[1]穆林森　张红波　陈谦学　田道锋　徐海涛　李明昌　熊晓星　刘宝辉.原发灶来源不明的脑转移瘤的临床特点及治疗[J].中国临床神经外科杂志,2015,(12):733-735.[doi:10.13798/j.issn.1009-153X.2015.12.009]
　Mu Lin-sen,ZHANG Hong-bo,CHEN Qian-xue,et al.Clinical features and treatment of brain metastasis in patients with malignant tumors of unknown primary[J].,2015,(12):733-735.[doi:10.13798/j.issn.1009-153X.2015.12.009]
点击复制

原发灶来源不明的脑转移瘤的临床特点及治疗()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年12期
页码:
733-735
栏目:
论著
出版日期:
2015-12-30

文章信息/Info

Title:
Clinical features and treatment of brain metastasis in patients with malignant tumors of unknown primary
文章编号:
1009-153X（2015）12-0733-03
作者:
穆林森　张红波　陈谦学　田道锋　徐海涛　李明昌　熊晓星　刘宝辉
510370，广州市脑科医院神经外科（穆林森）；430015 武汉，湖北省中西医结合医院神经外科（张红波）；430060 武汉，武汉大学人民医院神经外科（陈谦学、田道锋、徐海涛、李明昌、熊晓星、刘宝辉）
通讯作者：张红波，E-mail：hongbozhang99@163.com
Author(s):
Mu Lin-sen1;  ZHANG Hong-bo2;  CHEN Qian-xue3;  TIAN Dao-feng3;  XU Hai-tao3;  LI Ming-chang3;  XIONG Xiao-xing3;  LIU Bao-hui1.
1. Department of Neurosurgery, Guangzhou Brain Hospital, Guangzhou 518370, China; 2. Department of Neurosurgery, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430015, China; 3. Department of Neurosurgery, Renmin Hospital, Wuh
关键词:
原发灶不明的脑转移瘤; 临床特征; 治疗
Keywords:
Brain metastasis;  Unknown primary malignant tumors;  Clinical features;  Treatment
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2015.12.009
文献标志码:
A
摘要:
目的 探讨原发灶来源不明的脑转移瘤（BMUP）的临床特点及治疗方法。方法 回顾性分析26例BMUP患者的临床资料。结果 病灶位于额叶8例、顶叶13例、枕叶1例、小脑3例、基底节区1例。19例单发转移灶全切除，7例多发灶者行症状侧病灶全切除术。术后均接受普通放疗，其中3例多发转移瘤加行替莫唑胺辅助化疗。术后随访6~78个月，平均28个月；复发7例（单发灶2例，多发灶5例），再次手术治疗2例，化疗3例，2例因颅内播散、恶性颅内压增高死亡。结论 BMUP影像学及病理学具有一定特征，治疗主要采取以手术为主的综合治疗，术后常规放化治疗可延缓肿瘤生长，提高患者生存率。
Abstract:
Objective To explore the clinical features and treatment of brain metastases from unknown primary malignant tumors. Method The clinical data of 26 patients with brain metastases from unknown primary malignant tumors were analyzed retrospectively, including their disease history, past history, clinical manifestations, laboratory examination, neuroimaging findings, treatment and pathology Results and so on. Results Of 26 cases of brain metastases, 8 were in the frontal lobes, 13 in the parietal lobes, 1 in the occipital lobe, 3 in the cerebellums and 1 in the basal ganglia. The solitary metastases were totally resected in 19 patients and the symptomatic foci were resected in 7 patients with multiple metastases. The adjuvant chemotherapy with temozolomid was performed in 3 patients with multiple metastases. All the patients were followed up from 6 to 78 months (mean, 28 months). Of 7 patients in whom the tumors recurred during the following-up, 5 had multiple metastases and 2 solitary metastases before the operation. Of 7 patients with recurrent tumors, 2 underwent surgery and 3 chemotherapy again and 2 died. Conclusions The brain metastases from the unknown primary tumors were clinically common. The brain metastases imaging and pathology are of certain characteristics. The postoperative conventional radiotherapy and chemotherapy are helpful to prolonging the survival time and improving the prognoses in the patients with brain metastases from unknown primary malignant tumors.

