[1]颜永强　洪　伟.单纯颅脑损伤病人凝血功能异常的相关因素[J].中国临床神经外科杂志,2018,(03):168-169172.[doi:10.13798/j.issn.1009-153X.2018.03.009]
　YAN Yong-qiang,HONG Wei..Analysis of factors related to coagulopathy in patients with traumatic brain injury[J].,2018,(03):168-169172.[doi:10.13798/j.issn.1009-153X.2018.03.009]
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单纯颅脑损伤病人凝血功能异常的相关因素()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年03期
页码:
168-169172
栏目:
论著
出版日期:
2018-04-01

文章信息/Info

Title:
Analysis of factors related to coagulopathy in patients with traumatic brain injury
文章编号:
1009-153X（2018）03-0168-02
作者:
颜永强　洪　伟
作者单位：611130 四川，成都市温江区人民医院神经外科（颜永强、洪　伟）
Author(s):
YAN Yong-qiang;  HONG Wei.
Department of Neurosurgery, Wenjiang District People’s Hospital, Chengdu City, Chengdu 611130, China
关键词:
颅脑损伤; 凝血病; 影响因素; 纤维蛋白原
Keywords:
Coagulopathy;  Traumatic brain injury;  Related factors;  Fibrinogen
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2018.03.009
文献标志码:
A
摘要:
目的 探讨单纯颅脑损伤（TBI）病人凝血功能异常的影响因素。方法 回顾性分析2012年1月至2015年12月收治的136例单纯TBI的临床资料，采用多因素Logistic回归分析检验并发凝血病的影响因素。结果 136例中，并发凝血病51例，其中纤维蛋白原异常率最高（29.4%），其次是国际标准化比值（19.1%）。GCS评分≤8分、血糖水平≥20.1 mmol/L、中线移位、硬膜下血肿、脑室内出血是单纯TBI发生凝血病的独立危险因素（P<0.05）。结论 TBI入院后建议密切监测凝血功能、血糖，及时完善CT、MRI等检查，对于Fib和INR异常、血糖升高、中线移位、硬膜下血肿、脑室内出血的TBI病人，应注意防治TBI相关性凝血病。
Abstract:
Objective To explore the factors related to coagulopathy in the patients with traumatic brain injury (TBI). Methods Of 136 patients with TBI treated in our hospital from January, 2012 to December, 2015, 51 suffered from coagulopathy (coagulopathy group) and 85 not (non-coagulopathy group). Multiple factors logistic regression analysis was performed to screen out the independent factors related to coagulopathy. Results The monofactorial analysis showed that patients with abnormal levels of blood fibrinogen (Fib) accounted for 29.4% of all the patients with TBI and patients with abnormal international normalized ratio (INR) accounted for 19.1% of all the patients with TBI. There were significant differences in GCS scores, blood glucose levels, midline shift on CT, skull fracture, acute subdural hematoma and intraventricular bleeding between two groups (P<0.05). the multiple factors logistic regression analysis showed that GCS scores ≤8 point, blood glucose level ≥20.1 mmol/L, midline shift on CT image, acute subdural hematoma and intraventricular bleeding were the independent risk factors of coagulopathy (P<0.05). Conclusions The main forms of coagulopathy in the patients with TBI were abnormal FIB and INR. The independent risk factors of coagulopathy include GCS scores ≤8 point, blood glucose level ≥20.1 mmol/L, midline shift on CT image, acute subdural hematoma and intraventricular bleeding in the patients with TBI.

参考文献/References:

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更新日期/Last Update: 2018-05-05