[1]刘　强　雷勋明　陈全景　陈少军　李　旭.内关穴针刺治疗痉挛性脑瘫患儿的疗效及对血清脑源性神经营养因子的影响[J].中国临床神经外科杂志,2017,(04):231-233,236.[doi:10.13798/j.issn.1009-153X.2017.04.008]
　LIU Qiang,LEI Xun-ming,CHEN Quan-jing,et al.Effects of acupuncture of Neiguan points on serum level of brain-derived neurotrophic factor in children with spastic cerebral palsy[J].,2017,(04):231-233,236.[doi:10.13798/j.issn.1009-153X.2017.04.008]
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内关穴针刺治疗痉挛性脑瘫患儿的疗效及对血清脑源性神 经营养因子的影响()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年04期
页码:
231-233,236
栏目:
论著
出版日期:
2017-04-25

文章信息/Info

Title:
Effects of acupuncture of Neiguan points on serum level of brain-derived neurotrophic factor in children with spastic cerebral palsy
文章编号:
1009-153X（2017）04-0231-03
作者:
刘　强　雷勋明　陈全景　陈少军　李　旭
442000 湖北十堰，湖北医药学院附属东风总医院儿童医疗中心
Author(s):
LIU Qiang;  LEI Xun-ming;  CHEN Quan-jing;  CHEN Shao-jun;  LI Xu.
Children’s Medical Center, Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442000, China
关键词:
痉挛性脑瘫; 内关穴; 针刺治疗; 脑源性神经营养因子; 智力
Keywords:
Spastic cerebral palsy;  Neiguan points;  Acupuncture therapy;  Brain-derived neurotrophic factor;  Curative effect
分类号:
R 742.3
DOI:
10.13798/j.issn.1009-153X.2017.04.008
文献标志码:
A
摘要:
目的 探讨内关穴针刺治疗痉挛性脑瘫患儿的疗效及对血清脑源性神经营养因子（BDNF）的影响。方法 2012年3月至2016年3月收治痉挛性脑瘫患儿72例，根据随机信封抽签法分为观察组与对照组，各36例。对照组给予常规治疗，观察组在对照组治疗的基础上给予内关穴针刺治疗，两组治疗观察时间为3个月。结果 观察组总有效率（97.2%）明显高于对照组（77.8%；P<0.05）。观察组与对照组治疗前适应行为与语言行为评分、血清BDNF水平均无统计学差异（P<0.05）；治疗后，两组适应行为与语言行为评分、血清BDNF水平较治疗前均明显增高（P<0.05），而且观察组治疗后评分、血清BDNF水平均明显高于对照组（P<0.05）。结论 内关穴针刺治疗痉挛性脑瘫患儿能提高治疗效果，促进智力发育，其机制可能与促进BDNF的表达有关。
Abstract:
Objective To investigate effects of acupuncture of Neiguan points on the serum level of brain-derived neurotrophic factor (BDNF) in children with spastic cerebral palsy. Methods Seventy-two children with spastic cerebral palsy who were treated in our hospital from March, 2012 to March, 2016, were randomly divided into two groups of thirty-six children each, i.e. observed group in which the children were treated by acupuncture of Neiguan points on the basis of routine treatment and control group in which the children received the routine treatment. The serum levels of BDNF were determined by ELISA in all the children and the curative effects were compared between both the groups 3 months after the treatment. Results The total effective rate (97.2%, 35/36) was significantly higher in the observed group than that (77.8%, 28/36) in the control group (P<0.05). The serum level of BDNF [(4.92±1.39) ng/ml] were significantly higher in the observed group than that [(4.56±1.09) ng/ml] in the control group (P<0.05) 3 months after the treatment. The serum levels of BDNF were significantly higher 3 months after the treatment than those before the treatment in the observed and control groups. The adaptation and language behavior scores in the observed group [(87.24±4.29) points and (84.25±3.84) points respectively] were significantly higher respectively than those in the control group [(76.20±5.11) points and (77.02±4.19) points respectively] (P<0.05) after the treatment. The adaptation and language behavior scores after the treatment were significantly higher than those before the treatment in the two groups (P<0.05). Conclusion That the acupuncture of Neiguan points in children with spastic cerebral palsy is very helpful to improvement of the curative effect and promoting mental development may be related with the increased expression of BDNF produced by the acupuncture of Neiguan points.

