[1]范国锋,秦　虎,王增亮,等.血清PCT、IL-6、CRP在颅脑损伤术后颅内感染的早期诊治中的价值[J].中国临床神经外科杂志,2019,(04):207-210.[doi:10.13798/j.issn.1009-153X.2019.04.006]
　FAN Guo-feng,QIN Hu,WANG Zeng-liang,et al.Value of serum PCT、CRP、and IL-6 in diagnosis of postoperative intracranial infection in patients with traumatic brain injury[J].,2019,(04):207-210.[doi:10.13798/j.issn.1009-153X.2019.04.006]
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血清PCT、IL-6、CRP在颅脑损伤术后颅内感染的早期诊治 中的价值()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年04期
页码:
207-210
栏目:
论著
出版日期:
2019-04-27

文章信息/Info

Title:
Value of serum PCT、CRP、and IL-6 in diagnosis of postoperative intracranial infection in patients with traumatic brain injury
文章编号:
1009-153X（2019）02-0207-04
作者:
范国锋; 秦　虎; 王增亮; 高　勇; 汪永新
830054 乌鲁木齐，新疆医科大学第一附属医院神经外科（范国锋、秦　虎、王增亮、高　勇、汪永新）
Author(s):
FAN Guo-feng;  QIN Hu;  WANG Zeng-liang;  GAO Yong;  WANG Yong-xin.
Department of Neurosurgery, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China
关键词:
颅脑损伤; 显微手术; 颅内感染; 降钙素原; C-反映蛋白; 白介素-6
Keywords:
Traumatic brain injury;  Postoperative intracranial infection;  Procalcitonin;  C-reactive protein;  Interleukin-6
分类号:
R 651.1+5; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2019.04.006
文献标志码:
A
摘要:
目的 探讨血清降钙素原（PCT）、白介素-6（IL-6）、C-反应蛋白（CRP）对颅脑损伤术后早期颅内感染的诊断价值。方法 选取2016年1月至2018年1月收治的颅脑损伤术后颅内感染23例作为 感染组，同期颅脑损伤术后未出现颅内感染46例作为对照组。感染组给予万古霉素及美罗培南治疗。术后12 h内采取空腹肘静脉血5 ml，采用双抗体夹心免疫化学发光法半定量快速实验测定血清PCT含量 ，采用全自动免疫透视比浊法测定血清CRP含量，采用全自动免疫化学发光法测定血清IL-6含量。感染组给药第1、3、6、9、12天（五次）清晨空腹采取肘静脉血5 ml检测血清PCT、IL-6、CRP。采用受试 者工作特征（ROC）曲线判断各指标对颅内感染的诊断效能。结果 感染组23例中，12例治愈，6例好转，5例无效或加重；感染控制18例，未控制5例。术后12 h内，感染组血清PCT、CRP、IL-6浓度均明显 高于对照组（P<0.05）。感染控制组血清PCT和CRP浓度显著低于未控制组（P<0.05）。血清PCT、CRP、IL-6判断颅内感染最佳截断值分别为0.51 ng/ml、16.25 mg/ml、32.67 pg/ml，敏感性分别为52.2% 、91.3%、91.3%，特异性分别为82.6%、79.4%、87.0%；三者联合判断颅内感染的敏感性为100.0%，特异性为79.3%。结论 血清PCT、IL-6和CRP均有助于早期诊断颅脑损伤术后颅内感染，三者联合检测对 于诊断颅内感染效果更好。
Abstract:
Objective To investigate the value of serum procalcitonin (PCT), interleukin-6 (IL-6) and C-reactive protein (CRP) levels in the diagnosis of postoperative intracranial infection (PII) in patients with traumatic brain injury (TBI). Methods The clinical data of 69 patients with TBI undergoing the surgery from January, 2016 to January 2018, of whom 23 suffered from PII (infection group) and 46 did not (control group), were analyzed retrspectively. The serum PCT, CRP and IL-6 levels were determined 12 hours after the operation in all the patients and 1, 3, 6, 9 and 14 days after the antibiotic therapy in 23 patients with intracranial infection. Results Of 23 patients with PII, 18 were cured and 5 not. The levels of serum PCT, CRP and IL-6 12 hours after the operation were significantly higher in the infection group than those in the control group (P<0.05). The levels of serum PCT and CRP after the treatment were significantly lower in the patients who were cured than those who were not (P<0.05). The ROC curve showed that the best cut-off values of serum PCT, CRP, and IL-6 to the diagnosis of the PII were 0.51 ng/ml, 16.25 mg/ml and 32.67 pg/ml, respectively. The sensitivity of the serum PCT, CRP and IL-6 level to the diagnosis of PII were 52.2%, 91.3% and 91.3%, respectively. The specificity of the serum PCT, CRP and IL-6 level to the diagnosis of PII were 82.6%, 79.4% and 87.0%, respectively. The sensitivity and specificity of serum PCT, CRP combined with IL-6 to the diagnosis of PII were 100.0% and 79.3%, respectively. Conclusions The levels of serum PCT, CRP and IL-6 are helpful to the diagnosis of PII, and the levels of serum CRP and PCT are of value to the assessment of curative effects on the PII in the patients with TBI.

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备注/Memo

备注/Memo:
（2018-03-12收稿，2018-10-21修回）
更新日期/Last Update: 2019-04-27