[1]李　琳　刘　玮　洪　畋　刘佳妮　葛小金　王　芳.卒中相关性肺炎血清炎症因子和外周血淋巴细胞亚群的分析[J].中国临床神经外科杂志,2019,(12):740-742.[doi:10.13798/j.issn.1009-153X.2019.12.007]
　LI Lin,LIU Wei,LIU Jia-ni,et al.Analysis of serum inflammatory factors and peripheral blood lymphocyte subsets in patients with stroke-associated pneumonia[J].,2019,(12):740-742.[doi:10.13798/j.issn.1009-153X.2019.12.007]
点击复制

卒中相关性肺炎血清炎症因子和外周血淋巴细胞亚群的分析()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年12期
页码:
740-742
栏目:
论著
出版日期:
2019-12-24

文章信息/Info

Title:
Analysis of serum inflammatory factors and peripheral blood lymphocyte subsets in patients with stroke-associated pneumonia
文章编号:
1009-153X（2019）12-0740-03
作者:
李　琳　刘　玮　洪　畋　刘佳妮　葛小金　王　芳
430014，武汉市中心医院老年科（李　琳、刘　玮、洪　畋、刘佳妮、葛小金），神经内科（王　芳）
Author(s):
LI Lin1;  LIU Wei1;  LIU Jia-ni1;  HONG Tian1;  GE Xiao-jin1;  WANG Fang2.
1. Department of Geriatrics, Wuhan Municipal Central Hospital, Wuhan, 430014 China; 2. Department of Neurology, Wuhan Municipal Central Hospital, Wuhan 430014, China
关键词:
卒中相关性肺炎; 淋巴细胞; 炎症因子; 外周血
Keywords:
Stroke-associated pneumonia;  Lymphocyte;  Inflammatory factors;  Peripheral blood
分类号:
R 743.3
DOI:
10.13798/j.issn.1009-153X.2019.12.007
文献标志码:
A
摘要:
目的 探讨卒中相关性肺炎（SAP）病人血清炎症因子白细胞介素（IL）-1β、IL-6、IL-4、肿瘤坏死因子-α（TNF-α）的水平变化及其临床意义。方法 选取2016年3月至2017年3月收治的48例SAP，根据A2D2S2L评分分为低危（0~2分，14例）、中危（3~9分，15例）、高危（≥10分，19例）三组。入院后次日清晨取空腹静脉血，应用流式细胞仪测定外周血T淋巴细胞亚群（CD3+、CD4+、CD8+），应用酶联免疫吸附试验法检测血清炎症因子（IL-1β、IL-6、TNF-α、IL-4）。结果 随着危险程度的增高，血清IL-1β、IL-6、IL-4、TNF-α水平均明显增高（P<0.05），外周血CD3+和CD4+细胞百分比显著增高（P<0.05）。低危组CD4+/CD8+显著高于高危组和中危组（P<0.05），而后两组无统计学差异（P>0.05）；三组CD3+/CD8+均无显著差异（P>0.05）。结论 血清炎症因子IL-1β、IL-6、TNF-α、IL-4以及T细胞淋巴亚群变化情况反映SAP病人的A2D2S2L评分，血清IL-1β、IL-4、IL-6、TNF-α与A2D2S2L评分呈正相关，T细胞亚群CD3+、CD4+百分比与A2D2S2L评分呈负相关。
Abstract:
Objective To explore the changes of the levels of serum inflammatory factors and the peripheral blood lymphocyte subsets in patients with stroke-associated pneumonia (SAP). Methods Of 48 patients with SAP treated in our hospital from March, 2016 to March, 2017, 19 with A2D2S2L score≥10 points were in high risk group, 15 with A2D2S2L score 2~9 points in middle risk group and 14 with A2D2S2L score 0~2 points in the low risk group. The serum levels of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and IL-4 and the status of T cell subsets in peripheral blood were determined in the all the patients. Results The serum levels of IL-1β, IL-6, TNF-α and IL-4 were significantly higher in the high risk group than those in the middle risk group (P<0.05), which were significantly higher than those in the low risk group (P<0.05). The serum levels of CD3+ and CD4+ were significantly higher in the low risk group than those in the middle risk group (P<0.05), which were significantly higher than those in the high risk group (P<0.05).The ratio of CD4+ to CD8+ was significantly higher in the low risk group than that in the middle risk group and the high risk group (P<0.05), but there was insignificant difference in the ratio of CD3+ to CD8+ among the three groups (P>0.05). Conclusion It is suggested that the serum levels of Ⅰ L-1β, IL-6,TNF-α and IL-4 may be positively related to A2D2S2L score, and the serum levels of CD3+ and CD4+ and the ratio of CD4+ to CD8+ were negatively related to A2D2S2L score in the patients with SAP.

