[1]徐 成,刘 羽,谢 涛,等.恶性脑膜瘤的治疗及预后影响因素分析（附34例报道）[J].中国临床神经外科杂志,2018,(10):641-643.[doi:10.13798/j.issn.1009-153X.2018.10.001]
　XU Cheng,LIU Yu,XIE Tao,et al.Treatment and factors related to prognoses in patients with malignant meningiomas (report of 34 cases)[J].,2018,(10):641-643.[doi:10.13798/j.issn.1009-153X.2018.10.001]
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恶性脑膜瘤的治疗及预后影响因素分析（附34例报道）()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年10期
页码:
641-643
栏目:
论著
出版日期:
2018-10-25

文章信息/Info

Title:
Treatment and factors related to prognoses in patients with malignant meningiomas (report of 34 cases)
文章编号:
1009-153X（2018）10-0641-03
作者:
徐 成; 刘 羽; 谢 涛; 刘俊峰; 罗龙军; 叶 飞
430030 武汉，华中科技大学同济医学院附属同济医院神经外科（徐 成、刘俊峰、罗龙军、叶 飞）；430000，武汉市中心医院神经外科（刘 羽）；433100 湖北，潜江市中心医院神经外科（谢 涛）
Author(s):
XU Cheng1;  LIU Yu2;  XIE Tao3;  LIU Jun-feng1;  LUO Long-jun1;  YE Fei1.
1. Department of Neurosurgery, Tongji Hospital, Tongji Medical School, Huazhong University of Sciences and Technology, Wuhan 430030, China; 2. Department of Neurosurgery, Wuhan Municipal Central Hospital, Wuhan 430000, China; 3. Department of Neurosurgery, Qianjiang Municipal Central Hospital, Qianjiang 433100, China
关键词:
恶性脑膜瘤; 手术治疗; 放疗; 预后
Keywords:
Malignant meningiomas;  Surgical treatment;  Radiotherapy;  Prognosis
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2018.10.001
文献标志码:
A
摘要:
目的 探讨颅内恶性脑膜瘤的临床特点、影像学特点、治疗手段及预后影响因素。方法 回顾性分析2008年4月至2018年4月开颅手术肿瘤的34例恶性脑膜瘤的临床资料。结果 肿瘤全切（Simpson Ⅰ~Ⅲ级）20例，非全切（Simpson Ⅳ~Ⅴ）14例；术后行放疗19例，未行放疗15例。术后病理示，横纹肌样恶性脑膜瘤17例，乳头型恶性脑膜瘤6例，间变型恶性脑膜瘤11例。生存曲线分析显示，肿瘤全切病人生存期较非全切病人明显延长（P=0.002）；术后放疗病人生存期较未放疗病人延长，但无统计学差异（P=0.078）。结论 对恶性脑膜瘤的治疗，手术切除程度至关重要，直接影响病人生存期；术后放疗可抑制肿瘤短期内复发，但对病人长期预后无显著影响。
Abstract:
Objective To explore the clinical manifestations, imaging features, treatment and factors related to prognoses in patients with intracranial malignant meningiomas (ICMM). Methods The clinical data of 34 patients with ICMM undergoing craniotomy in Tongji Hospital from April, 2008 to April, 2018 were analyzed retrospectively. The factors related to prognoses were statistically analyzed in the patients with ICMM. Results Of 34 patients with ICMM, 17 were rhabdoid malignant meningiomas, 6 papillary malignant meningiomas, and 11 metastatic malignant meningiomas. The tumors were totally resected (Simpson grades Ⅰ~Ⅲ) in 20 patients and subtotally (Simpson Ⅳ~Ⅴ) in 14. Of these 34 patients, 19 received radiotherapy and 15 not after the surgery. The survival time were significantly longer in patients with ICMM receiving totally resection of the tumor than those in the patient with ICMM who received incomplete resection of the tumors. Conclusions The extent of surgical resection of the tumors is the key to prolonging the survival time, and the postoperative radiotherapy can inhibit the recurrence of tumors in the short term, but it has no significant effect on the long-term prognoses in the patients with ICMM.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：叶 飞，E-mail：yeyuanbei@hotmail.com
更新日期/Last Update: 2018-09-30