[1]黄涛何东杰杨晨田启龙屈延王举磊.手术联合放化疗治疗儿童髓母细胞瘤的疗效分析[J].中国临床神经外科杂志,2022,27(02):65-67.[doi:10.13798/j.issn.1009-153X.2022.02.001]
　HUANG Tao,HE Dong-jie,YANG Chen,et al.Clinical efficacy of surgical treatment combined with radiotherapy and chemotherapy for pediatric patients with medulloblastoma[J].,2022,27(02):65-67.[doi:10.13798/j.issn.1009-153X.2022.02.001]
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手术联合放化疗治疗儿童髓母细胞瘤的疗效分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年02期
页码:
65-67
栏目:
论著
出版日期:
2022-02-25

文章信息/Info

Title:
Clinical efficacy of surgical treatment combined with radiotherapy and chemotherapy for pediatric patients with medulloblastoma
文章编号:
1009-153X（2022）02-0065-03
作者:
黄涛何东杰杨晨田启龙屈延王举磊
710038 西安，空军军医大学唐都医院神经外科（黄涛、杨晨、田启龙、屈延、王举磊），放疗科（何东杰）
Author(s):
HUANG Tao1;  HE Dong-jie2;  YANG Chen1;  TIAN Qi-long1;  QU Yan1;  WANG Ju-lei1.
1. Department of Neurosurgery, Tangdu Hospital, Air Force Military Medical University, Xi’an 710038, China; 2. Department of Radiotherapy, Tangdu Hospital, Air Force Military Medical University, Xi’an 710038, China
关键词:
髓母细胞瘤; 儿童; 手术; 放疗; 化疗; 预后
Keywords:
Medulloblastoma;  Children;  Surgery;  Radiotherapy;  Chemotherapy;  Prognosis
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2022.02.001
文献标志码:
A
摘要:
目的 探讨手术联合放化疗治疗儿童髓母细胞瘤（MB）的疗效。方法回顾性分析 2017年 1月至 2020年 7月收治的 32例儿童 MB的临床资料。均采用枕下后正中入路手术切除肿瘤，术后行放化疗。结果肿瘤完全或近完全切除 26例，次全切除 6例。术后发生小脑缄默症 7例，硬膜外血肿 1例，后组颅神经受损 5例，皮下积液 3例。32例随访止 2020年 12月，随访时间 9~38个月，平均 23.9个月，次全切除 6例出现进展，其中脊髓转移 3例，死亡 5例；存活 27例中，26例正常生活，1例因肿瘤进展需要照顾。结论对于儿童 MB，手术联合术后足疗程、足量放化疗，延缓肿瘤复发，提高生存率。
Abstract:
Objective To investigate the clinical efficacy of surgical treatment combined with radiotherapy and chemotherapyforthe pediatric patients with medulloblastoma. Methods The clinical data of 32 children with medulloblastoma who received microsurgery combined with radiotherapy and chemotherapy from January 2017 to July 2020 were retrospectively analyzed. Results Total resection of tumors were achieved in 26 children and subtotal in 6. Cerebellar mutism occurred in 7 children, posterior cranialnerve damage in 5, subcutaneous effusion in 3 and epidural hematoma in 1 after the operation. The follow-up (range, 9~38 months;average, 23.9 months) showed progression in 6 children with subtotal resection, including 3 spinal cord metastasis and 5 death. Of 27survival children, 26 lived normally, and 1 required care due to tumor progression. Conclusions For children with MB, surgerycombined with a full course and adequate radiotherapy and chemotherapy can reduce tumor recurrence and improve the survival rate.

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备注/Memo

备注/Memo:
通讯作者：王举磊，E-mail：wangjulei@163.com
更新日期/Last Update: 1900-01-01