[1]郭　松　任志伟　胡永生等.单纯影像定位与微电极辅助定位在帕金森病手术中的应用[J].中国临床神经外科杂志,2021,26(03):149-152.[doi:10.13798/j.issn.1009-153X.2021.03.002]
　GUO Song,REN Zhi-wei,HU Yong-sheng,et al.Simple imaging-guided versus microelectrode recording-guided deep brain stimulaton for patients with Parkinson’s disease[J].,2021,26(03):149-152.[doi:10.13798/j.issn.1009-153X.2021.03.002]
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单纯影像定位与微电极辅助定位在帕金森病手术中的应用()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年03期
页码:
149-152
栏目:
论著
出版日期:
2021-03-25

文章信息/Info

Title:
Simple imaging-guided versus microelectrode recording-guided deep brain stimulaton for patients with Parkinson’s disease
文章编号:
1009-153X（2021）03-0149-04
作者:
郭　松　任志伟　胡永生等
100053 北京，首都医科大学宣武医院功能神经外科/北京市功能神经外科研究所（郭　松、任志伟、胡永生、庄　平、李建宇）
Author(s):
GUO Song;  REN Zhi-wei;  HU Yong-sheng;  et al
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
关键词:
帕金森病; 丘脑底核; 脑深部电刺激术; 微电极记录; 影像学定位
Keywords:
Parkinson’s disease;  Subthalamic nucleus;  Deep brain stimulation;  Microelectrode recording
分类号:
R 742.5; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2021.03.002
文献标志码:
A
摘要:
目的 比较单纯影像定位与微电极辅助定位（MER）进行丘脑底核脑深部电刺激术（STN-DBS）治疗帕金森病（PD）的疗效。方法 回顾性分析2017年1月至2019年12月STN-DBS治疗的112例PD的临床资料。70例通过单纯影像定位（影像组），42例通过MER辅助定位（MER组）。术前与术后3个月，进行“关”状态下统一帕金森病评定量表（UPDRS）运动部分（Ⅲ）评分评估疗效，症状改善率=（术前评分-术后评分）/术前评分×100%。结果 影像组手术时间[（125±17）min]较MER组[（158±23）min]明显缩短（P<0.05）。两组电极尖端位置、术后3个月刺激参数（电压、频率、脉宽）均无统计学差异（P>0.05）。与术前药物“关”状态基线数据相比，术后3个月药物“关”状态DBS开启时，两组运动功能评分无统计学差异（P>0.05）。影像组运动功能评分改善率（56.3%）、震颤症状改善改善率（79.5%）、僵直症状改善率（57.9%）、运动迟缓评分改善率（44.8%）与MER组（分别为56.4%、75.4%、60.9%、47.6%）均无统计学差异（P>0.05）。两组术后均未发生出血及感染。结论 对于 STN-DBS治疗PD，单纯影像学定位与MER辅助定位技术对脑深部电极埋置位置和运动症状改善无明显差异，但是单纯影像定位技术可以缩短手术时间。
Abstract:
Objective To compare the clinical efficay of simple imaging (SI)-guided versus microelectrode recording (MER)-guided subthalamic nucleus deep brain stimulation (STN-DBS) for the patients with Parkinson’s disease (PD). Methods The clinical data of 112 PD patients who undewent STN-DBS from January 2017 to December 2019 were analyzed retrospectively. Of 112 patients, 70 received SI-guided STN-DBS (SI group) and 42 received MER-Guided STN-DBS (MER group). The clinical efficacy was assessed by unified Parkinson Disease Scale (III) Score before and 3 months after the surgery, with symptom improvement rate as: (preoperative score-postoperative score)/preoperative score×100%. Results The operation time in SI group [(125±17)min] was significantly shorter than that [(158±23)min] in MER group (P<0.05). There was no significant difference in the position of electrode, and stimulating parameters and symptom improvement rate 3 months after the operation between the two groups (P>0.05). There was no psotoperative bleeding and infection in both groups. Conclusions For the PD patients receiving STN-DBS, there were no significant differences in the clinical motor outcomes and positions of electrodes between the two techniques, but the SI positioning technique can shorten the operation time.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：李建宇，E-mail：lijianyu@vip.sohu.com
更新日期/Last Update: 2021-03-25