[1]王栎雯　栗彦飞　陈　芳　刘　畅　谢丹尼　莫发荣.Cdc25C在人脑膜瘤组织中的表达及其临床意义[J].中国临床神经外科杂志,2019,(05):292-294.[doi:10.13798/j.issn.1009-153X.2019.05.011]
　WANG Li-wen,LI Yan-fei,CHEN Fang,et al.Expression and clinical meanings of Cdc25C in human meningioma tissues[J].,2019,(05):292-294.[doi:10.13798/j.issn.1009-153X.2019.05.011]
点击复制

Cdc25C在人脑膜瘤组织中的表达及其临床意义()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年05期
页码:
292-294
栏目:
论著
出版日期:
2019-05-27

文章信息/Info

Title:
Expression and clinical meanings of Cdc25C in human meningioma tissues
文章编号:
1009-153X（2019）05-0292-03
作者:
王栎雯　栗彦飞　陈　芳　刘　畅　谢丹尼　莫发荣
530021 南宁，广西医科大学组织学与胚胎学教研室（王栎雯、栗彦飞、陈　芳、谢丹尼、莫发荣）；530021 南宁，广西医科大学第一附属医院神经外科（刘畅）
Author(s):
WANG Li-wen1;  LI Yan-fei1;  CHEN Fang1;  LIU Chang2;  XIE Dan-ni1;  MO Fa-rong1
1. Department of Histology and Embryology, Guangxi Medical University, Nanning 530021, China; 2. Department of Neurosurgery, The First Affliated Hospital of Guangxi Medical University, Nanning 530021, China
关键词:
脑膜瘤; 细胞分裂周期蛋白25同源蛋白C ; 基因表达
Keywords:
Meningiomas;  Cdc25C;  Expression;  Clinical meanings
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2019.05.011
文献标志码:
A
摘要:
目的 探讨人脑膜瘤组织细胞分裂周期蛋白25同源蛋白C（Cdc25C）的表达及其临床意义。方法 选取手术切除并经病理证实的36例人脑膜瘤组织和6例人正常脑组织，提取相应组织的总RNA后，分别以RT-PCR和qPCR技术检测Cdc25C cDNA和mRNA，并结合病人的临床资料进行统计分析。结果 Cdc25C在人脑膜瘤组织中的阳性率为66.67%，明显高于其在正常人脑组织中的阳性率16.67%（P<0.05）；Cdc25C mRNA在人脑膜瘤组织中的表达量约为其在人正常脑组织中的3.3倍（P<0.05）。Cdc25C在脑膜瘤组织中的阳性率和阳性表达水平均与病人的年龄、性别、肿瘤大小、病理类型及WHO病理分级等临床病理特征无关（P>0.05）。结论 Cdc25C过表达可能与脑膜瘤的发生相关。
Abstract:
ObjectiveTostudytherelationshipbetweenCdc25Cinmeningiomatissuesandpathogenesisofmeningiomas.MethodsThelevelsofCdc25CDNAandmRNAexpressionsweredetectedbyRT-PCRandqPCRrespectivelyinthe36casesofhumanmeningiomatissuesand6casesofnormalhumanbraintissues.ResultsThepositiverateofCdc25C(66.67%,24/36)wassignificantlyhigherinthemeningiomastissuesthanthatinthenormalbraintissues(P<0.05).ThelevelofCdc25CmRNAexpressionwassignificantlyhigherinthemeningiomatissuesthanthatinthenormalhumanbraintissues(P<0.05).ThepositiverateandexpressionlevelofCdc25Cinthemeningiomatissueswerenotsignificantlyrelatedwiththepatient'sageandgender,andtumorsize,pathologictypeandtheWHOpathologicalgrade(P>0.05).ConclusionItissuggestedthattheoverexpressionofCdc25Cmaybeassociatedwiththepathologenesisofmeningioma.

参考文献/References:


