[1]淦 超 李朝曦 陈 娟 徐 钰 张华楸 雷 霆.女性泌乳素腺瘤手术预后的影响因素分析[J].中国临床神经外科杂志,2017,(06):395-397.[doi:10.13798/j.issn.1009-153X.2017.06.009]
 GAN Chao,LI Chao-xi,CHEN Juan,et al.Risk factors for prognosis of female prolactinoma patients after transphenoidal surgery[J].,2017,(06):395-397.[doi:10.13798/j.issn.1009-153X.2017.06.009]
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女性泌乳素腺瘤手术预后的影响因素分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年06期
页码:
395-397
栏目:
论著
出版日期:
2017-06-25

文章信息/Info

Title:
Risk factors for prognosis of female prolactinoma patients after transphenoidal surgery
文章编号:
1009-153X(2017)06-0395-03
作者:
淦 超 李朝曦 陈 娟 徐 钰 张华楸 雷 霆
430030 武汉,华中科技大学同济医学院附属同济医院神经外科
Author(s):
GAN Chao LI Chao-xi CHEN Juan XU Yu ZHA NG Hua-qiu LEI Ting
Department of Neurosurgery, Tongji Hospital, Tongji Medical School, Huazhong University of Sciences and Technology, Wuhan 400030, China
关键词:
垂体腺瘤泌乳素腺瘤女性经蝶手术预后影响因素
Keywords:
Prolactinoma Female Transphenoidal surgery Prognosis Risk factor
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2017.06.009
文献标志码:
A
摘要:
目的 探讨女性泌乳素腺瘤病人经蝶手术预后的影响因素。方法 回顾性分析2011~2014年首次行手术治疗的138例女性泌乳素腺瘤病人的临床资料。结果 138例术后初始缓解率为80.4%,超过3个月第一次随访术后缓解率为80.7%。术前泌乳素<500 ng/ml病人初始缓解为95.3%,随访术后缓解率为87.6%。无海绵窦侵袭生长的微腺瘤初始缓解率为93.9%,随访术后缓解率为91.3%。多因素Logistic回归分析显示肿瘤侵犯海绵窦、术前高泌乳素血症是女性泌乳素腺瘤手术效果的独立影响因素(P<0.05)。114例术后随访3~51个月,平均(20.1±12.3)个月;第一次随访术后缓解的病人5例复发,复发率为5.4%。结论 对具备手术指征的无海绵窦侵犯、术前泌乳素<500 ng/ml的女性泌乳素腺瘤,经鼻蝶手术治疗能取得极佳的疗效。
Abstract:
Objective To explore the independent risk factors for the prognosis of female prolactinoma patients treated by transsphenoidal surgery. Methods The clinical data of 138 female prolactinoma patients, who firstly underwent surgery from 2011 to 2014, were analyzed retrospectively. Results The initial remission rate was 80.4% in 138 patients. The remission rate was 80.7% 3 months after surgery. Of the patient with preoperative prolactin <500 ng/ml, the initial remission rate was 95.3%, and 3-month postoperative remission rate was 87.6%. The initial remission rate of micro-adenoma without cavernous sinus invasion was 93.9%, and the remission rate was 91.3% 3 moths after suregry. Multivariate Logistic regression analysis showed that tumor invasion of cavernous sinus and preoperative hyperprolactinemia were independent risk factors for the prognosis (P<0.05). Of 114 patients followed up for 3 to 51 months (mean, 20.1±12.3 months), the recurrence rate was 5.4%. Conclusion The transphenoidal surgery is a good choice for female prolactinoma patients without cavernous sinus invasion or with preoperative prolactin less than 500 ng/ml.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者:雷 霆,E-mail: tlei@tjh.tjmu.edu.cn
更新日期/Last Update: 2017-06-25