (17.9%, 19/106) in the normal coagulation group (P<0.05). The GOS score of the coagulation dysfunction group was significantly lower than that of the normal coagulation function group 6 months after the operation (P<0.05). Conclusions Postoperative coagulopathy has an adverse effect on the patients’ prognosis. Avoiding excessive red blood cell transfusion during the surgery, timely monitoring of blood calcium and body temperature and timely treatment can help prevent postoperative coagulation dysfunction.

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备注/Memo

备注/Memo:
基金项目：广西卫生健康委员会适宜技术项目（S2018013）通讯作者：梁　伦，E-mail：18277186779@163.com
更新日期/Last Update: 2020-12-25