[1]王 栋 白雪蕾 吴环立 李琳坤 酒晓盈 赵海洋 汪仲伟.出血性脑卒中病人血浆和脑脊液β-内啡肽、GnRH、NO、CGRP的变化及意义[J].中国临床神经外科杂志,2019,(11):669-671.[doi:10.13798/j.issn.1009-153X.2019.11.010]
 WANG Dong,BAI Xue-lei,WU Huan-li,et al.Changes in CSF and plasma levels of β-endorphin, GnRH, NO and CGRP and their meanings in patients with hemorrhagic stroke[J].,2019,(11):669-671.[doi:10.13798/j.issn.1009-153X.2019.11.010]
点击复制

出血性脑卒中病人血浆和脑脊液β-内啡肽、GnRH、NO、CGRP的变化及意义()
分享到:

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年11期
页码:
669-671
栏目:
论著
出版日期:
2019-11-25

文章信息/Info

Title:
Changes in CSF and plasma levels of β-endorphin, GnRH, NO and CGRP and their meanings in patients with hemorrhagic stroke
文章编号:
1009-153X(2019)11-0669-03
作者:
王 栋 白雪蕾 吴环立 李琳坤 酒晓盈 赵海洋 汪仲伟
473012 河南,南阳市第二人民医院神经外科(王 栋、白雪蕾、吴环立、李琳坤、酒晓盈、赵海洋、汪仲伟)
Author(s):
WANG Dong BAI Xue-lei WU Huan-li Li Lin-kun JIU Xiao-ying ZHAO Hai-yang WANG Zhong-wei.
Department of Neurosurgery, Nanyang Second General People`s Hospital, Nanyang 473012, China
关键词:
出血性脑卒中高血压性脑出血蛛网膜下腔出血β-内啡肽GnRHNOCGRP
Keywords:
Hemorrhagic stroke Hypertensive cerebral hemorrhage Subarachnoid hemorrhage β-endorphin GnRH NO CGRP
分类号:
R 743.34
DOI:
10.13798/j.issn.1009-153X.2019.11.010
文献标志码:
A
摘要:
目的 探讨出血性脑卒中病人血浆和脑脊液β-内啡肽、促性腺激素释放激素(GnRH)、一氧化氮(NO)、降钙素基因相关肽(CGRP)的变化及意义。方法 选取2017年6月至2018年12月收治的高血压性脑出血(HICH)80例为HICH组,自发性蛛网膜下腔出血(SAH)52例为SAH组,以无神经系统疾病40例为对照组。检测血浆和脑脊液β-内啡肽、GnRH、CGRP、NO水平。结果 入院时,HICH组和SAH组血浆和脑脊液β-内啡肽、GnRH水平明显增高(P<0.05),而血浆和脑脊液NO、CGRP水平明显降低(P<0.05)。入院后1、3、7、14、30 d,HICH组和SAH组血浆和脑脊液β-内啡肽、GnRH水平逐渐下降(P<0.05)。入院后1、3、7 d,HICH组、SAH组血浆和脑脊液NO、CGRP水平逐渐下降(P<0.05),入院后14、30 d明显上升(P<0.05)。结论 β-内啡肽、GnRH、NO、CGRP参与HICH及SAH病人下丘脑应激反应,以SAH更明显。
Abstract:
Objective To investigate the changes in the plasma and cerebrospinal fluid (CSF) levels of β-endorphin, gonadotropin-releasing hormone (GnRH), nitric oxide (NO), calcitonin gene-related peptide (CGRP) and their meanings in the patients with hemorrhagic stroke. Methods The plasma and CFS levels of β-endorphin, GnRH, CGRP and NO were detected by radioimmunoassay in 46 patients with hypertensive cerebral hemorrhage (HCH), 52 patients with subarachnoid hemorrhage (SAH) and 40 subjects (control group) without neurological system diseases 1, 3, 7, 14 and 30 days after the admission to hospital. Results The plasma and CSF levels of β-endorphin and GnRH were significantly higher in SAH group than those in the CHC group (P<0.05), which were significantly higher than those in the control group (P<0.05) 1, 3, 7, 14 and 30 days after the admission to hospital. The plasma and CFS levels of NO and CGRP were significantly lower in SAH group than those in the CHC group (P<0.05), which were significantly lower than those in the control group (P<0.05). The plasma and CFS levels of β-endorphin and GnRH gradually decreased with the prolongation of time after the admission to hospital in SAH and CHC groups. The plasma and CSF levels of NO and CGRP in the CHC and SAH groups decreased gradually with prolongation of time within 7 days after the admission to hospital, and then increased significantly 14 and 30 days after the admission to hospital. Conclusion β-endorphin, GnRH, NO and CGRP are involved in hypothalamic stress response in the patients with CHC or SAH, especially in the patients with SAH.