参考文献/References:

[1] Bartelt S, Lutterbach J. Brain metastases in patients with cancer of unknown primary [J]. J Neurooncol, 2003, 64: 249-253.
[2] Taillibert S, Le Rhun é. Epidemiology of brain metastases [J]. Cancer Radiother, 2015, 19(1): 3-9.
[3] Nussbaum ES, Djalilian HR, Cho KH, et al. Brain metas- tases: histology, multiplicity, surgery and survival [J]. Cancer, 1996, 78: 1781-1788.
[4] Milovic M, Popov I, Jelic S. Tumor markers in metastatic disease from cancer of unknown primary origin [J]. Med Sci Monit, 2002, 8: MT25-30.
[5] Nguyen, LN, Maor, MH, Oswald, MJ, et al. Brain metastases as the only manifestation of an undetected primary tumor [J]. Cancer, 1998, 83(10): 2181-2184.
[6] Agazzi S, Pampallona S, Pica A, et al. The origin of brain metastases in patients with an undiagnosed primary tumour [J]. Acta Neurochir (Wien), 2004, 146: 153-157.
[7] Bergner N, Romeike BF, Reichart R, et al. Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines [J]. Analyst, 2013, 138(14): 3983-3990.
[8] Fujimaki T. Surgical treatment of brain metastasis [J]. Int J Clin Oncol, 2005, 10(2): 74-80.
[9] Maesawa S, Kondziolka D, Thompson T, et al. Brain metas- tases in patients with no known primary tumor. The role of stereotactic radiosurgery [J]. Cancer, 2000, 89:1095-1101.
[10] Kyritsis AP, Markoula S, Levin VA, et al. A systematic approach to the management of patients with brain metas tases of known or unknown primary site [J]. Cancer Chemo- ther Pharmacol, 2012, 69(1): 1-13.

相似文献/References:

[1]刘　琦　郝东宁　周　峰　王　鹏　曾　文　李维新.颈椎前路融合术后相邻节段退变的临床分析[J].中国临床神经外科杂志,2015,(11):665.[doi:10.13798/j.issn.1009-153X.2015.11.008]
　LIU Qi,HAO Dong-ning,ZHOU Feng,et al.Clinical analysis of adjacent segment degeneration after anterior cervical vertebral fusion[J].,2015,(12):665.[doi:10.13798/j.issn.1009-153X.2015.11.008]
[2]刘　征　张新元　伍　杰　王在贵　徐国政.复发胶质瘤恶性进展的回顾性分析[J].中国临床神经外科杂志,2016,(04):230.[doi:10.13798/j.issn.1009-153X.2016.04.012]
[3]娄元华　李小勇　陈红伟　潘栋超　解东成　刘东升.婴儿脑积水分流术后硬膜下积液的临床分析[J].中国临床神经外科杂志,2016,(04):245.[doi:10.13798/j.issn.1009-153X.2016.04.019]
[4]孙成法　姜　华　褚荣涛　金　科.671例慢性硬膜下血肿的临床分析[J].中国临床神经外科杂志,2016,(01):42.[doi:10.13798/j.issn.1009-153X.2016.01.015]
[5]袁学刚　陈志勇　秦君翔　肖　胜　王　璨　黄锦峰　刘　斌　喻军华.亚急性硬膜下血肿17例临床分析[J].中国临床神经外科杂志,2016,(08):491.[doi:10.13798/j.issn.1009-153X.2016.08.017]
[6]陈福业　丰育功　张丕宁　李环廷　栗世方　郭　品　张洪亮　江俊莹.颅骨海绵状血管瘤20例分析[J].中国临床神经外科杂志,2017,(12):839.[doi:10.13798/j.issn.1009-153X.2017.12.012]
[7]华　刚　谭红平　张立民　杨　琪　郭　强　朱　丹.脑裂头蚴病的诊断和手术治疗体会[J].中国临床神经外科杂志,2018,(03):191.[doi:10.13798/j.issn.1009-153X.2018.03.017]
[8]秦　汉　胡军民　元　玲　秦海林　安学锋　雷　颉.多形性黄色瘤型星形细胞瘤的诊治分析：附7例报道并文献复习[J].中国临床神经外科杂志,2019,(12):721.[doi:10.13798/j.issn.1009-153X.2019.12.001]
　QIN Han,HU Jun-min,YUAN Ling,et al.Diagnosis and treatment of pleomorphic xanthoastrocytomas and review of literature related to them (report of 7 cases)[J].,2019,(12):721.[doi:10.13798/j.issn.1009-153X.2019.12.001]
[9]邹文辉　李俊驹　黄垂学.中枢神经系统类鼻疽病的临床特点分析[J].中国临床神经外科杂志,2020,(03):144.[doi:10.13798/j.issn.1009-153X.2020.03.005]
　ZOU Wen-hui,LI Jun-ju,HUANG Chui-xue..Analysis of clinical characteristics of central nervous system melioidosis (report of 12 cases)[J].,2020,(12):144.[doi:10.13798/j.issn.1009-153X.2020.03.005]
[10]胡承啸　高玉松　曾　红　闫德祺.脑静脉系统血栓形成伴颅内出血的临床特征及治疗[J].中国临床神经外科杂志,2021,26(08):587.[doi:10.13798/j.issn.1009-153X.2021.08.005]
　HU Cheng-xiao,GAO Yu-song,ZENG Hong,et al.Clinical characteristics and treatment of cerebral vein and dual sinus thrombosis associated with intracranial hemorrhage[J].,2021,26(12):587.[doi:10.13798/j.issn.1009-153X.2021.08.005]

更新日期/Last Update: 2016-12-30