[1]鲍彤,李静,孔为园,等.重型颅脑损伤病人血清NF-L和TIMP-2水平变化及临床意义[J].中国临床神经外科杂志,2023,28(05):307-310.[doi:10.13798/j.issn.1009-153X.2023.05.005]
　BAO Tong,LI Jing,KONG Wei-yuan,et al.Changes of serum levels of NF-L and TIMP-2 in patients with severe traumatic brain injury and their clinical significance[J].,2023,28(05):307-310.[doi:10.13798/j.issn.1009-153X.2023.05.005]
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重型颅脑损伤病人血清NF-L和TIMP-2水平变化及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
28
期数:
2023年05期
页码:
307-310
栏目:
论著
出版日期:
2023-05-31

文章信息/Info

Title:
Changes of serum levels of NF-L and TIMP-2 in patients with severe traumatic brain injury and their clinical significance
文章编号:
1009-153X（2023）05-0307-04
作者:
鲍彤; 李静; 孔为园; 杨磊; 王鹏飞
050000，石家庄市人民医院神经外三科（鲍彤、李静、孔为园、杨磊）；050000石家庄，河北省人民医院神经外科（王鹏飞）
Author(s):
BAO Tong1;  LI Jing1;  KONG Wei-yuan1;  YANG Lei1;  WANG Peng-fei2
1. Department of Neurosurgery, Shijiazhuang People's Hospital, Shijiazhuang 050000, China; 2. Department of Neurosurgery, Hebei People's Hospital, Shijiazhuang 050000, China
关键词:
重型颅脑损伤; 神经丝蛋白轻链多肽（NF-L）; 组织基质金属蛋白酶抑制因子-2（TIMP-2）; 血清; 预后
Keywords:
severe traumatic injury;  Serum;  Neurofilament light chain polypeptide (NF-L);  Tissue matrix metalloproteinase-2 (TIMP-2);  Prognosis
分类号:
A
DOI:
10.13798/j.issn.1009-153X.2023.05.005
文献标志码:
R651.1+5
摘要:
目的 探讨重型颅脑损伤（TBI）病人血清神经丝蛋白轻链多肽（NF-L）、组织基质金属蛋白酶抑制因子-2（TIMP-2）的水平变化及临床意义。方法 2019年8月~2021年8月前瞻性收集重型TBI共122例，采用酶联免疫吸附试验检查入院血清NF-1和TIMP-2水平；伤后6个月，应用GOS评分评估预后，其中4~5分为预后良好，1~3分为预后不良。结果 伤后6个月，预后良好72例，预后不良50例。预后不良组血清NF-L以及TIMP-2水平明显高于预后良好组（P<0.05）。入院血清NF-L水平（r=-0.585）、TIMP-2水平（r=-0.542）与入院GCS评分呈明显负相关（P<0.05）。多因素Cox回归分析显示，血清NF-L、TIMP-2水平增高是重型TBI伤后6个月预后不良的独立危险因素（P<0.05）。ROC曲线分析显示血清NF-L1≥54.60 pg/ml联合血清TIMP-2≥42.59 ng/ml预测重型TBI伤后6个月预后不良的曲线下面积为0.854（95% CI 0.789~0.919），灵敏度为82.0%，特异度为70.8。结论 重型TBI病人血清NF-L、TIMP-2水平明显增高，是伤后6个月预后不良的危险因素；两者联合应用对病人预后具有较高的预测价值。
Abstract:
Objective To investigate the changes of serum levels of neurofilament light chain polypeptide (NF-L) and tissue matrix metalloproteinase-2 (TIMP-2) in patients with severe traumatic injury (TBI) and their clinical significance. Methods A total of 122 patients with severe TBI were prospectively collected from August 2019 to August 2021. The serum levels of NF-1 and TIMP-2 were detected by enzyme-related immunosorbent assay on admission. The GOS score was used to evaluate the prognosis 6 months after injury, with a score of 4~5 as good prognosis and a score of 1~3 as poor prognosis. Results Six months after injury, 72 patients had good prognoses and 50 patients had poor prognoses. The serum levels of NF-L and TIMP-2 in patients with poor prognoses were significantly higher than those in patients with good prognoses (P<0.05). The serum levels of NF-L (r=-0.585) and TIMP-2 (r=-0.542) were negatively significantly correlated with GCS scores on admission (P<0.05). Multivariate Cox regression analysis showed that increase in serum levels of NF-L and TIMP-2 were independent risk factors for poor prognosis of patients with severe TBI 6 months after injury (P<0.05). ROC curve analysis showed that the area under the curve of serum NF-L 1≥54.60 pg/ml and serum TIMP-2≥42.59 ng/ml for predicting poor prognoses of patients with severe TBI 6 months after injury was 0.854 (95%CI 0.789~0.919), with a sensitivity of 82.0% and a specificity of 70.8. Conclusions Serum levels of NF-L and TIMP-2 in severe TBI patients are significantly increased, which are risk factors for poor prognoses 6 months after injury. Combination of serum levels of NF-L and TIMP-2 has high predictive value for prognosis of patients with severe TBI 6 moths after injury.

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备注/Memo

备注/Memo:
（2022-05-13收稿，2023-03-27修回）
基金项目：河北省医学科学研究课题计划项目（20200003）；石家庄市科学技术研究与发展计划 （211460793）
通讯作者：杨　磊，E-mail：dp99449@163.com
更新日期/Last Update: 2022-05-31