参考文献/References:

[1] 刘 舒,刘桂玲,刘春琴,等. 唐山市脑血管病发病时间与 季节规律的研究[J]. 中国医药,2016,11(7):1004-1007. [2] 杨雪梅. 小剂量氯胺酮联合舒芬太尼对老年食管癌病人 疼痛评分及血浆β-内啡肽水平的影响[J]. 中国老年学杂 志,2016,36(14):3476-3477. [3] Liang YF, Song QH, Jiao Y, et al. Cerebral micro-bleeds and the safety of anticoagulation in ischemic stroke patients: a systematic review and meta-analysis [J]. Clin Neuropharmac, 2018, 41(6): 202-209. [4] Ninomiya K, Fukasawa M, Kawakami Y, et al. Nontraumatic convexal subarachnoid hemorrhage accompanied by sylvian hematoma [J]. Am J Forensic Med Pathol, 2018, 39: 54-55. [5] 沈和平,王耿焕,张晓玲,等. 蛛网膜下腔出血病人脑血流 动力学改变与认知功能障碍的相关性分析[J]. 中华物理 医学与康复杂志,2017,39(1):59-61. (下转第674页) (上接第671页) [6] 徐占义,张亚召,赵旺淼,等. 尼莫地平对高血压脑出血治 疗的研究[J]. 检验医学与临床,2017,14(Z1):289-290. [7] 张长福,谭占国,袁 波,等. 基底节区高血压性脑出血的 临床治疗经验[J]. 中华神经外科杂志,2017,33(12): 1266-1267. [8] 李会兵,姚 娟. 高龄高血压小脑出血并脑积水病人手术 疗效分析[J]. 中国实用神经疾病杂志,2017,20(24):64- 66. [9] 李 雪,郭 俊. 内皮素多态性与动脉瘤性蛛网膜下腔出 血后再出血关系研究[J]. 脑与神经疾病杂志,2018,26 (10):620-623. [10] 刘  川. 瑞舒伐他汀对急性脑梗死病人血hsCRP及NO 水平的影响[J]. 北华大学学报(自然科学版),2015,16 (1):75-78. [11] 朴永军,付素云,王 垚,等. 扩血管药物治疗高血压脑出 血的临床效果分析[J]. 中国临床医生杂志,2017,45 (11):50-52. [12] Pasi M, Charidimou A, Boulouis G, et al. Mixed-location cerebral hemorrhage/microbleeds [J]. Neurology, 2018, 90 (2): e119-e126. [13] Al-Kholy S, Kenawi M, Battah A, et al. Inflammatory mark- ers and cerebral vasospasm after aneurysmal subarachnoid hemorrhage [J]. Res Opinion Anesth Intensive Care, 2018, 5 (2): 127-133. [14] 邵正凯,刘 爽,王雪峰,等. 一氧化氮/环磷酸鸟苷信号 与蛛网膜下腔出血后脑血管痉挛相关机制的研究进展 [J]. 中国脑血管病杂志,2016,13(3):165-168. [15] 王玉社,王 勇,陈 航,等. 蛛网膜下腔出血病人Hunt- Hess分级与血清脑钠肽的关系[J]. 中华实验外科杂志, 2016,33(9):2129-2131. [16] 来海鸥,刘永宏,胡新永,等. 脑血管结合 ESRS 对 NCE 病人再发的评估价值[J]. 湖南师范大学学报(医学版), 2016,13(4):16-18,19. [17] 韩喜梅,姚刚,满玉红,等. 都梁软胶囊对偏头痛模型大鼠 中脑CGRP及CCK 表达的影响[J]. 重庆医学,2016,45 (27):3760-3762.

