[1]刘　磊　刘　坤　徐国政.血栓弹力图监测颅脑损伤病人凝血功能的临床价值[J].中国临床神经外科杂志,2021,26(03):170-172.[doi:10.13798/j.issn.1009-153X.2021.03.009]
　LIU Lei,LIU Kun,XU Guo-zheng.Clinical value of thromboelastography in monitoring of coagulation function in patients with traumatic brain injury[J].,2021,26(03):170-172.[doi:10.13798/j.issn.1009-153X.2021.03.009]
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血栓弹力图监测颅脑损伤病人凝血功能的临床价值()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年03期
页码:
170-172
栏目:
论著
出版日期:
2021-03-25

文章信息/Info

Title:
Clinical value of thromboelastography in monitoring of coagulation function in patients with traumatic brain injury
文章编号:
1009-153X（2021）03-0170-03
作者:
刘　磊　刘　坤　徐国政
430070 武汉，中国人民解放军中部战区总医院输血科（刘　磊），科训科（刘 坤），神经外科（徐国政）
Author(s):
LIU Lei;  LIU Kun;  XU Guo-zheng
1.Department of Transfusion, General Hospital of Central Theater Command, PLA, Wuhan 430070, China; 2. Department of Scientific Research and Training, General Hospital of Central Theater Command, PLA, Wuhan 430070, China; 3. Department of Neurosurgery, General Hospital of Central Theater Command, PLA, Wuhan 430070, China
关键词:
颅脑损伤; 血栓弹力图; 凝血功能
Keywords:
Traumatic brain injury;  Coagulation function;  Thromboelastography
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2021.03.009
文献标志码:
A
摘要:
目的 探讨血栓弹力图（TEG）监测颅脑损伤（TBI）病人凝血功能的临床意义。方法 回顾性分析2017年1月至2019年12月收治的108例TBI的临床资料。按入院GCS评分分为轻型组（58例）、中型组（24例）、重型组（26）。分析TEG参数[主要包括凝血反应时间（R值）、凝血形成时间（K值）、凝固角（α值）、血栓最大振幅（MA值）]与常规凝血功能检查指标的关系。结果 与轻、中型组比较，重型组凝血酶原时间（PT）显著延长（P<0.05），纤维蛋白原（Fg）含量显著升高（P<0.05）。相关性分析显示，PT与R值呈正相关（P<0.05）；活化部分凝血活酶时间与R值、MA值均呈正相关（P<0.05）；Fg与K值呈负相关（P<0.05），与α角和MA值均呈正相关（P<0.05）；凝血酶时间与K值呈正相关（P<0.05），与R值、α角和MA值均呈负相关（P<0.05）；血小板计数与K值呈负相关（P<0.05），与α角和MA值均呈正相关（P<0.05）。结论 TEG监测TBI病人凝血功能，能够准确反映机体的真实凝血全貌。
Abstract:
Objective To explore the value of thromboelastography (TEG) in the monitoring of coagulation function in the patients with traumatic brain injury (TBI). Methods The clinical data of 108 patients with TBI who were treated in Department of Neurosurgery of our hospital from January 2017 to December 2019 were analyzed retrospectively. The relationship between TEG parameters [including coagulation reaction time (R value), coagulation formation time (K value), coagulation angle (α value), and maximum amplitude of thrombus (MA value)] and routine coagulation function examination indexes were analyzed. Results Of 108 TBI patients, 58 patients were mild TBI (mild group), 24 moderate TBI (mederate group) and 26 severe TBI (severe group). The prothrombin time (PT) significantly prolonged (P<0.05), and the fibrinogen (Fg) content significantly increased (P<0.05) in the severe group compared with the mild and moderate groups. Correlation analysis showed that PT was positively correlated with R value (P<0.05); activated partial thromboplastin time was positively correlated with R value and MA value (P<0.05); Fg was negatively correlated with K value (P<0.05), positively correlated with α angle and MA value (P<0.05); thrombin time was positively correlated with K value (P<0.05), and negatively correlated with R value, α angle and MA value (P<0.05) ; platelet count was negatively correlated with K value (P<0.05), and positively correlated with α angle and MA value (P<0.05). Conclusions TEG has great clinical significance in the monitoring of coagulation function of the TBI patients, and it can provide an accurate and real-time picture of whole blood coagulation in the TBI patients.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：徐国政，E-mail：xu-gz@163.com
更新日期/Last Update: 2021-03-25