[1]王作伟,张一可,菅凤增,等.寰枢椎关节间融合器的拓扑优化设计[J].中国临床神经外科杂志,2022,27(11):917-920.[doi:10.13798/j.issn.1009-153X.2022.11.011]
　WANG Zuo-wei,ZHANG Yi-ke,JIAN Feng-zeng,et al.Topology optimization design of atlantoaxial inter-articular cage[J].,2022,27(11):917-920.[doi:10.13798/j.issn.1009-153X.2022.11.011]
点击复制

寰枢椎关节间融合器的拓扑优化设计()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年11期
页码:
917-920
栏目:
实验研究
出版日期:
2022-11-30

文章信息/Info

Title:
Topology optimization design of atlantoaxial inter-articular cage
文章编号:
1009-153X（2022）11-0917-04
作者:
王作伟; 张一可; 菅凤增; 吴浩; 王兴文; 段婉茹; 王凯; 关健; 刘振磊; 陈赞
1100053 北京，首都医科大学宣武医院神经外科/中国国际神经科学研究所神经脊柱中心（王作伟、菅凤增、吴浩、王兴文、段婉茹、王凯、关健、刘振磊、陈赞）；116024 大连，大连理工大学工程力学系（张一可）
Author(s):
WANG Zuo-wei1;  ZHANG Yi-ke2;  JIAN Feng-zeng1;  WU Hao1;  WANG Xing-wen1;  DUAN Wan-ru1;  WANG Kai1;  GUAN Jian1;  LIU Zhen-lei1;  CHEN Zan1
1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University (Neurospine Center, China International Neuroscience Institute), Beijing 100530, China; 2. Department of Engineering Mechanics, Dalian University of Technology Dalian 116024, China
关键词:
颅颈交界区疾病; 寰枢椎融合术; 结构拓扑优化设计; 寰枢椎融合器
Keywords:
Craniocervical junction disease;  Atlantoaxial interarticular cage;  Structural topology optimization
分类号:
R681.5;R651
DOI:
10.13798/j.issn.1009-153X.2022.11.011
文献标志码:
A
摘要:
目的 探讨结构拓扑优化技术在寰枢椎关节间融合器设计的应用效果。方法 选择1名健康志愿者，进行寰枕交界部位CT扫描，建立寰枢椎三维几何模型；对寰枢椎内固定系统模型基于边界反演法进行材料参数反演，构建各向同性材料参数下的简化模型，采用变密度法对植骨窗部分进行拓扑优化设计，获得植骨窗体积最大且结构刚度满足要求的结构，并几何重构为新型寰枢椎侧块关节间融合器（Cage A）。模拟融合器植入，比较CageA与传统融合器（Cage B）植入后，椎体、融合器及植骨内部应力响应，对植入融合器和椎体力学响应进行评估。结果 与传统融合器（Cage B）相比，Cage A模型最大应力明显降低，且应力较均匀分布在支撑面上；在后伸状态下，植入Cage B的整体模型形变峰值明显降低；Cage B植入的椎体最大应力值、植骨体积占比无明显变化。结论 借助结构拓扑优化技术设计的寰枢椎关节间融合器，应力分布均匀，椎体受力小。该方法可以实现具有针对性的个体化融合器设计。
Abstract:
Objective To investigate the application value of topology optimization technology in the design of atlantoaxial interarticular cage. Methods Three dimensional model of atlantoaxial vertebrae was established by scanning CT in a healthy volunteer. Based on this simplified model, topology optimization design was carried out for the atlantoaxial interarticular cage device. A new atlantoaxial cage (Cage A) was designed through topology optimization. The internal stress responses of Cage A and the traditional cage to the vertebral body were compared, and the mechanical properties of the fusion apparatus were evaluated. Results Compared with the traditional cage, the maximum stress of Cage A model was significantly reduced, and the stress was evenly distributed on the support surface. In the posterior extension state, the deformation peak value of the overall model with Cage B was significantly reduced. There were no significant changes in the maximum stress value and the proportion of bone graft volume in the vertebrae implanted by Cage B. Conclusions Compared with the traditional cage, the atlantoaxial interarticular cage designed by topological optimization technology has a more uniform stress distribution and reduces the risk of fusion cage settlement. This method can realize individualized cage design.

参考文献/References:

[1] Salunke P, Karthigeyan M, Sahoo SK, et al. Improvise, adapt and overcome-challenges in management of pediatric congenital atlantoaxial dislocation [J]. Clin Neurol Neurosurg, 2018, 171: 85-94.
[2] Guan J, Chen Z, Wu H, et al. Effectiveness of posterior reduction and fixation in atlantoaxial dislocation: a retro-spective cohort study of 135 patients with a treatment algorithm proposal [J]. Eur Spine J, 2019, 28(5): 1053-1063.
[3] 马向阳，杨进城，邱　锋，等. 寰枢椎脱位后路植骨材料的选择与融合效果评价[J]. 中国骨科临床与基础研究杂志，2015，7（1）：5-9.
[4] 李松凯，倪　斌，张军华，等. 寰枢椎侧块关节融合器的研制及其生物力学研究[J]. 中华骨科杂志，2015，35（6）：656-662.
[5] Yoshizumi T, Murata H, Ikenishi Y, et al. Occipitocervical fusion with relief of odontoid invagination: atlantoaxial distraction method using cylindrical titanium cage for basilar invagination--case report [J]. Neurosurg Rev, 2014, 37(3): 519-524.
[6] Cheng KT, Olhoff N. An investigation concerning optimal design of solid elastic plate [J]. Int J Solids Struct, 1981, 17: 305-323.
[7] Bends?e MP, Kikuchi N. Generating optimal topologies in structural design using a homogenization method [J]. Com Meth Applied Mech Engin, 1988, 71: 197-224.
[8] Rozvany GIN. A critical review of established methods of structural topology optimization [J]. Struct Multidiscipl Optimiz, 2009, 37: 217-237.
[9] Goel A, Dhar A, Shah A, et al. Central or axial atlantoaxial dislocation as a cause of cervical myelopathy: a report of outcome of 5 cases treated by atlantoaxial stabilization [J]. World Neurosurg, 2019, 121: 908-916.
[10] Chen Z, Duan W, Chou D, et al. A safe and effective posterior intra-articular distraction technique to treat congenital atlantoaxial dislocation associated with basilar invagination: case series and technical nuances [J]. Oper Neurosurg (Hagerstown), 2021, 20(4): 334-342.
[11] Zhang WS, Yuan J, Zhang J, et al. A new topology optimization approach based on Moving Morphable Components (MMC) and the ersatz material model [J]. Struct Multidiscipl Optimiz, 2016, 53: 1243-1260.
[12] 赵兴华，夏之远，菅凤增，等. 适用于BI-AAD患者的寰枢椎侧块关节融合器的研究与设计[J]. 中华神经外科疾病研究杂志，2017，16（6）：485-489.

备注/Memo

备注/Memo:
（2022-06-04收稿，2022-08-15修回）
通讯作者：陈　赞，E-mail：13911712120@163.com
更新日期/Last Update: 2022-12-31