相似文献/References:

[1]孙其凯 李珍珠 曹智洁 高 强 王清波 陈 正 耿 鑫 李泽福.3D打印模型引导下经颞部穿刺引流术治疗颅内血肿[J].中国临床神经外科杂志,2016,(10):586.[doi:10.13798/j.issn.1009-153X.2016.10.004]
 SUN Qi-kai,LI Zhen-zhu,CAO Zhi-jie,et al.Treatment of hypertensive cerebral hemorrhage by the minimally invasive puncture via temporal region under the guidance of 3D printing model[J].,2016,(11):586.[doi:10.13798/j.issn.1009-153X.2016.10.004]
[2]任允平.高血压性基底节区出血破入脑室的治疗体会[J].中国临床神经外科杂志,2016,(10):634.[doi:10.13798/j.issn.1009-153X.2016.10.025]
[3]何明亮,易铭佳,何永通,等.DTI技术在穿刺引流术治疗高血压性基底节区出血疗效评估中的价值[J].中国临床神经外科杂志,2016,(11):682.[doi:10.13798/j.issn.1009-153X.2016.11.010]
 HE Ming-liang,CHEN Rong-hao,CHEN Yin-yan,et al.Clinic effects of minimally invasive techniques on conscious patients with hypertensive basal ganglia hemorrhage and evaluation of the effects[J].,2016,(11):682.[doi:10.13798/j.issn.1009-153X.2016.11.010]
[4]石 浩,樊启涛,袁俊峰,等.小骨窗侧裂入路显微手术治疗高血压性基底节区出血的临床体会[J].中国临床神经外科杂志,2016,(11):715.[doi:10.13798/j.issn.1009-153X.2016.11.024]
[5]白宗旭,师 蔚,姜海涛.高血压性脑出血的个体化手术治疗[J].中国临床神经外科杂志,2016,(11):717.[doi:10.13798/j.issn.1009-153X.2016.11.025]
[6]张 淇,李 辉,方开萱.个体化手术治疗对不同部位高血压性脑出血近期预后的影响[J].中国临床神经外科杂志,2016,(12):762.[doi:10.13798/j.issn.1009-153X.2016.12.010]
 ZHANG Qi,LI Hui,FANG Kai-xuan.Effects of individualized surgical plan on recent prognoses in patients with hypertensive intracerebral hemorrhage[J].,2016,(11):762.[doi:10.13798/j.issn.1009-153X.2016.12.010]
[7]吴 亮,宋子木,夏鹤春,等.垂体脓肿的临床特点及经鼻蝶显微手术治疗[J].中国临床神经外科杂志,2016,(12):771.[doi:10.13798/j.issn.1009-153X.2016.12.013]
[8]李红闪,朱海涛,史彦芳,等.经侧裂-岛叶入路小骨窗显微手术治疗高血压性基底节区出血[J].中国临床神经外科杂志,2016,(12):777.[doi:10.13798/j.issn.1009-153X.2016.12.016]
[9]梁观钦,蔡厚洪,吴 举.多靶点软通道穿刺术治疗高血压性脑内巨型血肿[J].中国临床神经外科杂志,2016,(12):787.[doi:10.13798/j.issn.1009-153X.2016.12.021]
[10]曾祥义 彭 涛.外周血淋巴细胞/单核细胞比值与高血压性脑出血血肿扩大的关系[J].中国临床神经外科杂志,2017,(01):7.[doi:10.13798/j.issn.1009-153X.2017.01.003]
 ZENG Xiang-yi,PENG Tao..Relationship of peripheral blood lymphocyte-to-monocyte ratio with hematoma enlargement in patients with hypertensive cerebral hemorrhage[J].,2017,(11):7.[doi:10.13798/j.issn.1009-153X.2017.01.003]

备注/Memo

备注/Memo:
基金项目:河南省医学科技攻关计划(2018020983)(2019-07-05收稿,2019-09-09修回)
更新日期/Last Update: 2019-11-20