[1]马　炜　张　华　李焕发　王　超　孟　强　刘　备　武　昊.伴有丛集发作的儿童癫痫患者的手术治疗[J].中国临床神经外科杂志,2015,(01):8-10.[doi:10.13798/j.issn.1009-153X.2015.01.003]
　MA Wei,ZHANG Hua,LI Huan-fa,et al.Surgery for children with epilepsy and seizure clustering (report of 33 cases)[J].,2015,(01):8-10.[doi:10.13798/j.issn.1009-153X.2015.01.003]
点击复制

伴有丛集发作的儿童癫痫患者的手术治疗()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年01期
页码:
8-10
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Surgery for children with epilepsy and seizure clustering (report of 33 cases)
文章编号:
1009-153X（2015）01-0008-03
作者:
马　炜　张　华　李焕发　王　超　孟　强　刘　备　武　昊
710038 西安，第四军医大学唐都医院神经外科
通讯作者：张　华，E-mail：zhanghua@fmmu.edu.cn
Author(s):
MA Wei;  ZHANG Hua;  LI Huan-fa;  WANG Chao;  MENG Qiang;  LIU Bei;  WU Hao.
Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, China
关键词:
癫痫; 丛集发作; 手术治疗; 儿童
Keywords:
Epilepsy;  Seizure clustering;  Surgical treatment;  Children
分类号:
R 742.1; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2015.01.003
文献标志码:
A
摘要:
目的 探讨伴有丛集发作的儿童癫痫患者的手术评估及疗效。方法 回顾性分析33例伴有丛集发作的儿童癫痫患者的临床资料，其中缓解性手术治疗8例，切除性手术治疗25例。结果 术后随访8~42个月，疗效按Engel分级：缓解性手术治疗患者Ⅱ级2例，Ⅲ级4例，Ⅳ级2例；切除性手术治疗患者Ⅰ级16例，Ⅱ级4例，Ⅲ级3例，Ⅳ级2例。无手术相关永久性并发症发生。结论 对于伴有丛集发作的儿童癫痫患者，应尽早进行综合的术前评估并采取相应的手术治疗以获得更好的控制疗效，从而改善患者预后。
Abstract:
Objective To explore the preoperative assessment of children with epilepsy and seizure clustering and the curative effect of surgery on them. Method The clinical data of 33 children with epilepsy and seizure clustering were analyzed retrospectively, including the patient’s preoperative assessment and following up data and so on. Results The epilepsy children with seizure clustering accounted for 24.3% (33/136) of the children with epilepsy who underwent the surgery from January, 2011 to December, 2013. Of 33 epilepsy children with seizure clustering, 8 underwent palliative surgery (callosotomy) and 25 underwent resection surgery (hemispherectomy, focal resection, part callosotomy and so on). All the children were followed up from 8 to 42 months. According to Engel class, control effect on the epileptic seizures reached Engel class Ⅱ in 2, class Ⅲ in 4 and class Ⅳ in 2 in 8 children undergoing the palliative surgery and reached Engel class Ⅰ in 16, class Ⅱ in 4, class Ⅲ in 3 and class Ⅳ in 2 in 25 children undergoing the resection surgery. There was no permanent surgery-related complications occurred in all the children. Conclusions Seizure clustering seriously affects the quality of life in patients with epilepsy. The earlier comprehensive preoperation assessment and surgical management should be recommended to achieve satisfactory control of seizure and good prognoses in the epilepsy children with seizure clustering.

参考文献/References:

[1] Haut SR, Shinnar S, Moshe SL. Seizure clustering: risks and outcomes [J]. Epilepsia, 2005, 46: 146-149.
[2] Haut SR, Lipton RB, LeValley AJ, et al. Identifying seizure clusters in patients with epilepsy [J]. Neurology, 2005, 65: 1313-1315.
[3] Rose AB, McCabe PH, Gilliam FG, et al. Occurrence of seizure clusters and status epilepticus during inpatient video-EEG monitoring [J]. Neurology, 2003, 60: 975-978.
[4] Haut SR, Swick C, Freeman K, et al. Seizure clustering during epilepsy monitoring [J]. Epilepsia, 2002, 43: 711-715.
[5] Cossu M, Fuschillo D, Bramerio M, et al. Epilepsy surgery of focal cortical dysplasia-associated tumors [J]. Epilepsia, 2013, 54(Suppl 9): 115-122.
[6] Aldenkamp AP, Bodde N. Behaviour, cognition and epilepsy[J]. Acta Neurol Scand Suppl, 2005, 182: 19-25.
[7] Galanopoulou AS, Moshe SL. The epileptic hypothesis: deve-lopmentally related arguments based on animal models [J]. Epilepsia, 2009, 50 Suppl 7: 37-42.
[8] Sillanpaa M, Schmidt D. Seizure clustering during drug treatment affects seizure outcome and mortality of child-hood-onset epilepsy [J]. Brain, 2008, 131: 938-944.
[9] Talairach J, Bancaud J, Bonis A, et al. Surgical therapy for frontal epilepsies [J]. Adv Neurol, 1992, 57: 707-732.
[10] Rahimi SY, Park YD, Witcher MR, et al. Corpus callosotomyfor treatment of pediatric epilepsy in the modern era [J]. Pe-diatr Neurosurg, 2007, 43: 202-208.
[11] Karakis I, Montouris GD, Piperidou C, et al. The effect of epilepsy surgery on caregiver quality of life [J]. Epilepsy Res, 2013, 107: 181-189.

