[1]谢　飞　陈志远　曾家良　叶勇强.DSA联合血清SICAM-1评估颅内破裂动脉瘤术后脑血管痉挛的效果[J].中国临床神经外科杂志,2017,(09):617-618622.[doi:10.13798/j.issn.1009-153X.2017.09.003]
　XIE Fei CHEN Zhi-yuan ZENG Jia-liang,Ye Yong-qiang.Application of DSA combined with serum SICAM-1 to the evaluation of cerebral vasospasm after SAH due to aneurysmal rupture[J].,2017,(09):617-618622.[doi:10.13798/j.issn.1009-153X.2017.09.003]
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DSA联合血清SICAM-1评估颅内破裂动脉瘤术后脑血管痉挛的效果()

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年09期
页码:
617-618622
栏目:
论著
出版日期:
2017-09-25

文章信息/Info

Title:
Application of DSA combined with serum SICAM-1 to the evaluation of cerebral vasospasm after SAH due to aneurysmal rupture
文章编号:
1009-153X（2017）09-0617-02
作者:
谢　飞　陈志远　曾家良　叶勇强
641300 四川，资阳市第一人民医院神经外科
Author(s):
XIE Fei CHEN Zhi-yuan ZENG Jia-liang;  Ye Yong-qiang
Department of Neurosurgery, The First People’s Hospital of Ziyang City, Ziyang 641300, China
关键词:
动脉瘤性蛛网膜下腔出血; 脑血管痉挛; 数字减影血管造影; 可溶性细胞间黏附分子-1
Keywords:
Intracranial aneurysms;  Subarachnoid hemorrhage;  Digital subtraction angiography;  Soluble intercellular adhesion
分类号:
R 743.9
DOI:
10.13798/j.issn.1009-153X.2017.09.003
文献标志码:
A
摘要:
目的 探讨DSA联合可溶性细胞间黏附分子-1（SICAM-1）评估颅内破裂动脉瘤术后脑血管痉挛（CVS）的效果。方法 选择56例颅内破裂动脉瘤急诊术后病人作为研究对象，DSA测定脑血管直径判断CVS程度，结合Hunt-Hess分级，分析CVS与SICAM-1浓度关系。结果 56例中，30例无CVS，9例轻度CVS，10例中度CVS，7例重度CVS。重度CVS血清SICAM-1最高浓度出现在术后4~5 d，其余3组均出现在术后1~3 d。无CVS、轻度CVS、中度CVS与重度CVS血清SICAM-1浓度分别为（273.47±86.54）、（393.47±79.85）、（532.79±69.7）、（664.64±98.71）ng/ml，随着CVS加重，血清SICAM-1浓度显著增高（P<0.01）。结论 脑动脉瘤破裂出血术后行DSA检查联合血清SICAM-1浓度监测可有效预示疾病进展，实现CVS动态观察，可作为CVS发作、进展的危险性评估指标。
Abstract:
Objective To explore the feasibility of the application of DSA combined with serum soluble intercellular adhesion molecule (SICAM-1) to the evaluation of cerebral vasospasm (CVS) severity after subarachnoid hemorrhage (SAH) caused by the aneurysmal rupture. Methods The diameters of the cerebral blood vessels including the first and second sections of the middle cerebral arteries and anterior cerebral arteries were determined by DSA in 56 patients with ruptured intracranial aneurysms undergoing emergency surgery. The severity of CVS was assessed by DSA outcomes combined with Hunt-Hess grading system. The serum levels of SICAM-1 were determined in all the patients. The relationship of the severity of CVS with the serum levels of SICAM-1 was analyzed. Results Of 26 with postoperative CVS of 56 patients with ruptured aneurysms, 9 suffered from mild CVS, 10 from moderate and 7 severe. From 1 to 10 days after the surgery, the mean serum level of SICAM-1 [ (664.64 ±98.71) ng/ml] was significantly higher in 7 patients with severe CVS than that [ (532.79±69.71) ng/ml] in 10 with moderate CVS (P<0.01), which was significantly higher than that [ (393.47±79.51) ng/ml] in 9 with mild CVS (P<0.01), which was significantly higher than that [ (273.47±86.54) ng/ml] in 30 without CVS (P<0.01). Conclusion The serum level of SICAM-1 was positively related to the severity of CVS in the patients with SAH due to ruptured intracranial aneurysms undergoing the surgery. It is suggested that the serum level of SICAM-1 may serve as an index of CVS severity.

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备注/Memo

备注/Memo:
基金项目：四川省卫生厅科研课题（130505） 作者单位：641300 四川，资阳市第一人民医院神经外科（谢　飞、陈志远、曾家良、叶勇强）
更新日期/Last Update: 1900-01-01