[1] Wang X, Zhao H, Xu Q, et al. HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma [J]. Nucleic Acids Res, 2006, 34(Database issue): D607-D612.
[2] Kawabe T. G2 checkpoint abrogators as anticancer drugs [J]. Mol Cancer Ther, 2004, 3(4): 513-519.
[3] Bagheri-Yarmand R, Nanos-Webb A, Biernacka A, et al. Cyclin E deregulation impairs mitotic progression through premature activation of Cdc25C [J]. Cancer Res, 2010, 70(12): 5085-5095.
[4] Wang Z, Trope CG, Fl?renes VA, et al. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malig-nant features and aggressive cancer phenotypes [J]. BMC Cancer, 2010, 10: 233.
[5] García-Morales P, Carrasco-García E, Ruiz-Rico P, et al. Inhibition of Hsp90 function by ansamycins causes down-regulation of cdc2 and cdc25c and G(2)/M arrest in gliob-lastoma cell lines [J]. Oncogene, 2007, 26(51): 7185-7193.
[6] Baia GS, Caballero OL, Ho JS, et al. NY-ESO-1 expression in meningioma suggests a rationale for new immunothera-peutic approaches [J]. Cancer Immunol Res, 2013, 1(5): 296-302.
[7] Sioka C, Kyritsis AP. Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas [J]. J Neurooncol,2009, 92(1): 1-6.
[8] 梁马克，李仁锋，夏晓博，等. CDC25C蛋白和CLDN6蛋白在肝细胞癌中的表达及临床意义[J]. 河南医学研究，2013， 22（6）：807-811.
[9] 张　强，张仲富，丁　宇，等. CDC25C基因在肾透明细胞癌中的表达及临床意义[J]. 安徽医科大学学报，2012，47（11）：1336-1339.
[10] 张琪惠，李春梅，黄天明，等. CDC25C抗体在肝病病人中的血清学检测[J]. 世界华人消化杂志，2015， 23（36）：5848-5853.
[11] Lindqvist A, van Zon W, Karlsson Rosenthal C, et al. Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression [J]. PLoS Biol, 2007, 5（5）: e123.
[12] Ozen M, Ittmann M. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer [J]. Clin Cancer Res, 2005, 11(13): 4701-4706.

相似文献/References:

[1]李春坡　郑　军　李海元　边　涛　韩安国.侧脑室三角区小型脑膜瘤的显微外科治疗[J].中国临床神经外科杂志,2015,(11):694.[doi:10.13798/j.issn.1009-153X.2015.11.018]
[2]王林风　郑华山　操　廉.中央沟区矢状窦旁脑膜瘤的显微手术治疗（附25例报告）[J].中国临床神经外科杂志,2016,(07):431.[doi:10.13798/j.issn.1009-153X.2016.07.014]
[3]邓学云　刘　毅　范润金　刘丽华　夏祥国.E-cadherin与脑膜瘤分级及瘤周水肿的关系[J].中国临床神经外科杂志,2016,(04):213.[doi:10.13798/j.issn.1009-153X.2016.04.007]
　DENG Xue-yun,LIU Yi,FAN Run-jin,et al.Relationship of E-cadherin with the pathological grade of meningioma and peritumoral brain edema in patients with meningioma[J].,2016,(05):213.[doi:10.13798/j.issn.1009-153X.2016.04.007]
[4]马　磊　张海红　郭　康　孙树凯　张　亮　贾　栋.神经导航辅助下手术治疗侧脑室脑膜瘤1例[J].中国临床神经外科杂志,2016,(04):255.[doi:10.13798/j.issn.1009-153X.2016.04.023]
[5]王　一　崔焕喜　林令超　孙思辉　李绍山　周庆九　刘　波　柳　琛.侧脑室三角区脑膜瘤的显微手术治疗[J].中国临床神经外科杂志,2016,(03):161.[doi:10.13798/j.issn.1009-153X.2016.03.010]
　WANG Yi,CUI Huan-xi,LIN Ling-chao,et al.Microsurgery for meningiomas in the trigones of lateral ventricles (report of 47 cases)[J].,2016,(05):161.[doi:10.13798/j.issn.1009-153X.2016.03.010]
[6]王　鹏 综述　王　勇 审校.岩斜区脑膜瘤的手术入路[J].中国临床神经外科杂志,2016,(02):120.[doi:10.13798/j.issn.1009-153X.2016.02.024]
[7]漆松涛　刘　忆.关于WHO2007年版脑膜瘤病理分类一些问题的商榷[J].中国临床神经外科杂志,2016,(02):125.[doi:10.13798/j.issn.1009-153X.2016.02.026]
[8]李登辉　程　荆　李志强.镰旁脑膜瘤术后并发格林巴利综合征1例[J].中国临床神经外科杂志,2016,(02):72.[doi:10.13798/j.issn.1009-153X.2016.02.003]
[9]肖宗宇　陈晓娟　裴　杰　贺瑛福　许常林　马进海.超声吸引器在脑膜瘤手术切除中的应用[J].中国临床神经外科杂志,2015,(10):626.[doi:10.13798/j.issn.1009-153X.2015.10.016]
[10]杨　俊　吴雪松　莫鸿忠　潘荣南　赖　杰.双源CT三维血管成像技术在脑膜瘤术前评估中的应用[J].中国临床神经外科杂志,2015,(06):347.[doi:10.13798/j.issn.1009-153X.2015.06.009]
　YANG Jun,WU Xue-song,MO Hong-zhong,et al.Application of three-dimensional dual-source CT angiography to preoperative assessment of meningiomas[J].,2015,(05):347.[doi:10.13798/j.issn.1009-153X.2015.06.009]

备注/Memo

备注/Memo:

通讯作者：谢丹尼，E-mail：gxxiedanni@163.com 莫发荣，E-mail：farongmo@126.com
更新日期/Last Update: 2019-05-27