[1]刘　芳　刘　莺.EPO联合亚低温治疗新生儿缺氧缺血性脑病的疗效分析[J].中国临床神经外科杂志,2018,(12):795-797.[doi:10.13798/j.issn.1009-153X.2018.12.010]
　LIU Fang,LIU Ying..Effect of erythropoietin combined with hypothermic treatment on neonates with hypoxic-ischemic encephalopathy[J].,2018,(12):795-797.[doi:10.13798/j.issn.1009-153X.2018.12.010]
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EPO联合亚低温治疗新生儿缺氧缺血性脑病 的疗效分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年12期
页码:
795-797
栏目:
论著
出版日期:
2018-12-25

文章信息/Info

Title:
Effect of erythropoietin combined with hypothermic treatment on neonates with hypoxic-ischemic encephalopathy
文章编号:
1009-153X（2018）12-0795-03
作者:
刘　芳　刘　莺
435000 湖北黄石，鄂东医疗集团黄石市中心医院（湖北理工学院附属医院）儿科（刘　芳、刘　莺）
Author(s):
LIU Fang;  LIU Ying.
Pediatrics Department, Huangshi Munipal Central Hospital, E’ Dong Health Care Grong, Huangshi 435000, China
关键词:
缺氧缺血性脑病; 促红细胞生成素; 亚低温治疗; Tau蛋白; 神经发育
Keywords:
Hypoxic-ischemic encephalopathy;  Neonates;  Erythropoietin;  Hypothermia;  Tau protein;  Neuroligical development
分类号:
R742.3
DOI:
10.13798/j.issn.1009-153X.2018.12.010
文献标志码:
A
摘要:
目的 探讨促红细胞生成素（EPO）联合亚低温治疗新生儿缺氧缺血性脑病（HIE）的疗效。方法 选取2014年2月至2017年4月收治的HIE患 儿98例，依据治疗方案分为联合组（n=34）、亚低温组（n=30）和EPO组（n=34）；亚低温组患儿采用亚低温治疗，EPO组患儿采用EPO治疗，联合组 患儿采用EPO联合亚低温治疗。治疗前和治疗后2、7、14、28 d，采用新生儿神经行为（NBNA）评分评估神经行为发育，采用酶联免疫吸附试验法检 测血清Tau蛋白水平。结果 治疗后7、14、28 d，三组NBNA评分较治疗前均明显增高（P<0.05），血清Tau蛋白水平均明显下降（P<0.05）；而且，联 合组明显优于亚低温组和EPO组（P<0.05）。Spearman相关性分析显示，治疗后7、14、28 d，患儿NBNA评分与血清Tau蛋白水平均呈明显负相关 （P<0.05）。结论 EPO联合亚低温治疗有效改善新生儿神经发育，血清Tau蛋白水平测定可作为协助评价神经发育结局的临床指标。
Abstract:
Objective To investigate the effect of erythropoietin (EPO) combined with hypothermic treatment on serum Tau protein levels in the neonates with hypoxic-ischemic encephalopathy (HIE). Methods Of 98 neonates with HIE treated in Department of Neonatology in our hospital from February, 2014 to April, 2017, 30 (hypothermia group) were treated alone by hypothermia, 34 (EPO group) alone by reconstruction human (rh) EPO, and 34 (combination group) by rhEPO combined with hypothermia. The serum Tau protein levels were detected and Neonatal behavioral neurological assessment (NBNA) were performed before and 2, 7, 14, and 28 days after the treatment. The relationship between the serum Tau protein level and NBNA scores was analyzed. Results The serum Tau protein levels were significantly lower and the NBNA scores were significantly higher in the combination group than those in the hypothermia and EPO groups 7, 14 and 28 days after the treatment (P<0.05). Spearman correlation analysis showed that the serum Tau protein levels were negatively correlated with NBNA scores in all the groups (P<0.05). Conclusions EPO combined with hypothermia can significantly reduce serum Tau protein levels and effectively improve neurological development in the neonates with HIE. The serum Tau protein level can be used as a clinical indicator to evaluate the neurobehavioral development outcomes in the neonates.

参考文献/References:

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备注/Memo

备注/Memo:
doi:10.13798/j.issn.1009-153X.2018.12.010 作者单位：435000 湖北黄石，鄂东医疗集团黄石市中心医院（湖北理工学院附属医院）儿科（刘　芳、刘　莺） 通讯作者：刘　莺，E-mail：373294532@qq.com
更新日期/Last Update: 2018-12-26