[1]呼铁民　褚会松　田　甜　王昆鹏　杨国军　杨立军　王维兴.脑胶质瘤ADAM17与EGFR的表达及临床意义[J].中国临床神经外科杂志,2017,(08):557-559.[doi:10.13798/j.issn.1009-153X.2017.08.012]
　HU Tie-min,CHU Hui-song,TIAN Tian,et al.Expressions of ADAM17 and EGFR in gliomas tissues and their clinical meanings[J].,2017,(08):557-559.[doi:10.13798/j.issn.1009-153X.2017.08.012]
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脑胶质瘤ADAM17与EGFR的表达及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年08期
页码:
557-559
栏目:
论著
出版日期:
2017-08-25

文章信息/Info

Title:
Expressions of ADAM17 and EGFR in gliomas tissues and their clinical meanings
文章编号:
1009-153X（2017）08-0557-03
作者:
呼铁民　褚会松　田　甜　王昆鹏　杨国军　杨立军　王维兴
067000 河北承德，承德医学院附属医院神经外科
Author(s):
HU Tie-min;  CHU Hui-song;  TIAN Tian;  WANG Kun-peng;  YANG Guo-jun;  YANG Li-jun;  WANG Wei-xing.
Department of Neurosurgery, Affiliated Hospital, Chengde Medical College, Chengde 067000, China
关键词:
脑胶质瘤; 解聚素-金属蛋白酶17; 表皮生长因子受体; 基因表达
Keywords:
Gliomas;  Adisintegrin and metalloproteinase 17;  Epidermal growth factor receptor;  Expression;  Clinical meaning
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2017.08.012
文献标志码:
A
摘要:
目的 探讨解聚素-金属蛋白酶17（ADAM17）与表皮生长因子受体（EGFR）在脑胶质瘤组织中的表达及临床意义。方法 选择2014年2月至2016年8月手术切除68例新鲜脑胶质瘤标本，其中高级别胶质瘤42例，低级别胶质瘤26例。另选择同期颅脑损伤内减压术获取的正常脑组织标本10例为对照组。采用免疫印迹法和免疫组化染色检测ADAM17和EGFR表达。结果 高级别胶质瘤ADAM17和EGFR表达水平均明显高于低级别胶质瘤（P<0.05），而低级别胶质瘤ADAM17和EGFR表达水平均明显高于对照组（P<0.05）。胶质瘤表达水平呈明显正相关（r=0.444，P<0.001）。结论 随着脑胶质瘤恶性程度的增加，EGFR和ADAM17表达水平明显升高，提示EGFRA、DAM17可作为脑胶质瘤恶性程度的评估指标。
Abstract:
Objective To investigate the expressions of adisintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) in the gliomas tissues and their clinical meanings. Methods The expression levels of ADAM17 and EGFR were determined by western blot and immunohischemical technique in 68 samples of fresh gliomas tissues, of which, 42 were derived from the high-grade gliomas and 26 from the low-grade gliomas, and in 10 samples of normal brain tissues derived from the patients with traumatic brain injury undergoing surgery. The relationship between ADAM17 and EGFR was analyzed. Results The expression level of ADAM17 was significantly higher in high-grade gliomas than low-grade gliomas (P<0.01), of which the expression level of ADAM17 was significantly higher than the normal brain tissues (P<0.01). The EGFR protein was not detected in the normal brain tissues. The expression level of EGFR was significantly higher in high-grade gliomas than low-grade gliomas (P<0.01). The positive expression rate of ADAM17 [95.24% (40/42)] was significantly higher in high-grade gliomas than that [61.54% (16/26)] in low-grade gliomas, of which the positive expression rate of ADAM17 was significantly higher than that [20.00% (2/10)] in the normal brain tissues (P<0.01). The positive expression rate of EGFR was significantly higher in high-grade gliomas than that in low-grade gliomas (P<0.01). The expression of ADAM17 was positively related to the expression of EGFR (P<0.01). Conclusions The expressions of EGFR and ADAM17 rise as the malignant degree of brain glioma increases. It is suggested that the high expression levels of ADAM17 and EGFR are closely related to proliferation of glioma cells.

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更新日期/Last Update: 1900-01-01