[1]朱郭婷　陈思思　黄书岚.血清淀粉样蛋白A与自发性脑出血预后的关系[J].中国临床神经外科杂志,2017,(08):539-541.[doi:10.13798/j.issn.1009-153X.2017.08.005]
　ZHU Guo-ting,CHEN Si-si,HUANG Shu-lan..Relationship of serum level of amyloid protein A with prognoses in patients with acute spontaneous intracerebral hemorrhage[J].,2017,(08):539-541.[doi:10.13798/j.issn.1009-153X.2017.08.005]
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血清淀粉样蛋白A与自发性脑出血预后的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年08期
页码:
539-541
栏目:
论著
出版日期:
2017-08-25

文章信息/Info

Title:
Relationship of serum level of amyloid protein A with prognoses in patients with acute spontaneous intracerebral hemorrhage
文章编号:
1009-153X（2017）08-0539-03
作者:
朱郭婷　陈思思　黄书岚
作者单位：430060 武汉，武汉大学人民医院神经外科（朱郭婷、陈思思、黄书岚）
Author(s):
ZHU Guo-ting ;  CHEN Si-si;  HUANG Shu-lan.
Department of Neurosurgery, Renmin Hospital, Wuhan University, Wuhan 430060, China
关键词:
自发性脑出血; 血清; 淀粉样蛋白A; 预后
Keywords:
Acute intracerebral hemorrhage;  Serum amyloid protein A;  Prognosis
分类号:
R 743.34
DOI:
10.13798/j.issn.1009-153X.2017.08.005
文献标志码:
A
摘要:
目的 探讨血清淀粉样蛋白A（AA）与自发性脑出血病人预后的关系。方法 选取2014年1月至2016年1月接受钻孔引流术治疗的自发性脑出血78例，术前及术后1、3、5、7、14 d动态检测外周血AA水平。术后6个月采用GOS评估预后。结果 78例中，预后良好56例（GOS评估4~5分），预后不良22例（GOS评分1~3分）。血清AA水平术后1 d达到高峰，之后逐渐下降，并于术后7 d逐渐降至正常水平。预后良好组血清AA水平较预后不良组明显降低（P<0.05）。多因素Logistic回归分析显示术后再出血以及术后1 d血清AA水平是自发性脑出血不良预后的独立危险因素。结论 术后1 d血清AA水平升高预示自发性脑出血病人预后不良，术后血清AA水平可作为自发性脑出血病人的预后评估指标。
Abstract:
Objective To investigate the relationship between the level of serum amyloid protein A (SAA) and clinical prognoses in the patients with spontaneous intracerebral hemorrhage (sICH). Methods The levels of SAA before the operation and 1, 3, 5 and 7 days and at discharge from the hospital were determined in 78 patients with sICH receiving drilling for drainage. The relationship between the levels of SAA and prognoses 6 months after the operation was analyzed by univariate and multivariate logistic regression analyses. Results Of 78 patients, 56 had good prognoses and 22 poor according to GOS 6 months after the operation. The levels of SAA,D-Dimer, the rate of low GCS score before the operation, the rate of rebleeding after operation, and the levels of SAA 1, 3, and 5 days after operation were significantly higher in the patients with poor prognoses than those in the patients with good prognoses (P<0.05). The multivariate analysis showed the low GCS score before operation, rebleeding and high level of SAA 1 day after the operation were independent risk factors for poor outcomes (P<0.05). Conclusions It is suggested that the level of SAA 1 day after operation is very helpful to prediction of the prognoses because its high levels is an independent risk factor for the prognoses in the patients with sICH.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：黄书岚，E-mail：donghuyufu@qq.com
更新日期/Last Update: 1900-01-01