[1]云德波　杨宇焦　张　逵　范润金　张　渊　杜贻庆.瘤周谷氨酸、天门冬氨酸水平与胶质瘤继发性 癫痫的相关性[J].中国临床神经外科杂志,2016,(06):331-332.[doi:10.13798/j.issn.1009-153X.2016.06.004]
　YUN De-bo,YANG Yu-Jiao,ZHANG Kui,et al.Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas[J].,2016,(06):331-332.[doi:10.13798/j.issn.1009-153X.2016.06.004]
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瘤周谷氨酸、天门冬氨酸水平与胶质瘤继发性 癫痫的相关性()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年06期
页码:
331-332
栏目:
论著
出版日期:
2016-06-25

文章信息/Info

Title:
Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas
文章编号:
1009-153X（2016）06-0331-02
作者:
云德波　杨宇焦　张　逵　范润金　张　渊　杜贻庆
637000 四川，南充市中心医院神经外科（云德波、张　逵、范润金、张　渊）；637000 四川，川北医学院附属医院麻醉科（杨宇焦）；541000 广西桂林，桂林医学院医学院附属医院神经外科（杜贻庆）
Author(s):
YUN De-bo1;  YANG Yu-Jiao2;  ZHANG Kui1;  FAN Run-jin1;  ZHANG Yuan1;  DU Yi-qing3.
1. Department of Neurosurgery, Nanchong City Central Hospital, Nanchong 637000, China; 2. Department of Anesthesiology, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China; 3. Department of Neurosurgery, Affiliated Hospital, Guilin Medical College, Guilin 541000, China
关键词:
胶质瘤; 癫痫; 谷氨酸; 天门冬氨酸
Keywords:
Glioma;  Secondary epilepsy;  Glutamate;  Aspartate;  Peritumorous tissues;  Relationship
分类号:
R 739.41; R 742.1
DOI:
10.13798/j.issn.1009-153X.2016.06.004
文献标志码:
A
摘要:
目的 探讨瘤周谷氨酸、天门冬氨酸浓度与胶质瘤继发性癫痫的相关性。方法 收集2012年5月2015年1月手术治疗的胶质瘤瘤周组织标本47例，其中继发癫痫28例（癫痫组），未继发癫痫19例（无癫痫组）。利用全自动L-8900高速氨基酸分析仪检测标本的谷氨酸、天门冬氨酸水平。结果 癫痫组瘤周谷氨酸、天冬氨酸含量分别为（117.54±8.63）mg/100 g、（70.79±4.70）mg/100 g，均明显高于无癫痫组[分别为（91.76±7.36）mg/100 g、（59.70±5.50）mg/100 g；P <0.05]。瘤周谷氨酸、天冬氨酸含量与癫痫均具有显著相关性，相关系数分别为0.96、0.95（P <0.05）。结论 瘤周组织谷氨酸、天门冬氨酸浓度增加可能与胶质瘤继发性癫痫有关。
Abstract:
Objective To study the relationship of the levels of glutamate and aspartate in the peritumorous tissues with seizures in order to provide the basis for understanding of pathophysiological mechanism of the epilepsy secondary to glioma. Methods Of 47 specimens of gliomas, 28 were derived from the gliomas patients with secondary epilepsy and 19 from the gliomas patients without secondary epilepsy. The levels of glutamate and aspartate in the peritumorous tissues were determined by automatic high-speed L-8900 amino acid analyzer. Results The levels of glutamate and aspartate in the peritumorous tissues were significantly higher in the gliomas patients with secondary epilepsy than those in the gliomas patients without secondary epilepsy (P <0.05). The seizure with the levels of glutamate and aspartate in the peritumorous tissues is positively correlated in the patients with gliomas. Conclusion It is suggested that the higher concentrations of glutamate and aspartate in the peritumorous tissues may be one of the pathophysiological mechanisms of seizures in the gliomas patients with secondary epilepsy.

参考文献/References:

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更新日期/Last Update: 2016-06-20