[1]高玉松　吕宏迪　扈俊华　罗新民　胡承啸　张松坡　柴　超　雷亚平.fMRI联合WCST对颅脑爆震伤额叶执行功能的评估[J].中国临床神经外科杂志,2017,(12):821-823.[doi:10.13798/j.issn.1009-153X.2017.12.007]
　GAO Yu-song,Lü Hong-di,HU Jun-hua,et al.Evaluation of executive function of frontal lobes in patients with blast craniocerebral injury by resting fMRI combined with WCST[J].,2017,(12):821-823.[doi:10.13798/j.issn.1009-153X.2017.12.007]
点击复制

fMRI联合WCST对颅脑爆震伤额叶执行功能的评估()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年12期
页码:
821-823
栏目:
论著
出版日期:
2017-12-25

文章信息/Info

Title:
Evaluation of executive function of frontal lobes in patients with blast craniocerebral injury by resting fMRI combined with WCST
文章编号:
1009-153X（2017）12-0821-03
作者:
高玉松　吕宏迪　扈俊华　罗新民　胡承啸　张松坡　柴　超　雷亚平
作者单位：450000 河南驻马店，解放军第159医院神经外科（高玉松、扈俊华、罗新民、胡承啸、张松坡、柴　超、雷亚平），院长（吕宏迪） 通讯作者：吕宏迪，E-mail：rancho1213@foxmail.com
Author(s):
GAO Yu-song;  Lü Hong-di;  HU Jun-hua;  LUO Xin-min;  HU Cheng-xiao;  HU Song-po;  CHAI Chao;  LEI Ya-ping;  YAN De-qi.
Department of Neurosurgery, 159th Hospital, PLA, Zhumadian 463000, China
关键词:
颅脑爆震伤; 功能磁共振; 威斯康辛卡片分类测试; 额叶执行功能; 评估
Keywords:
Blast craniocerebral injury;  Wisconsin card sorting test;  Frontal lobe network;  Executive function
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2017.12.007
文献标志码:
A
摘要:
目的 利用静息态功能磁共振成像（fMRI）和威斯康辛卡片分类测试（WCST）评估颅脑爆震伤恢复期的额叶执行功能。方法 以同一次军事训练中受伤4例成年男性颅脑爆震伤为观察组，以6例健康男性成年人为对照；采集fMRI数据构建脑网络并计算其平均额叶度；同时进行WCST测试。结果 受试者头动分析发现，平移不超过2 mm，角度不超过2°，无受试者因头动被剔除。观察组额叶度（4.750±0.646）显著低于对照组（5.550±0.409；P<0.05）；两组WCST测试结果均在正常范围内，但观察组WCST值（4.500±0.577）明显低于对照组（6.167±0.753；P<0.05）。观察组额叶平均度和WCST测试得分具有显著相关性（r=0.821，P<0.05），对照组额叶平均度和WCST测试得分也具有显著相关性（r=0.813，P<0.05）。结论 颅脑爆震伤恢复期额叶网络可能存在潜在的问题，会引起执行力测试在正常范围内的下降。
Abstract:
【Abstract】 Objective To evaluate the executive function of frontal lobes in the patients with blast craniocerebral injury by brain function network constructed with resting functional magnetic resonance imaging (fMRI) and Wisconsin Card Sorting Test (WCST). Methods The resting fMRI was performed 3 months after the injury in 4 patients with blast craniocerebral injury and 6 healthy subjects serving as control in order to construct the brain nets and then the average frontal lobes degrees were calculated. WCST was performed at the same time in all the patients and the subjects. The differences in frontal lobe degree and WCST scores were compared between both the groups. The correlativity of the frontal lobes degree with WCST scores were analyzed by pearson correlation. Result The frontal lobes degree and WCST scores were significantly lower in patients with blast craniocerebral injury than those in the healthy subjects (P<0.05), although the WCST scores were in the normal range. Frontal lobes degree was significantly positively associated with the WCST scores in both the groups (P<0.05). Conclusion It is suggested that the frontal lobe networks 3 months after the injury in the patients with blast craniocerebral injury may have potential disturbance, which may lead to a decrease in executive ability shown by WCST in the normal range.

参考文献/References:

[1] Thompson JM, Scott KC, Dubinsky L. Battlefield brain: unexplained symptoms and blast-related mild traumatic brain injury [J]. Can Fam Physician, 2008, 54(11): 1549- 1551. [2] Kim JS, Kim OL, Seo WS, et al. Memory dysfunctions after mild and moderate traumatic brain injury: comparison between patients with and without frontal lobe injury [J]. J Korean Neurosurg Soc, 2009, 46(5): 459-467. [3] Levin HS, Robertson CS. Mild traumatic brain injury in translation [J]. J Neurotrauma, 2013, 30(8): 610-617. [4] Hill EL. Evaluating the theory of executive dysfunction in autism [J]. Develop Rev, 2004, 24(2): 189-233. [6] Godefroy O, Cabaret M, Petit-Chenal V, et al. Control functions of the frontal lobes: modularity of the central- supervisory system [J]? Cortex, 1999, 35(1): 1-20. [7] 余　果，鲍伟民，毛　颖，等. 轻度左侧额、颞叶挫伤患者 执行功能的评价[J]. 复旦学报（医学版），2010，37（4）： 447-449.

相似文献/References:

[1]皇甫罗锴　程　岗　贾　博　王淑为　郭胜利　任　斌　李彦腾　张剑宁.多舱室爆炸致比格犬血清皮质醇、生长激素、泌乳素的变化及其与伤情的关系[J].中国临床神经外科杂志,2020,(02):94.[doi:10.13798/j.issn.1009-153X.2020.02.011]
　HUANGFU Luo-kai,CHENG Gang,JIA Bo,et al.Effects of multi-cabins explosion on serum levels of cortisol, GH and PRL and their relationship with injury severity in Beagle dogs[J].,2020,(12):94.[doi:10.13798/j.issn.1009-153X.2020.02.011]
[2]高玉松,吕宏迪,扈俊华,等.颅脑爆震伤病人恢复期脑网络的研究[J].中国临床神经外科杂志,2017,(07):477.[doi:10.13798/j.issn.1009-153X.2017.07.010]
　GAO Yu-song,Lü Hong-di,HU Jun-hua,et al.Change in brain network in patients with craniocerebral blast injury: a study based on resting functional magnetic resonance imaging[J].,2017,(12):477.[doi:10.13798/j.issn.1009-153X.2017.07.010]

备注/Memo

备注/Memo:
基金项目：军队后勤科研计划项目（CJN15J089）
更新日期/Last Update: 2017-12-27