[1]曾祥义　彭　涛.外周血淋巴细胞/单核细胞比值与高血压性脑出血血肿扩大的关系[J].中国临床神经外科杂志,2017,(01):7-10.[doi:10.13798/j.issn.1009-153X.2017.01.003]
　ZENG Xiang-yi,PENG Tao..Relationship of peripheral blood lymphocyte-to-monocyte ratio with hematoma enlargement in patients with hypertensive cerebral hemorrhage[J].,2017,(01):7-10.[doi:10.13798/j.issn.1009-153X.2017.01.003]
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外周血淋巴细胞/单核细胞比值与高血压性脑出血血肿扩大的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年01期
页码:
7-10
栏目:
论著
出版日期:
2017-01-18

文章信息/Info

Title:
Relationship of peripheral blood lymphocyte-to-monocyte ratio with hematoma enlargement in patients with hypertensive cerebral hemorrhage
文章编号:
1009-153X（2017）01-0007-04
作者:
曾祥义　彭　涛
611930 四川，彭州市人民医院神经外科
Author(s):
ZENG Xiang-yi;  PENG Tao.
Department of Neurosurgery, People’s Hospital of Pengzhou City, Pengzhou 611930, China
关键词:
高血压性脑出血; 血肿扩大; 外周血; 淋巴细胞; 单核细胞; 比值
Keywords:
Hypertensive cerebral hemorrhage;  Hematoma enlargement;  Lymphocyte-to-monocyte ratio;  Relationship
分类号:
R 743.34
DOI:
10.13798/j.issn.1009-153X.2017.01.003
文献标志码:
A
摘要:
目的 探讨外周血淋巴细胞/单核细胞比值（LMR）与高血压性脑出血血肿扩大的关系。方法 回顾性分析2013~2015年收治的175例高血压性脑出血的临床资料。入院48 h内复查CT示血肿体积较前增加>6 ml或血肿体积较前增加30%以上为血肿扩大。结果 175例中，发生血肿扩大62例（血肿扩大组），未发生血肿扩大113例（血肿未扩大组）。血肿扩大组初始血肿体积、入院时舒张压、入院时收缩压、INR、APTT均明显高于血肿未扩大组（P<0.05），而LMR和入院时GCS评分则明显低于血肿未扩大组（P<0.05）。受试者工作特征曲线分析表明单核细胞计数、LMR、初始血肿体积、入院时GCS评分、入院时收缩压预测血肿扩大的临界值分别为0.55×109/L、1.62、28.41 ml、11分、195 mmHg。多因素Logistic回归分析显示初始血肿体积≥28.41ml[比值比（OR）=3.78，95%可信区间（CI）为1.009~9.164；P=0.003）、LMR<1.62（OR=0.283，95% CI为0.119~0.674；P=0.004）、入院时GCS评分<11分（OR=0.249，95% CI为0.097~0.641；P=0.004）是血肿扩大的独立危险因素。结论 高血压性脑出血血肿扩大与LMR水平有关。
Abstract:
Objective To study the relationship of hematoma enlargement with the peripheral blood lymphocyte-to-monocyte ratio (LMR) in patients with hypertensive cerebral hemorrhage (HCH). Methods The clinical data of 175 patients with HCH treated in our hospital from 2013 to 2015 were analyzed retrospectively. Of 175 patients with HCH, 62 had hematoma enlargement (observed group) and 113 (control group) did not according to the diagnostic criteria of enlarged hematomas (the volume of hematoma increased over 6 ml or 30% compared with that on admission to hospital). Results The volume of primary hematoma, systolic blood pressure (SBP), diastolic blood pressure (DBP), international normalized ratio (INR), and activated partial thromboplastin time (APTT) were significantly higher, while the peripheral blood LMR and GCS were significantly lower in observed group than those in control group on admission to hospital (P<0.05). Receiver operating characteristic curve indicated that the cutting-off point of prediction for hematoma expansion of monocyte count, PLM, primary hematoma volume, GCS, and SBP were 0.55×10 9/L, 1.62, 28.41 ml, 11 points, and 195 mmHg, respectively. Multivariate analysis showed that volume of primary hematoma ≥28.41 ml (OR=3.78; 95% CI 1.009~9.164, P=0.003), LMR<1.62 (OR=0.283; 95% CI 0.119~0.674, P=0.004), and GCS<11 points (OR=0.249; 95% CI 0.097~0.641, P=0.004) were risk independent factors for hematoma expansion in patients with HCH. Conclusion The peripheral blood LMR is associated significantly with hematoma enlargement in the patients with HCH.

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备注/Memo

备注/Memo:
通讯作者：曾祥义，E-mail：3353223429@qq.com
更新日期/Last Update: 2016-10-28