[1]刘长青　陈思畅　关宇光　周　健　翟　峰　栾国明.Sturge-Weber综合征所致难治性癫痫的手术治疗[J].中国临床神经外科杂志,2017,(06):379-381,385.[doi:10.13798/j.issn.1009-153X.2017.06.004]
　LIU Chang-qing,CHEN Si-chang,GUAN Yu-guang,et al.Surgery for refractory epilepsy caused by Sturge-Weber syndrome[J].,2017,(06):379-381,385.[doi:10.13798/j.issn.1009-153X.2017.06.004]
点击复制

Sturge-Weber综合征所致难治性癫痫的手术治疗 ()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年06期
页码:
379-381,385
栏目:
论著
出版日期:
2017-06-25

文章信息/Info

Title:
Surgery for refractory epilepsy caused by Sturge-Weber syndrome
文章编号:
1009-153X（2017）06-0379-03
作者:
刘长青　陈思畅　关宇光　周　健　翟　峰　栾国明
100093 北京，首都医科大学三博脑科医院功能神经外科
通讯作者：栾国明，E-mail：luangm3@163.com
Author(s):
LIU Chang-qing;  CHEN Si-chang;  GUAN Yu-guang;  ZHOU Jian;  ZHAI Feng;  LUAN Guo-ming.
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China
关键词:
Sturge-Weber综合征; 难治性癫痫; 显微手术; 皮层电凝热灼术
Keywords:
Sturge-Weber syndrome;  Intractable epilepsy;  Surgery;  Curative effects
分类号:
R 742.1; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2017.06.004
文献标志码:
A
摘要:
目的 探讨Sturge-Weber综合征所致难治性癫痫的手术方法以及其疗效。方法 回顾性分析2009年4月至2016年4月手术治疗30例Sturge-Weber综合征所致难治性癫痫的临床资料。结果 术后随访3个月至6.1年，按Engel分级评估疗效，Engel Ⅰ级24例，Ⅱ级4例，Ⅳ级2例。术后未见永久性功能障碍。10例术后出现对侧肢体肌力下降1~3级，大部分在3个月后恢复至术前水平；1例出现感觉性失语，术后3个月恢复正常。结论 手术是治疗Sturge-Weber综合征所致难治性癫痫的安全有效的措施。根据病人年龄、神经功能，病变部位及范围不同，采取不同的手术方式，可在控制癫痫发作的同时最大限度保留神经功能。
Abstract:
Objective To investigate the surgical method to treat refractory epilepsy caused by Sturge-Weber syndrome and its curative effect. Method The clinical data of 30 patients with of refractory epilepsy caused by Sturge-Weber syndrome undergoing surgery from April, 2009 to April, 2016 were analyzed retrospectively. Results All the patients were followed up from 0.25~6.1 years. The following up showed that the epilepsy control belonged in Engel grade Ⅰ in 24 cases, grade Ⅱ in 4 and grade Ⅳ in 2. The contralateral limb muscle strength decreased by grade 1 to 3 on discharge from the hospital compared with that before the operation in 10 patients, in whom the muscle strength returned to the normal 3 months after the operation. The speech returned to normal 3 months after the operation in 1 patient with sensory aphasia immediately after the operation. There was no permanent functional impairment after the operation. Conclusions Surgery is a safe and effective method to treat refractory epilepsy caused by Sturge-Weber syndrome. The different surgical fashion chosen according to the patient's age, neurological function and location and range of the lesion is helpful to the control of epileptic seizures and maximal retention of nervous function.

参考文献/References:

