[1]熊　坤　冷　彪　程世奇等.特发性正常压力脑积水脑脊液标志物的变化[J].中国临床神经外科杂志,2021,26(03):162-164.[doi:10.13798/j.issn.1009-153X.2021.03.006]
　XIONG Kun,LENG Biao,CHENG Shi-qi,et al.Changes of cerebrospinal fluid markers in patients with idiopathic normal pressure hydrocephalus[J].,2021,26(03):162-164.[doi:10.13798/j.issn.1009-153X.2021.03.006]
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特发性正常压力脑积水脑脊液标志物的变化()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年03期
页码:
162-164
栏目:
论著
出版日期:
2021-03-25

文章信息/Info

Title:
Changes of cerebrospinal fluid markers in patients with idiopathic normal pressure hydrocephalus
文章编号:
1009-153X（2021）03-0162-03
作者:
熊　坤　冷　彪　程世奇等
510510 广州，广东三九脑科医院神经外科（熊　坤）；330006 南昌，南昌大学第二附属医院神经外科（冷　彪、程世奇、袁饶饶、王　兵、卓　毅、张　焱）；330031 南昌，南昌大学医学部医学实验教学中心（张　苗）
Author(s):
XIONG Kun;  LENG Biao;  CHENG Shi-qi;  et al
1.Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou 510510, China; 2. Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 3. Department of Medical Experimental Teaching, Medical College, Nanchang University, Nanchang 330031, China
关键词:
特发性正常压力脑积水; 脑脊液; 生物标志物; tau蛋白; 转化生长因子-β1; 分流术
Keywords:
Idiopathic normal pressure hydrocephalus;  Cerebrospinal fluid;  Tau protein;  transforming growth factor β1;  Shunt
分类号:
R 742.7
DOI:
10.13798/j.issn.1009-153X.2021.03.006
文献标志码:
A
摘要:
目的 探讨特发性正常压力脑积水（iNPH）病人脑脊液（CSF）磷酸化tau蛋白（p-tau）、总tau蛋白（t-tau）、转化生长因子-β1（TGF-β1）的变化。方法 前瞻性收集2018年6月至2020年2月经分流术临床确诊的16例iNPH为确诊组，同期行脑脊液释放试验无效的16例可疑iNPH为可疑组。采用酶联免疫吸附试验检测CSF中p-tau、t-tau、TGF-β1水平。结果 确诊组CSF中p-tau水平显著低于可疑组（P<0.01），TGF-β1水平显著高于可疑组（P<0.01）。两组CSF中t-tau水平无统计学差异（P>0.05）。8例确诊iNPH术后7 d的CSF中p-tau、t-tau水平较术前均明显降低（P<0.05），而TGF-β1水平与术前无统计学差异（P>0.05）。结论 本文结果提示CSF中p-tau、t-tau、TGF-β1在iNPH诊断、分流术效果评估中具有一定的作用。
Abstract:
Objective To investigate the changes of cerebrospinal fluid (CSF) markers including phosphorylated tau protein (p-tau), total tau protein (t-tau), and transforming growth factor β1 (TGF-β1) in the patients with idiopathic normal pressure hydrocephalus (iNPH). Methods Sixteen patients with iNPH who were clinically diagnosed by shunt operation (observation group) and 16 patients who were suspected with iNPH and negative outcome of CSF tap test (control group) were prospectively recruited from June 2018 to February 2020. Enzyme-linked immunosorbent assay was used to detect the levels of CSF p-tau, t-tau and TGF-β1. Results The level of CSF p-tau of the observation group was significantly lower than that of the control group (P<0.01), and the level of CSF TGF-β1 of the observation group was significantly higher than that of the control group (P<0.01). There was no statistical difference in the level of CSF t-tau between the two groups (P>0.05). The levels of CSF p-tau and t-tau of 8 patients in the observation group 7 days after the shunt operation were significantly lower than those before the operation (P<0.05), while the level of CSF TGF-β1 was not significantly different from that before the operation (P>0.05). Conclusions Our results suggest that the CSF p-tau, t-tau and TGF-β1 may be of certain value in the diagnosis and the outcome evaluation of shunt operation for the patients with iNPH.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：张　焱，E-mail：doctorzhangyan@163.com
更新日期/Last Update: 2021-03-25