[1]吴珠,杨生长,陈力.AQP-4、VEGF表达与脑膜瘤术后脑水肿加重的相关性分析[J].中国临床神经外科杂志,2022,27(05):363-365.[doi:10.13798/j.issn.1009-153X.2022.05.009]
　WU Zhu,YANG Sheng-chang,CHEN Li.Correlation between expressions of AQP-4 and VEGF and postoperative cerebral edema exacerbation in patients with meningioma[J].,2022,27(05):363-365.[doi:10.13798/j.issn.1009-153X.2022.05.009]
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AQP-4、VEGF表达与脑膜瘤术后脑水肿加重的相关性分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年05期
页码:
363-365
栏目:
论著
出版日期:
2022-05-31

文章信息/Info

Title:
Correlation between expressions of AQP-4 and VEGF and postoperative cerebral edema exacerbation in patients with meningioma
文章编号:
1009-153X(2022)05-0363-03
作者:
吴珠; 杨生长; 陈力
572600海南，东方市人民医院神经外科（吴珠、杨生长、陈力）
Author(s):
WU Zhu ; YANG Sheng-chang;  CHEN Li
Department of Neurosurgery, DongfangPeople's Hospital, Dongfang 572600, China
关键词:
脑膜瘤; 术后脑水肿; 显微手术; 水通道蛋白4; 血管内皮生长因子
Keywords:
Meningiomas;  Aquaporin 4;  Vascular endothelial growth factor;  Postoperative cerebral edema
分类号:
R739.41;Q786
DOI:
10.13798/j.issn.1009-153X.2022.05.009
文献标志码:
A
摘要:
目的 探讨水通道蛋白4（AQP-4）、血管内皮生长因子（VEGF）表达与脑膜瘤术后脑水肿加重的相关性。方法 收集2019年1月至2020年1月手术切除并经术后病理确诊的脑膜瘤组织105例，免疫组化染色检测AQP-4和VEGF的表达。术后2~15 d复查头部MRI判断脑水肿。结果 105例中，术后脑水肿加重30例（28.57%），未加重75例。术后脑水肿加重组AQP-4阳性表达率（63.3%）和VEGF阳性表达率（30.0%）较未加重组明显增加（分别为30.7%和16.0%；P<0.05）。多因素logistic回归分析显示，AQP-4和VEGF阳性表达是脑膜瘤术后脑水肿加重的独立危险因素（P<0.05）。结论 AQP-4和VEGF表达上调与脑膜瘤术后脑水肿加重有关。
Abstract:
Objective To investigate the correlation between the expressions of aquaporin 4 (AQP-4) and vascular endothelial growth factor (VEGF) and the aggravation of postoperative cerebral edema in the patients with meningioma. Methods The expressions of AQP-4 and VEGF were detected by immunohistochemical staining in meningioma tissues obtained from 105 patients who underwent microsurgery from January 2019 to January 2020. The aggravation of postoperative peritumoral edema was detected by head MRI 2~15 days after operation. Results The aggravation of postoperative cerebral edema occurred in 30 patients (28.57%; edema group) of 105 patients, and did not in 75 patients (non-edema group). The positive expression rates of AQP-4 (63.3%) and VEGF (30.0%) in edema group were significantly higher than those (30.7% and 16.0%, respectively) in non-edema group (P<0.05). Multivariate logistic regression analysis showed that the positive expressions of AQP-4 and VEGF were independent risk factors for the aggravation of postoperative cerebral edema (P<0.05). Conclusions The up-regulation of AQP-4 and VEGF in meningioma tissue is related to the aggravation of postoperative cerebral edema in the patients with meningioma.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：海南省卫生计生行业科研项目（18A200112）
更新日期/Last Update: 2022-06-30