[1]张少杰,白三莉,刘洋,等.颅内动脉瘤Enterprise支架辅助弹簧圈栓塞术后的血流动力学变化：基于计算流体力学分析[J].中国临床神经外科杂志,2022,27(01):1-5.[doi:10.13798/j.issn.1009-153X.2022.01.001]
　ZHANG Shao-jie,BAI San-li,LIU Yang,et al.Hemodynamic changes of intracranial aneurysms after Enterprise stent-assisted coil embolization: an analysis using computational fluid dynamics[J].,2022,27(01):1-5.[doi:10.13798/j.issn.1009-153X.2022.01.001]
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颅内动脉瘤Enterprise支架辅助弹簧圈栓塞术后的血流动力学变化：基于计算流体力学分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年01期
页码:
1-5
栏目:
论著
出版日期:
2022-01-15

文章信息/Info

Title:
Hemodynamic changes of intracranial aneurysms after Enterprise stent-assisted coil embolization: an analysis using computational fluid dynamics
文章编号:
1009-153X（2022）01-0001-05
作者:
张少杰;  白三莉;  刘洋;  赵曰圆;  杨铭;  潘力;  马廉亭
510515 广州，南方医科大学第一临床医学院（张少杰、潘力）；430065 武汉，武汉科技大学医学院（白三莉、刘洋）；430070 武汉，中国人民解放军中部战区总医院神经外科（张少杰、白三莉、刘洋、赵曰圆、杨铭、潘力、马廉亭）
Author(s):
ZHANG Shao-jie1; 3;  BAI San-li2; 3;  LIU Yang2; 3;  ZHAO Yue-yuan3;  YANG Ming3;  PAN Li1; 3;  MA Lian-ting3.
1. The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; 2. Medical College, Wuhan University of Science and Technology,Wuhan 430065, China; 3. Department of Neurosurgery, General Hospital of Central Theater Command, PLA, Wuhan 430070, China
关键词:
颅内动脉瘤; 血管内栓塞; Enterprise支架; 弹簧圈; 血流动力学; 计算流体力学分析
Keywords:
Intracranial aneurysms;  Endovascular treatment;  Enterprise stent;  Coil;  Hemodynamics;  Computational fluid dynamics
分类号:
R 743.9; R 815.2
DOI:
10.13798/j.issn.1009-153X.2022.01.001
文献标志码:
A
摘要:
目的探讨颅内动脉瘤Enterprise支架辅助弹簧圈栓塞后瘤腔和载瘤动脉的血流动力学改变。方法回顾性分析2021年3~8月Enterprise支架辅助弹簧圈栓塞治疗的24例颅内动脉瘤的临床资料。收集术前、术后即刻动脉瘤瘤腔和载瘤动脉处DSA数据的DICOM格式，导入OpenFOAM软件，应用计算流体力学数值模拟技术进行血流动力学分析，参数包括壁面剪切力（WSS）、均一化WSS（NWSS）、WSS分布梯度（WSSG）、流线方向WSSG（SWSSG）、归一化压力（NP）、剪切力震荡指数（OSI）。结果24例（24个动脉瘤）应用24枚Enterprise支架，术后即刻造影显示Raymond分级Ⅰ级18例，Ⅱ级6例。栓塞后WSS、NWSS、NWSS最小值、WSSG、WSSG最小值均明显升高（P<0.05），WSSG最大值明显降低（P<0.05）。结论Enterprise支架辅助弹簧圈栓塞治疗明显改变颅内动脉瘤的血流动力学，使载瘤动脉被重建、血流被重构，瘤腔内涡流减少或消失，血流形式由复杂转向简单。这些作用有助于瘤腔内血栓形成。
Abstract:
Objective To investigate the hemodynamic changes of the intracranial aneurysms after Enterprise stent-assisted coil embolization. Methods The clinical data of 24 patients with intracranial aneurysm who received Enterprise stent-assisted coil embolization from March to August 2021 were retrospectively analyzed. The DSA data of the aneurysmal sacs and parent arteries before and immediately after the embolization were put into the OpenFOAM software to analyze the hemodynamics using computational fluid dynamics technique and the hemodynamic parameters including wall shear stress (WSS), normalized WSS (NWSS), WSS gradient (WSSG), streamwise WSSG (SWSSG), normalized pressure (NP) and oscillatory shear index (OSI) were calculated. Results Twenty-four Enterprise stents were used in these 24 patients. Immediate postoperative angiography showed that Raymond grade Ⅰ was achieved in 18 patients and grade Ⅱ in 6. After the embolization, the WSS, the NWSS, the minimum value of NWSS, the WSSG and the minimum value of WSSG were significantly increased (P<0.05), and the maximum value of WSSG was significantly decreased (P<0.05). Conclusions Enterprise stent-assisted coil embolization significantly modifies the hemodynamic patterns of intracranial aneurysms, which help promote the thrombosis formation in the aneurysmal sacs. After embolization, both the parent artery and the blood flow of aneurysmal sac are reconstructed, the vortex of aneurysmal sac is reduced or disappeared and the blood flow patterns change from complex to simple.

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备注/Memo

备注/Memo:
通讯作者：潘力，E-mail：plainfat@163. com
更新日期/Last Update: 2022-01-18