[1]黄昌恒 于耀宇 姚自同.急性缺血性脑卒中机械取栓术中应用替罗非班效果的Meta分析[J].中国临床神经外科杂志,2019,(09):527-530.[doi:10.13798/j.issn.1009-153X.2019.09.005]
 HUANG Chang-heng,YU Yao-yu,YAO Zi-tong.Meta-analysis of impact of tirofiban on clinical effect of mechanical thrombectomy on acute ischemic stroke[J].,2019,(09):527-530.[doi:10.13798/j.issn.1009-153X.2019.09.005]
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急性缺血性脑卒中机械取栓术中应用替罗非班效果的Meta分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年09期
页码:
527-530
栏目:
论著
出版日期:
2019-09-20

文章信息/Info

Title:
Meta-analysis of impact of tirofiban on clinical effect of mechanical thrombectomy on acute ischemic stroke
文章编号:
1009-153X(2019)09-0527-04
作者:
黄昌恒 于耀宇 姚自同
300162 天津,武警特色医学中心神经外科(黄昌恒、于耀宇、姚自同)
Author(s):
HUANG Chang-heng YU Yao-yu YAO Zi-tong
Department of Neurosurgery, Characteristic Medical Center, People’s Armed Police Force; Tianjin 300162, China
关键词:
急性缺血性脑卒中替罗非班机械取栓术Meta分析安全性疗效
Keywords:
Acute ischemic stroke Tirofiban Mechanical thrombectomy Meta analysis
分类号:
R 743.3; R 815.2
DOI:
10.13798/j.issn.1009-153X.2019.09.005
文献标志码:
A
摘要:
目的 系统评价急性缺血性脑卒中机械取栓术中应用替罗非班的安全性及疗效。方法 计算机检索中国知网、PubMed、Embase、Cochrane等数据库,检索急性缺血性脑卒中取栓术中机械使用替罗非班的随机对照试验,试验组机械取栓术中应用替罗非班,对照组术中不应用替罗非班。结局指标为治疗后血管再通率、出血率、3个月预后。采用ReVMan5.3软件进行Meta分析。结果 纳入的6篇文献中,3篇为英文,3篇中文,共计642例,试验组266例,对照组376例。Meta分析结果显示,两组血管再通率、出血风险以及3个月预后良好率均无统计学差异(P>0.05)。结论 急性缺血性脑卒中取栓术中应用替罗非班并不能显著提升血管再通率,但也未明显增加出血风险,对3个月预后也无显著影响,因此,不建议急性缺血性脑卒中取机械栓术中常规使用替罗非班。
Abstract:
Objective To investigate the safety of tirofiban and its effects on the patients with acute ischemic stroke udergoing mechanical thrombectomy. Methods The database CNKI, PubMed, Embase, and Cochrane were searched for the randomized controlled trials of effects of tirofiban on the patients with acute ischemic stroke undergoing mechanical thrombectomy. Meta-analysis of the vascular recanalization rate, bleeding rate and prognosis 3 months after the treatment was performed by ReVMan5.3 statistical software. Results A total of 6 studies were included and 376 patients were enrolled. Meta-analysis showed that there was insignificant effects of tirofiban on the revascularization rate, bleeding rate and prognosis 3 months after the treatment in the patients with acute ischemic stroke undergoing mechanical thrombectomy. Conclusion It is suggested that it is unnecessary for the patients with acute ischemic stroke undergoing mechanical thrombectomy to be treated by tirofiban because tirofiban does not enhanced the cerebral hemorrhage, but also it is not helpful to the improvement of the patients’ prognosis.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者:于耀宇,E-mail:yuyaoyu666@aliyun.com
更新日期/Last Update: 2019-09-20