[1]张　斌　钱春生.依达拉奉对重型颅脑损伤患者血浆8-iso-PGF2α水平的影响及其临床疗效观[J].中国临床神经外科杂志,2015,(03):153.[doi:10.13798/j.issn.1009-153X.2015.03.008]
　ZHANG Bin,QIAN Chun-sheng..Effect of edaravone on plasma level of 8-iso-prostaglandin-F2α and prognosis in patients with severe craniocerebral trauma[J].,2015,(03):153.[doi:10.13798/j.issn.1009-153X.2015.03.008]
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依达拉奉对重型颅脑损伤患者血浆8-iso-PGF2α水平的影响及其临床疗效观()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年03期
页码:
153
栏目:
论著
出版日期:
2015-03-30

文章信息/Info

Title:
Effect of edaravone on plasma level of 8-iso-prostaglandin-F2α and prognosis in patients with severe craniocerebral trauma
文章编号:
1009-153X（2015）03-0153-02
作者:
张　斌　钱春生
213200 江苏，金坛市人民医院神经外科
Author(s):
ZHANG Bin;  QIAN Chun-sheng.
Department of Neurosurgery, Jintan People’s Hospital, Jiangsu 213200, China
关键词:
颅脑损伤; 依达拉奉; 8-表氧前列腺素F2α; 预后
Keywords:
Craniocerebral trauma;  Endaravone;  8-iso-prostaglandin-F2α
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2015.03.008
文献标志码:
A
摘要:
目的 探讨依达拉奉对重型颅脑损伤（sTBI）患者血浆8-表氧前列腺素F2α（8-iso-PGF2α）水平的影响及其治疗sTBI的效果。方法 将60例sTBI患者随机分为观察组和对照组，每组30例。两组均给予常规治疗，包括脱水降颅压、止血、抗感染、降血糖、营养药物及手术等。观察组在常规治疗基础上给予新型抗氧化剂依达拉奉（30 mg，静脉滴注，2次/d，持续2周）。治疗后2、3、7、14、30 d采用酶联免疫吸附法检测血浆8-iso-PGF2α水平。治疗后14 d进行GCS评分，治疗后3个月按照GOS评分评估患者预后。结果 治疗后2 d，两组血浆8-iso-PGF2α水平均较治疗前显著升高（P<0.05），随后显著下降（>P<0.05），观察组显著低于对照组（（>P<0.05）。治疗后14 d，两组gcs评分均明显高于治疗前（P<0.05），观察组明显高于对照组（>P<0.05）。治疗后3个月，两组gos评分均明显高于治疗前（>P<0.05），观察组明显高于对照组（>P<0.05）。>结论 应用依达拉奉可显著降低sTBI患者血浆8-iso-PGF2α水平，改善患者预后。
Abstract:
Objective To explore the effects of endaravone on the prognoses and plasma level of 8-iso-prostaglandin-F2α (8-iso- PGF2α) in the patients with severe craniocerebral trauma. Methods Sixty patients with severe craniocerebral trauma were randomly divided into control group (n=30) and treatment group (n=30). The patients in both the groups were given routine therapy including dehydration, anti-inflammation, hemostasis, anti-infection, lowering the intracranial pressure, anti-diabetics treatment, nutritious drugs and surgeries. Based on this, 30 mg endaravone twice a day for was intravenously injected for 2 weeks, twice a day, in the treatment group. The plasma levels of 8-iso- PGF2α were determined before the treatment and 1, 2, 6, 13 and 29 days after the treatment. GCS was assessed respectively on the admission and 14 d after the treatment, and the prognoses were assessed by GOS 3 months after the treatment in all the patients. Results The plasma levels of 8-iso-PGF2α were significantly higher 1 day after the treatment than those before the treatment in both the (P<0.05), and="" they="" were="" significantly="" lower="" 2,="" 6,="" 13="" 29="" days="" after="" the="" treatment="" than="" those="" before="" in="" both="" groups="" (P<0.05). the="" plasma="" levels="" of="" 8-iso-pgf2α="" were="" significantly="" lower="" in="" treatment="" group="" than="" those="" control="" 6,="" 13="" and="" 29="" days="" after="" (P<0.01). the="" scores="" of="" gcs="" were="" significantly="" higher="" 13="" days="" after="" treatment="" than="" those="" before="" in="" both="" group="" (P<0.01). the="" scores="" of="" gcs="" were="" significantly="" higher="" in="" treatment="" group="" than="" those="" control="" 13="" days="" after="" (P<0.01). the="" scores="" of="" gos="" were="" significantly="" higher="" in="" treatment="" group="" than="" those="" control="" 3="" months="" after="" (P

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更新日期/Last Update: 2015-03-30