参考文献/References:

[1] Koh H, Hwang K, Lim HY, et al. Mononuclear cells from the cord blood and granulocytecolony stimulating factor- mobilized peripheral blood: is there a potential for treat- ment of cerebral palsy [J]? Neural Regen Res, 2015, 10(12): 2018-2024.
[2] 赵利华，李雅彦，黄　瑜，等. 不同进针法针刺内关穴对简 式 McGill 疼痛问卷表评分及心血管功能的影响[J]. 上海 针灸杂志，2016，35（5）：625-628.
[3] Zhang Y, Lan R, Wang J, et al. Acupuncture reduced apop- tosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia-ischemia in neonatal rats [J]. J Ethnopharmacol, 2015, 22(172): 124-132.
[4] Chung Y, So K, Kim E, et al. Immunoreactivity of neurogenic factor in the guinea pig brain after prenatal hypoxia [J]. Ann Anat,2015, 200(2): 66-72.
[5] 张姝妤. 小儿脑瘫60例针刺配合运动疗法的临床观察 [J]. 中国实用医刊，2016，43（7）：41-42.
[6] 石立业，尚　清，马彩云. 内关穴针刺治疗痉挛性脑瘫患 儿精细运动障碍临床研究[J]. 中医临床研究，2016，8 （5）：4-6.
[7] Bachnas MA, Mose JC, Effendi JS, et al. Influence of ante- natal magnesium sulfate application on cord blood levels of brain-derived neurotrophic factor in premature infants [J]. J Perinat Med, 2014, 42(1): 129-134.
[8] Hung PL, Huang CC, Huang HM, et al. Thyroxin treatment protects against white matter injury in the immature brain via brain-derived neurotrophic factor [J]. Stroke, 2013, 44 (8): 2275-2283.
[9] 陈　栋，鲍　超，陆　斌，等. “补肾健脑针法”结合言语训 练对脑瘫患儿言语障碍临床观察[J]. 浙江中医药大学学 报，2016，40（6）：491-493.
[10] Jiang PF, Zhu T, Gao JD, et al. The effect of maternal infec- tion on cognitive development and hippocampus neuronal apoptosis, proliferation and differentiation in the neonatal rats [J]. Neuroscience, 2013, 29(246): 422-434.
[11] 陈　丹. 针刺联合康复训练改善脑瘫患儿运动功能临床 观察[J]. 针灸临床杂志，2016，32（4）：34-35.
[12] Passemard S, Sokolowska P, Schwendimann L, et al. VIP- induced neuroprotection of the developing brain [J]. Curr Pharm Des, 2011,17(10): 1036-1039.
[13] 谭晓如，刘振寰，李汝鸿，等. 针刺配合作业治疗改善痉 挛型脑瘫患儿精细功能的观察[J]. 针灸推拿医学（英文 版），2016，14（5）：328-332.
[14] Burgos-Vega CC, Quigley LD, Avona A, et al. Dural stimu- lation in rats causes brain-derived neurotrophic factor- dependent priming to subthreshold stimuli including a migraine trigger [J]. Pain, 2016, 157(12): 2722-2730.
[15] 金炳旭，刘振寰，赵　勇，等. 针刺辅助治疗对不同类型脑 瘫患儿运动功能疗效相关因素分析—附520例回顾性分 析[J]. 中国针灸，2016，36（7）：709-714.
[16] Nardone R, Orioli A, Golaszewski S, et al. Passive cycling in neurorehabilitation after spinal cord injury: a review [J]. J Spinal Cord Med, 2016. Epub ahead of print.
[17] 杜　翔，梁　松，吴兆芳，等. 子午流注纳甲法针刺治疗痉 挛型脑性瘫痪患儿的疗效观察[J]. 针刺研究，2016，41 （5）：462-465.
[18] Poletti S, Aggio V, Hoogenboezem TA, et al. Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder [J]. Eur Psychiatry, 2016, 9(40): 33-37.
[19] Zhang JC, Yao W, Dong C, et al. Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation [J]. J Nutr Biochem, 2016, 11(39):134-144.
[20] Yoneda M, Sugimoto N, Katakura M, et al. Theobromine up- regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice [J]. J Nutr Biochem, 2016, 8(39):110-116.

备注/Memo

备注/Memo:
基金项目：湖北省教育厅科研课题（B2014049）
通讯作者：雷勋明，E-mail：leixunming56@163.com
更新日期/Last Update: 2017-04-25