[1]钱春生　张　斌　钱腾达　何云文　李益欢　董吉荣.血清N-端脑钠肽前体评估颅脑损伤预后的价值[J].中国临床神经外科杂志,2017,(04):234-236.[doi:10.13798/j.issn.1009-153X.2017.04.009]
　QIAN Chun-sheng,ZHANG Bin,QIAN Teng-da,et al.Relationship between plasma level of N-terminal pro-brain natriuretic peptide and the prognosis in patients with traumatic brain injury[J].,2017,(04):234-236.[doi:10.13798/j.issn.1009-153X.2017.04.009]
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血清N-端脑钠肽前体评估颅脑损伤预后的价值()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年04期
页码:
234-236
栏目:
论著
出版日期:
2017-04-25

文章信息/Info

Title:
Relationship between plasma level of N-terminal pro-brain natriuretic peptide and the prognosis in patients with traumatic brain injury
文章编号:
1009-153X（2017）04-0234-03
作者:
钱春生　张　斌　钱腾达　何云文　李益欢　董吉荣
213200 江苏常州，江苏大学附属金坛医院神经外科（钱春生、张　斌、钱腾达、何云文、李益欢）；214000 江苏无锡，中国人民解放军第101医院神经外科（董吉荣）
Author(s):
QIAN Chun-sheng1;  ZHANG Bin1;  QIAN Teng-da1;  HE Yun-wen1;  LI Yi-huan1;  DONG Ji-rong2.
1. Department of Neurosurgery, Jintan Hospital Affiliated to Jiangsu University, Changzhou 213200, China;
2. Department of Neurosurgery, The 101st Hospital, PLA, Wuxi 214000, China
关键词:
颅脑损伤; N-端脑钠肽前体; 血清水平; 预后; 预测
Keywords:
Traumatic brain injury;  N-terminal pro-brain natriuretic peptide;  Severity;  Plasma level;  Prognosis
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2017.04.009
文献标志码:
A
摘要:
目的 探讨血清N-端脑钠肽前体（NT-proBNP）在颅脑损伤预后评估中的价值。方法 选取2013年2月至2015年12月收治的100例颅脑损伤作为观察组，同期健康体检者100例作为对照组；采集入院时清晨空腹静脉血检测血清NT-proBNP水平；绘制受试者工作特征（ROC）曲线判断NT-proBNP在预测颅脑损伤死亡的价值。结果 观察组血清NT-proBNP水平[（140.9±53.8）pg/ml]显著地高于对照组[（32.5±19.3）pg/ml；P<0.05]。轻型、中型、重型颅脑损伤病人血清NT-proBNP水平分别为（86.2±31.5）、（145.9±47.2）、（245.9±61.3）pg/ml，两两比较均有统计学差异（P<0.05）。100例颅脑损伤中，死亡24例，病死率为24%；死亡病人血清NT-proBNP水平[（259.3±67.8）pg/ml]显著高于存活病人[（100.4±59.7）pg/ml；P<0.05]。ROC曲线分析表明NT-proBNP判定颅脑损伤死亡的最佳临界值为144.8 pg/ml，灵敏度为81.53%，特异度为91.47%。结论 颅脑损伤病人血清NT-proBNP水平显著增高，与损伤程度有一定关系；血清NT-proBNP水平是有效预测颅脑损伤死亡结局的有效指标。
Abstract:
Objective To investigate the relationship of the plasma level of N-terminal pro-brain natriuretic peptide (NT-proBNP) with the severity and prognosis in the patients with traumatic brain injury (TBI). Methods The fasting venous blood plasma levels of the NT-proBNP were detected by electrochemiluminescence method in 100 patients with TBI, of whom, 42 suffered from mild TBI, 37 moderate TBI and 21 severe TBI, and 100 healthy subjects from February, 2013 to December, 2015. The relationship of the plasma levels of NT-proBNP with injury severity degree and prognosis were analyzed. Results The plasma level of NT-proBNP [(140.9±53.8) pg/ml] was significantly higher in the patients with TBI than that [(32.5±19.3) pg/ml] in the healthy subjects (P<0.05). The plasma level of NT-proBNP [(245.9±61.3) pg/ml] in patients with severe TBI was significantly higher than that [(145.9±47.2) pg/ml] in the patients with moderate TBI (P<0.05), which was significantly higher than that [(86.2±31.5) pg/ml] in the patients with mild TBI (P<0.05). The plasma level of NT-proBNP [(259.3±67.3) pg/ml] was significantly higher in the dead patients (n=24) than that [(100.4±59.7) pg/ml] in the survival patients (P<0.05). The area under receiver operating characteristic curve of NT-proBNP levels predicting death of patients with TBI was AUC=0.932, 95%CI (0.814 ~ 0.971). The best critical value of NT-proBNP determining death of patients with TBI was 144.8 pg/ml, and the corresponding sensitivity and specificity were 81.53% and 91.47% respectively. Conclusions The determination of the plasma NT-proBNP levels is very helpful to assessment of injury severity in the patients with TBI. It is suggested that the plasma level of NT-proBNP is of the important value to predicting the clinical treatment outcomes in the patients with TBI.

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更新日期/Last Update: 2017-04-25