[1]詹增钦 王 涛 许 川 徐国政 祝永红.大型脑动静脉畸形的伽玛刀体积分割治疗[J].中国临床神经外科杂志,2021,26(06):401-405.[doi:10.13798/j.issn.1009-153X.2021.06.001]
 ZHAN Zeng-qin,WANG Tao,XU Chuan,et al.Volume-staged gamma knife radiosurgery for large cerebral arteriovenous malformations (report of 13 cases)[J].,2021,26(06):401-405.[doi:10.13798/j.issn.1009-153X.2021.06.001]
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大型脑动静脉畸形的伽玛刀体积分割治疗()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年06期
页码:
401-405
栏目:
论著
出版日期:
2021-06-25

文章信息/Info

Title:
Volume-staged gamma knife radiosurgery for large cerebral arteriovenous malformations (report of 13 cases)
文章编号:
1009-153X(2021)06-0401-05
作者:
詹增钦 王 涛 许 川 徐国政 祝永红
作者单位:510000 广州,武警广东省总队医院肿瘤中心(詹增钦);430070 武汉,中国人民解放军中部战区总医院神经外科(王 涛、许 川、徐国政、祝永红)
Author(s):
ZHAN Zeng-qin1 WANG Tao2 XU Chuan2 XU Guo-zheng2 ZHU You-hong2.
1. Department of Tumor Medical Center, Guangdong Armed Police Corps Hospital, Guangzhou 510000, China; 2. Department of Neurosurgery, General Hospital of Central Theater Command, PLA, Wuhan 430070, China
关键词:
脑动静脉畸形伽玛刀体积分割治疗立体定向放射外科
Keywords:
Large cerebral arteriovenous malformations Volume-staged gamma knife radiosurgery Stereotactic radiosurgery
分类号:
R 743.4; R 815.2
DOI:
10.13798/j.issn.1009-153X.2021.06.001
文献标志码:
A
摘要:
目的 探讨伽玛刀体积分割治疗大型(体积>10 cm3)脑动静脉畸形(AVM)的临床疗效。方法 回顾性分析 2007~2017年收治的13例大小脑AVM的临床资料,均采用伽玛刀体积分割治疗,时间间隔3~18个月,治疗的AVM总体积平均为18.2 cm3(13.5~52 cm3),首次治疗的体积平均为14.1 cm3(8~23 cm3);边缘剂量平均为16.6 Gy(14~20 Gy)。13例随访24~92个月,平均为43.2个月。结果 末次随访影像显示,6例血管巢闭塞,4例病灶体积减小>75%,3例病灶缩小<50%。8例癫痫中,6例缓解或改善。1例治疗后7个月出现脑出血,1例治疗后6个月因脑放射性副反应出现肢体感觉运动障碍。结论 伽玛刀体积分割治疗大型脑AVM是一种安全、有效的方法,大多数临床症状可明显改善。
Abstract:
Objective To explore the clinical efficacy of volume-staged gamma knife radiosurgery for the patients with large (volume, >10 cm3) brain arteriovenous malformations (AVMs). Methods The clinical data of 13 patients with large brain AVM who underwent volume-staged gamma knife radiosurgery from 2007 to 2017 were analyzed retrospectively. The interval time between the first treatment and the second treatment ranged from 3 months to 18 months. The total volume of AVM ranged from 13.5 cm3 to 52 cm3, with an average of 18.2 cm3. The volume of the first treatment ranged from 8 to 23 cm3, with an average of 14.1 cm3. Marginal dose ranged from 14 Gy to 20 Gy, with an average of 16.6 Gy. The follow-up ranged from 24 months to 92 months, with an average of 43.2 months. Results The last follow-up images showed that the obliteration of AVM was achieved in 6 patients, and the lesion volume reduced by >75% in 4 and <50% in 3. Of 8 patients with preopertive epilepsy, 6 patients were relieved or improved. One patient suffered from cerebral hemorrhage 7 months after the treatment, and 1 patient suffered from limb sensorimotor dysfunction due to brain radiation side effects 6 months after the treatment. Conclusions Volume-staged gamma knife radiosurgery is a safe and effective method for the treatment of large brain AVMs, and most clinical symptoms can be significantly improved.

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备注/Memo

备注/Memo:
共同第一作者:詹增钦、王 涛
通讯作者:许 川,E-mai:569683014@qq.com
更新日期/Last Update: 2021-06-25