[1]蒋　伟　郐国虎　刘魏华等.双侧丘脑底核脑深部电刺激术治疗帕金森病的疗效分析[J].中国临床神经外科杂志,2021,26(10):755-757.[doi:10.13798/j.issn.1009-153X.2021.10.004]
　JIANG Wei,KUAI Guo-hu,LIU Wei-hua,et al.Clinical efficacy of bilateral subthalamic nucleus deep brain stimulation for patients with Parkinson’s disease[J].,2021,26(10):755-757.[doi:10.13798/j.issn.1009-153X.2021.10.004]
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双侧丘脑底核脑深部电刺激术治疗帕金森病的疗效分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年10期
页码:
755-757
栏目:
论著
出版日期:
2021-10-25

文章信息/Info

Title:
Clinical efficacy of bilateral subthalamic nucleus deep brain stimulation for patients with Parkinson’s disease
文章编号:
1009-153X（2021）10-0755-03
作者:
蒋　伟　郐国虎　刘魏华等
作者单位：430030 武汉，华中科技大学同济医学院附属同济医院神经外科（蒋　伟、刘魏华、张复弛、舒　凯、杨正明、雷　霆）；430064 武汉，武汉科技大学附属天佑医院神经外科（郐国虎）
Author(s):
JIANG Wei;  KUAI Guo-hu;  LIU Wei-hua;  et al
1. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Chna; 2. Department of Neurosurgery, Tianyou Hospital Affilicated to Wuhan University of Science and Technology, Wuhan 430064, China
关键词:
帕金森病; 脑深部电刺激; 丘脑底核; 疗效
Keywords:
Parkinson’s disease;  Deep brain stimulation;  Subthalamic nucleus;  Clinical efficacy
分类号:
A
DOI:
10.13798/j.issn.1009-153X.2021.10.004
文献标志码:
R 742.5; R 651.1+1
摘要:
目的 探讨双侧丘脑底核脑深部电刺激术（STN-DBS）治疗药物难以控制或副反应难以耐受的帕金森病（PD）的疗效。方法 回顾性分析2015年6月至2019年6月双侧STN-DBS治疗药物难以控制或副反应难以耐受的171例PD的临床资料。术后6个月采用第三版统一帕金森病评分量表（UPDRS-Ⅲ）评分及第二版世界卫生组织生活质量评定量表（WHO-QOL-2）评分评估疗效。结果 术后6个月，UPDRS-Ⅲ评分明显降低（P<0.05），WHO-QOL-2评分明显增高（P<0.05）。术后抗PD药物使用剂量明显降低（P<0.05）。术后发生颅内出血1例（0.58%），切口感染3例（1.75%），排异反应2例（1.17%），癫痫发作1例（0.58%），因设备故障更换脉冲发生器1例（0.58%），体重增加12例（7.01%），构音障碍8例（4.67%），睁眼困难4例（2.34%），智力减退4例（2.34%）。结论 对于药物难以控制及副反应难以耐受的PD病人，双侧STN-DBS治疗PD可显著改善病人症状、提高生活质量及减少口服药物量。
Abstract:
Objective To investigate the clinical efficacy of bilateral subthalamic nucieus deep brain stimulation (STN-DBS) for the Parkinson’s disease (PD) patients associating with drug-uncontrollable symptoms or severe side effects. Methods The clinical data of 171 patients associating with drug-uncontrollable symptoms or severe side effects who underwent bilateral STN-DBS from June 2015 to June 2019 were analyzed retrospectively. Six months after the operation, Unified Parkinson’s Disease Rating Scale version (3.0) (UPDRS-Ⅲ) and World Health Organization Quality-of-Life Scale version (2.0) (WHO-QOL-2) were used to evaluate the clinical efficacy. Results Six months after the operation, the UPDRS-Ⅲ score was significantly reduced (P<0.05), the WHO-QOL-2 score was significantly increased (P<0.05), and the dosages of anti-PD drugs were significantly reduced (P<0.05). Postoperative intracranial hemorrhage occurred in 1 patient (0.58%), incision infection in 3 (1.75%), rejection reaction in 2 (1.17%), seizure in 1 (0.58%), pulse generator replacement due to equipment failure in 1 (0.58%), weight gain in 12 (7.01%), dysarthria in 8 (4.67%), difficulty in opening eyes in 4 (2.34%), and mental retardation in 4 (2.34%). Conclusions For PD patients associating with drug-uncontrollable symptoms or severe side effects, bilateral STN-DBS treatment can significantly improve patients’ symptoms, improve patients’ quality of life, and reduce the dosage of anti-PD drugs.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：舒　凯，E-mail：kshu@tjh.tjmu.edu.cn
更新日期/Last Update: 1900-01-01