[1]胡海斌,王湘,周辉,等.入院NLR与外伤性脑内血肿扩大及病人预后的关系[J].中国临床神经外科杂志,2022,27(06):464-467.[doi:10.13798/j.issn.1009-153X.2022.06.010]
　HU Hai-bin,WANG Xiang,ZHOU Hui,et al.Association of admission NLR with hematoma expansion and 3-month prognosis of patients with traumatic intracerebral haemorrhage[J].,2022,27(06):464-467.[doi:10.13798/j.issn.1009-153X.2022.06.010]
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入院NLR与外伤性脑内血肿扩大及病人预后的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年06期
页码:
464-467
栏目:
论著
出版日期:
2022-06-30

文章信息/Info

Title:
Association of admission NLR with hematoma expansion and 3-month prognosis of patients with traumatic intracerebral haemorrhage
文章编号:
1009-153X(2022)06-0464-04
作者:
胡海斌; 王湘; 周辉; 蒋伟
638001 四川，广安市人民医院神经外科（胡海斌、王湘、周辉、蒋伟）
Author(s):
HU Hai-bin;  WANG Xiang;  ZHOU Hui;  JIANG Wei
Department of Neurosurgery, Guang'an People's Hospital, Guang'an 638001, China
关键词:
颅脑损伤; 外伤性脑出血; 中性粒细胞/淋巴细胞比值; 血肿扩大; 预后; 危险因素
Keywords:
Traumatic intracerebral hemorrhage;  Neutrophil/lymphocyte ratio;  Hematoma expansion;  Prognosis
分类号:
R651.1+5
DOI:
10.13798/j.issn.1009-153X.2022.06.010
文献标志码:
A
摘要:
目的 探讨入院中性粒细胞/淋巴细胞比值（NLR）与外伤性脑出血（tICH）血肿扩大及病人预后的相关性。方法 2019年7月至2021年8月前瞻性收集tICH病人共115例。根据入院血常规计算NLR。伤后3个月，根据改良Rankin量表评分评估预后，0~2分为预后良好。血肿扩大定义为二次CT扫描与基线CT扫描相比体积增加33%或>5 ml。结果 115例中，13例（11.30%）发生血肿扩大。伤后3个月，41例（35.65%）预后不良，74例（64.35%）预后良好。多因素logistic回归分析显示，血肿扩大以及入院NLR水平增高为tICH病人预后不良的独立危险因素（P<0.05），入院NLR水平增高是血肿扩大的独立危险因素（P<0.001）。ROC曲线分析显示，入院NLR水平评估血肿扩大的AUC为0.896（95% CI 0.821~0.971；P<0.001），入院NLR水平评估tICH病人伤后3个月预后不良的曲线下面积为0.709（95% CI 0.615~0.802；P<0.05）。结论 tICH血肿扩大影响病人预后，神经炎症参与tICH进展。入院NLR对tICH血肿扩大、病人预后具有一定的评估价值。NLR临床极易获取，因此NLR是评估tICH病情的一个有价值的指标。
Abstract:
Objective To analyze the correlation between admission neutrophil/lymphocyte ratio (NLR) and hematoma expansion and 3-month prognosis of patients with traumatic intracerebral haemorrhage (tICH). Methods A total of 115 patients with tICH were prospectively recruited from July 2019 to August 2021. NLR was calculated based on the admission blood routine test. At 3 months post-injury, the prognosis was evaluated according to the modified Rankin scale, with a score of 0~2 as good prognosis. Hematoma enlargement was defined as a 33% or >5 ml increase in volume on the second CT scan compared to the baseline CT scan. Results Of 115 patients, 13 patients (11.30%) suffered from hematoma expansion. At 3 months after injury, 41 patients (35.65%) had poor prognosis and 74 (64.35%) had good prognosis. Multivariate logistic regression analysis showed that hematoma expansion and admission NLR increase were independent risk factors for poor prognosis of tICH patients (P<0.05), and admission NLR increase was an independent risk factor for hematoma expansion in tICH patients (P<0.001). ROC curve analysis showed that the AUC of the admission NLR level to assess the hematoma expansion was 0.896 (95% CI 0.821~0.971; P<0.001), and the AUC of the admission NLR level to assess the poor prognosis of tICH patients 3 months after injury was 0.709 (95% CI 0.615~0.802; P<0.05). Conclusions Hematoma expansion affects the prognosis of patients with tICH, and the neuroinflammation is involved in the progression of tICH. Admission NLR has a certain value in evaluating hematoma expansion and prognosis of patients with tICH. NLR is easily accessible clinically, so NLR is a valuable indicator for evaluating the condition of patients with tICH.

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备注/Memo

备注/Memo:
（2022-03-12收稿，2022-05-13修回）
更新日期/Last Update: 2022-07-31