参考文献/References:

[1] Mc Murray JJ, Ezekowitz JA, Lewis BS, et al. Left ventricu- lar systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial [J]. Circ Heart Fail, 2013, 6(3): 451-460.
[2] 高　媛，高　飒，杨　楠，等. 老年脑卒中病人发生院内感 染的相关因素及应对措施[J]. 中国老年学杂志，2012，32 （8）：1709-1710.
[3] 于芳苹，赵迎春，高丹宇，等. 老年病人脑卒中相关性肺炎 的危险因素分析及防治措施[J].中华老年心脑血管病杂 志，2013，15（10）：1090-1092.
[4] Liao CC, Chang PY, Yeh CC, et al. Outcomes after surgery in patients with previous stroke [J]. Br J Surg, 2014, 101 (12): 1616-1622.
[5] 刘秋红，张杰文，杨景瑞. 老年卒中相关性肺炎病人外周 血T淋巴细胞亚群及血清炎症因子变化的临床分析[J]. 中国实用神经疾病杂志，2016，19（8）：34-35.
[6] Kumar D, Rasool R, Masoodi KZ, et al. Stroke-induced immune depression-a randomized case control study in Kashmiri population of North India [J]. J Stroke Cerebrovasc Dis, 2014, 23(8): 2041-2046.
[7] 门中华. 急性脑卒中合并肺部感染相关因素及对预后的 影响[J]. 中华医院感染学杂志，2012，22（10）：2053-2055.
[8] 邓小虎，陈月华. 血清降钙素原对危重症病人细菌感染的 诊断价值[J]. 放射免疫学杂志，2011，24（6）：705-706.
[9] Liu ZQ, Chu L, Fang JM, et al. Prognostic role of C-reactive protein in prostate cancer: a systematic review and meta- analysis [J]. Asian J Androl, 2014, 16(3): 467-471.
[10] 黄　璟，周　毅. 肿瘤坏死因子α及其抑制剂的研究进展 [J]. 国际口腔医学杂志，2015，42（1）：63-68 .
[11] 李　萍，王　青，李　志. 血清降钙素原、白细胞介素6、C 反应蛋白在感染性疾病中的诊断价值[J]. 检验医学与临 床，2014，11（11）：1553-1555.
[12] Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease [J]. Nat Immunol, 2015, 16(5): 448-457.
[13] Snauwaert S, Verstichel G, Bonte S, et al. In vitro generation of mature, naive antigen-specific CD8(+) T cells with a single T-cell receptor by agonist selection [J]. Leukemia, 2014, 28(4): 830-841.
[14] Sukumar M, Liu J, Ji Y, et al. Inhibiting glycolytic metabo- lism enhances CD8+ T cell memory and antitumor function [J]. J Clin Invest, 2013, 123(10): 4479-4488.
[15] 梁明旋，周桂桃. 免疫球蛋白IgM、IgG、IgA水平检测在肺 炎支原体感染患儿诊断的价值探讨[J]. 医学检验与临 床，2016，27（5）：81-82.

相似文献/References:

[1]曾祥义　彭　涛.外周血淋巴细胞/单核细胞比值与高血压性脑出血血肿扩大的关系[J].中国临床神经外科杂志,2017,(01):7.[doi:10.13798/j.issn.1009-153X.2017.01.003]
　ZENG Xiang-yi,PENG Tao..Relationship of peripheral blood lymphocyte-to-monocyte ratio with hematoma enlargement in patients with hypertensive cerebral hemorrhage[J].,2017,(12):7.[doi:10.13798/j.issn.1009-153X.2017.01.003]
[2]龙强友　漆新伟　王德全.高血压性脑出血外周血炎症标志物与术后30天病死率的关系[J].中国临床神经外科杂志,2017,(05):302.[doi:10.13798/j.issn.1009-153X.2017.05.006]
　LONG Qiang-you,QI Xin-wei,WANG De-quan..Relationship of peripheral blood inflammatory markers with 30-day mortality after surgery in the patients with hypertensive intracerebral hemorrhage[J].,2017,(12):302.[doi:10.13798/j.issn.1009-153X.2017.05.006]

备注/Memo

备注/Memo:
基金项目：武汉市卫计委医学科研项目（WX16D33）（2019-06-27收稿，2019-10-16修回）
更新日期/Last Update: 2019-12-23