[1] Bachur CD, Comi AM. Sturge-weber syndrome [J]. Curr Treat Options Neurol, 2013, 15: 607-617.
[2] Comi AM. Presentation, diagnosis, pathophysiology, and treatment of the neurological features of Sturge-Weber syndrome [J]. Neurologist, 2011, 17: 179-184.
[3] Abdolrahimzadeh S, Scavella V, Battaglia D, et al. Spectral domain optical coherence tomography of choroidal and outer retinal layer thickness in the sturge weber syndrome [J]. Curr Eye Res, 2016, 41(12): 1614-1617
[4] Siri L, Giordano L, Accorsi P, et al. Clinical features of Sturge-Weber syndrome without facial nevus: five novel cases [J]. Eur J Paediatr Neurol, 2013, 17: 91-96.
[5] 张立红，王苏平，彭道勇. 我国Sturge-Weber综合征癫痫 病例临床特点分析[J]. 中国实用医药，2014，9（7）：68-70.
[6] Kossoff EH, Bachur CD, Quain AM, et al. EEG evolution in Sturge-Weber syndrome [J]. Epilepsy Research, 2014, 108: 816-819.
[7] Fogarasi A, Loddenkemper T, Mellado C, et al. Sturge- Weber syndrome: clinical and radiological correlates in 86 patients [J]. Ideggyogy Sz, 2013, 66: 53-57.
[8] George U, Rathore S, Nittala P. MR demonstration of acce- lerated myelination in early sturge Weber syndrome [J]. Neurol India, 2010, 58: 336-337.
[9] Marana PA, Ruiz-Falco RM, Puertas MV, et al. Analysis of Sturge-Weber syndrome: a retrospective study of multiple associated variables [J]. Neurologia, 2016. pii: S0213-4853 (16)00024-4.
[10] 田　宏，常鹏飞，栾国明，等. 选择性多脑叶切除联合致痫 皮层热灼术治疗Sturge-weber综合征1例[J]. 立体定向 和功能性神经外科杂志，2007，20（6）：334-337.
[11] 齐雪岭，周　健，姚　坤，等. 脑面血管瘤病19例临床病 理分析[J]. 中国微侵袭神经外科杂志，2014，19（9）：405- 408.

相似文献/References:

[1]杨朋范　梅　珍　张辉建　裴家生　林　巧　贾延增　钟忠辉.颞顶枕离断术治疗儿童单侧多脑叶难治性癫痫[J].中国临床神经外科杂志,2015,(10):605.[doi:10.13798/j.issn.1009-153X.2015.10.009]
　YANG Peng-fan,MEI Zhen,ZHANG Hui-jian,et al.Disconnective surgery for unilateral posterior quadrantic epilepsy: a series of 17 paediatric patients[J].,2015,(06):605.[doi:10.13798/j.issn.1009-153X.2015.10.009]
[2]徐志明 综述　王桂松 审校.外周神经电刺激治疗难治性癫痫研究现状[J].中国临床神经外科杂志,2015,(05):309.[doi:10.13798/j.issn.1009-153X.2015.05.020]
[3]杜　浩　黄玲玥　向　露　刘　琴　吕丽辉　陈璐璐　徐国政.难治性癫痫致痫灶的术前常用评估方法及有效性分析[J].中国临床神经外科杂志,2017,(04):224.[doi:10.13798/j.issn.1009-153X.2017.04.006]
　DU Hao,HUANG Ling-yue,XIANG Lu,et al.Common methods to evaluate refractory epilepsy preoperatively and their effects on localization of epileptogenic foci[J].,2017,(06):224.[doi:10.13798/j.issn.1009-153X.2017.04.006]
[4]潘军红　顾晶晶　周　健　关宇光　栾国明.丘脑前核电刺激术治疗难治性癫痫的围手术期护理[J].中国临床神经外科杂志,2017,(06):388.[doi:10.13798/j.issn.1009-153X.2017.06.007]
[5]邱　勇　乔　旭　蔡永庆　徐海龙.立体定向海马-杏仁核损毁术治疗难治性癫痫致右动眼神经麻痹1例[J].中国临床神经外科杂志,2018,(08):570.[doi:doi:10.13798/j.issn.1009-153X.2018.08.022]
[6]刘长青　程　前　关宇光　栾国明.机器人引导立体脑电射频毁损治疗下丘脑错构瘤所致癫痫[J].中国临床神经外科杂志,2019,(08):489.[doi:10.13798/j.issn.1009-153X.2019.08.013]
[7]周　刚　丁江伟　董　阳　李　远　王树凯.以额面部葡萄酒色样痣为表现的Sturge-Weber综合征1例[J].中国临床神经外科杂志,2021,26(08):653.[doi:10.13798/j.issn.1009-153X.2021.08.028]
[8]卜金鑫,朱海涛,徐宏浩,等.基于脑磁图的高频振荡在难治性癫痫中的研究进展[J].中国临床神经外科杂志,2024,29(08):491.[doi:10.13798/j.issn.1009-153X.2024.08.011]
　BU Jin-xin,ZHU Hai-tao,XU Hong-hao,et al.Research advances of high-frequency oscillations based on magnetoencephalography in intractable epilepsy[J].,2024,29(06):491.[doi:10.13798/j.issn.1009-153X.2024.08.011]

备注/Memo

备注/Memo:
基金项目：首都医科大学基础临床合作课题（13JL51）；首都临床特色应用研究（Z131107002213169）；首都卫生发展科研专项（2016-4-8011）
更新日期/Last Update: 2017-06-25