[1]赵雅娜 刘 伟 窦秀云 赵 红 魏 洁 张 莉 李翠花 窦玲云.促红细胞生成素联合甲强龙对脊髓损伤病人神经功能的影响[J].中国临床神经外科杂志,2019,(12):737-739.[doi:10.13798/j.issn.1009-153X.2019.12.006]
 ZHAO Ya-na,LIU Wei,DOU Xiu-yun,et al.Effects of erythropoietin combined with methylprednisolone on neurological function in patients with spinal cord injury[J].,2019,(12):737-739.[doi:10.13798/j.issn.1009-153X.2019.12.006]
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促红细胞生成素联合甲强龙对脊髓损伤病人神经功能的影响()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年12期
页码:
737-739
栏目:
论著
出版日期:
2019-12-24

文章信息/Info

Title:
Effects of erythropoietin combined with methylprednisolone on neurological function in patients with spinal cord injury
文章编号:
1009-153X(2019)12-0737-03
作者:
赵雅娜 刘 伟 窦秀云 赵 红 魏 洁 张 莉 李翠花 窦玲云
063000 河北,唐山市第二医院骨科(赵雅娜、刘 伟、窦秀云、赵 红、魏 洁、张 莉、李翠花、窦玲云)
Author(s):
ZHAO Ya-na LIU Wei DOU Xiu-yun ZHAO Hong WEI Jie ZHANG Li LI Cui-hua DOU Ling-yun.
Department of Orthopaedics, Tangshan Municipal Second Hospital, Tangshan 063000, China
关键词:
脊髓损伤促红细胞生成素甲强龙神经功能并发症
Keywords:
Erythropoietin Methylprednisolone Spinal cord injury Neurological function Complications
分类号:
R 744.9
DOI:
10.13798/j.issn.1009-153X.2019.12.006
文献标志码:
A
摘要:
目的 探讨促红细胞生成素(EPO)联合甲强龙对脊髓损伤(SCI)病人神经功能的影响。方法 回顾性分析2018年1~12月收治的60例SCI的临床资料。采用EPO联合甲强龙治疗30例(观察组),单用甲强龙治疗30例(对照组)。甲强龙首次用量30 mg/kg,在15 min内静脉注射,1 h后以5.4 mg/(kg·h)维持治疗24 h后;EPO治疗,3 000 IU/次,3次/周,持续8周。治疗前及治疗后1个月按照美国脊髓损伤协会(ASIA)评分评估神经功能,采用日常生活活动能力(ADL)评分评估生活能力。治疗前、治疗后2周检测红细胞和血红蛋白水平,准确记录两组病人治疗2周内并发症情况。结果 治疗前,两组ASIA评分、ADL评分、红细胞、血红蛋白水平均无统计学差异(P>0.05)。治疗后,两组ASIA评分、ADL评分、红细胞、血红蛋白水平均明显增高(P<0.05),而且,观察组明显高于对照组(P<0.05)。观察组并发症发生率明显低于对照组(P<0.05)。结论 EPO联合甲强龙治疗有利于促进SCI病人神经功能的恢复,减少并发症,具有很好的临床疗效。
Abstract:
Objective To explore the effects of erythropoietin (EPO) combined with methylprednisolone (MPS) on the neurological function in patients with spinal cord injury (SCI). Methods Sixty patients with SCI treated in our department from January to December, 2018 were divided into control group in which 30 patients were treated by MPS and routine treatment and observed group in which 30 patients were treated by EPO on the basis of treatment given to the control group. The neurological function and prognosis were assessed respectively by American Spinal Cord Injury Association (ASIA) score and activities of daily living (ADL) score, and The levels of erythcyte and hemoglobinin (Hb) in the peripheral blood were determined 8 weeks after the treatment. Results The scores of ASIA and ADL, and the levels of erythrocyte and Hb in the peripheral blood were significantly higher in the observed group than those in the control group 8 weeks after the treatment (P<0.05).The incidence of respiratory tract infection and bacteremia were significantly lower in the observed group than those in the control group after the treatment (P<0.05). Conclusions The treatment with EPO combined with MPS can promote the recovery of neurological function and reduce the incidence of complications in the patients with SCI.

参考文献/References:

[1] 杨天潇,缪 绯,李志聪,等. 促红细胞生成素对缺氧复氧 心肌细胞的保护作用及其机制[J]. 热带医学杂志,2014, 14(5):627-630.
[2] 罗坤烈,陆茂德,仇继任,等. 大剂量甲强龙、外科减压及 两者联合治疗颈椎无骨折脱位脊髓损伤的临床研究[J]. 临床医学,2016,36(3):55-56.
[3] 郭昌军,程朝辉,张富国. 促红细胞生成素联合甲强龙治 疗脊髓缺血再灌注损伤效果分析[J]. 医学研究杂志, 2016,45(7):75-79.
[4] 朱庄臣,焦 伟,蔡国栋,等. 大剂量甲强龙治疗急性脊髓 损伤后早期并发症的研究[J]. 中国矫形外科杂志,2014, 22(16):1454-1457.
[5] 鞠 飞,赵海苹,罗玉敏. 促红细胞生成素在神经系统疾 病治疗中的临床研究[J]. 实用药物与临床,2017,20(3): 339-344.
[6] 王 鹏,孙桂森,郭隆升,等. 急性脊髓损伤的药物治疗 [J]. 医学与哲学(B),2017,38(06):72-75.
[7] Frankel脊髓损伤分级[J]. 临床神经外科杂志,2010,7 (2):97.
[8] Harvey L. International standards for the neurological classification of spinal cord injury [J]. J Physiotherapy, 2011, 57(2): 129.
[9] 赵红卫,许 涛,方 煌,等. 美国脊髓损伤协会损伤分级 与脊髓运动损伤程度的相关性研究[J]. 中国康复医学杂 志,2004,19(4):42-43.
[10] 李 涛,董传江. 周围神经损伤后促红细胞生成素、他克 莫司、维生素B12及甲强龙对神经再生的作用[J].海南医 学,2018,29(12):1735-1738.
[11] 贺楚梅,阳前军,戢秋明,等. 精神病病人基于日常生活能 力评定量表分级护理的效果观察[J]. 护理学报,2017, 24(8):40-43.
[12] 杨 强,方 健,王海峰,等. 促红细胞生成素治疗急性脊 髓损伤的临床研究[J]. 医学信息,2018,31(11):70-72.
[13] 曹 鹏,石长贵,袁 文. 甲基强的松龙在急性脊髓损伤 中的应用进展[J]. 中国脊柱脊髓杂志,2015,25(2):174- 178.
[14] 刘 焰. 促红细胞生成素联合醒脑静注射液对阿尔茨海 默病病人认知功能的影响[J]. 现代中西医结合杂志, 2015,24(27):3025-3026,3049.

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备注/Memo

备注/Memo:
基金项目:河北省医学科学研究重点课题计划项目(20181278) 通讯作者:刘 伟,E-mail:27861920@qq.com (2019-08-14收稿,2019-09-29修回)
更新日期/Last Update: 2019-12-23