相似文献/References:

[1]云德波　杨宇焦　张　逵　范润金　张　渊　杜贻庆.瘤周谷氨酸、天门冬氨酸水平与胶质瘤继发性 癫痫的相关性[J].中国临床神经外科杂志,2016,(06):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
　YUN De-bo,YANG Yu-Jiao,ZHANG Kui,et al.Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas[J].,2016,(01):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
[2]周长帅　任志伟 综述　遇　涛　李勇杰 审校.岛叶癫痫症状学研究进展周长[J].中国临床神经外科杂志,2016,(04):249.[doi:10.13798/j.issn.1009-153X.2016.04.021]
[3]田春雷　王晓丹 综述　王雄伟 审校.局灶性皮层发育不良与mTOR信号通路[J].中国临床神经外科杂志,2016,(02):122.[doi:10.13798/j.issn.1009-153X.2016.02.025]
[4]黄　河　杜　浩　吕丽辉　宋　健　黄　成　何远志　孙荣辉　丁慧超　黄玲玥　徐国政　马廉亭.影像融合及颅内电极三维重建在癫痫术前计划中的应用[J].中国临床神经外科杂志,2015,(12):705.[doi:10.13798/j.issn.1009-153X.2015.12.001]
　HUANG He,DU Hao,Lü Li-hui,et al.Value of MRI and CT images co-registration and three-dimensional visualization of intracranial electrodes to presurgical planning for epilepsy surgery[J].,2015,(01):705.[doi:10.13798/j.issn.1009-153X.2015.12.001]
[5]孙　拯　谢延风　石全红　但　炜　詹　彦　陆　波　孙晓川.以癫痫起病的幕上脑海绵状血管瘤的治疗[J].中国临床神经外科杂志,2015,(12):709.[doi:10.13798/j.issn.1009-153X.2015.12.002]
　SUN Zheng,XIE Yan-feng,SHI Quan-hong,et al.Treatment of supratentorial cerebral cavernous angioma associated with epilepsy as first symptom[J].,2015,(01):709.[doi:10.13798/j.issn.1009-153X.2015.12.002]
[6]王林林　李宗正.癫痫致呼吸停止1例[J].中国临床神经外科杂志,2015,(06):359.[doi:10.13798/j.issn.1009-153X.2015.06.014]
[7]孙荣辉　徐国政　杜　浩　宋　健　黄　河　赵曰圆　马廉亭.MRI与DSA影像融合联合电生理监测对脑动静脉畸形伴癫痫手术的价值[J].中国临床神经外科杂志,2015,(07):403.[doi:10.13798/j.issn.1009-153X.2015.07.007]
　SUN Rong-hui,XU Guo-zheng,DU Hao,et al.Value of MRI and 3D-DSA images fusion combined with intraoperative neuro-electrophysiological technique to surgery for intracranial arteriovenous malformation associated with epilepsy[J].,2015,(01):403.[doi:10.13798/j.issn.1009-153X.2015.07.007]
[8]刘庚勋 综述　李正贤 审校.痫相关低级别中枢神经系统肿瘤的病理学诊断[J].中国临床神经外科杂志,2015,(03):183.[doi:10.13798/j.issn.1009-153X.2015.03.021]
[9]张所军　王　艳　欧一博　陈　旭 舒　凯　牛洪泉　雷　霆.以癫痫起病的颞叶海绵状血管瘤的手术治疗[J].中国临床神经外科杂志,2016,(08):449.[doi:10.13798/j.issn.1009-153X.2016.08.001]
　ZHANG Suo-jun,WANG Yan,OU Yi-bo,et al.Microsurgery for cavernous angiomas initially presenting with seizures[J].,2016,(01):449.[doi:10.13798/j.issn.1009-153X.2016.08.001]
[10]王逸鹤　赵国光　单永治　樊晓彤　安　阳.皮层脑电图监测在伴有癫痫的颞叶海绵状血管瘤手术中的作用[J].中国临床神经外科杂志,2016,(08):463.[doi:10.13798/j.issn.1009-153X.2016.08.006]
　WANG Yi-he,ZHAO Guo-guang,SHAN Yong-zhi,et al.Electrocorticography-guided resection of temporal cavernous malformations associated with epilepsy[J].,2016,(01):463.[doi:10.13798/j.issn.1009-153X.2016.08.006]

备注/Memo

备注/Memo:
基金项目：国家自然科学基金资助项目（编号：81271433）
更新日期/Last Update: 2015-01-30