[1]刘青云　刘　俊　付　俊　陈　勇　隗世波　王学军.急性颅脑损伤病人血浆H2S和TNF-α相关性分析[J].中国临床神经外科杂志,2017,(06):398-399,402.[doi:10.13798/j.issn.1009-153X.2017.06.010]
　LIU Qing-Yun,LIU Jun,FU Jun,et al.Analysis of correlation of plasma levels of hydrogen sulfide and tumor necrosis factor-α with severity of traumatic brain injury[J].,2017,(06):398-399,402.[doi:10.13798/j.issn.1009-153X.2017.06.010]
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急性颅脑损伤病人血浆H2S和TNF-α相关性分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年06期
页码:
398-399,402
栏目:
论著
出版日期:
2017-06-25

文章信息/Info

Title:
Analysis of correlation of plasma levels of hydrogen sulfide and tumor necrosis factor-α with severity of traumatic brain injury
文章编号:
1009-153X（2017）06-0398-02
作者:
刘青云　刘　俊　付　俊　陈　勇　隗世波　王学军
430050 武汉，武汉科技大学附属汉阳医院重症医学科（刘青云、刘　俊、付　俊、陈　勇、隗世波）；100073 北京，北京电力医院急诊科（王学军）
通讯作者：王学军，E-mail：wangyanyuzhuo@163.com
Author(s):
LIU Qing-Yun1;  LIU Jun1;  FU Jun1;  CHEN Yong1;  KUI Shi-bo1;  WANG Xue-Jun2.
1. Department of Neurosurgery, Affiliated Hanyang Hospital, Wuhan University of Sciences and Technology, Wuhan 430050, China;
2. Department of Emergency, Beijing Electric Power Hospital, Beijing 100073, China
关键词:
颅脑损伤; 硫化氢; 肿瘤坏死因子-α; 血浆
Keywords:
Traumatic brain injury;  Hydrogen sulfide;  Tumor necrosis factor-α;  Plasma level;  Correlation
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2017.06.010
文献标志码:
A
摘要:
目的 探讨急性颅脑损伤病人血浆硫化氢（H2S）与肿瘤坏死因子-α（TNF-α）的相关性。方法 2015年3月至2016年10月收治急性颅脑损伤42例，其中轻型14例，中型13例，重型15例；以同期健康体检者30例作为对照组。采用亚甲基蓝法测定血浆H2S水平，采用双抗体夹心酶联免疫吸附法检测血浆TNF-α的浓度。结果 与对照组比较，颅脑损伤病人血浆H2S水平显著降低（P<0.05），随颅脑损伤程度加重，血浆H2S明显降低（P<0.05）。颅脑损伤血浆TNF-α水平变化与H2S相反。轻型颅脑损伤病人血浆H2S与TNF-α水平无明显相关性（P>0.05）。中型、重型颅脑损伤血浆H2S与TNF-α呈明显负相关（r分别为-0.46、-0.52；P<0.05）。结论 本研究结果提示颅脑损伤后内源性H2S生成减少可能是导致炎症因子生成增加的原因之一。
Abstract:
Objective To explore the correlation of plasma levels of hydrogen sulfide (H2S) and tumor necrosis factor-α (TNF-α) with severity of traumatic brain injury (TBI). Methods The plasma levels of H2S and TNF-α were determined respectively by methylene blue method and double antibody sandwich ELISA in 14 patients with mile TBI, 13 patients with moderate TBI, 15 patients with severe TBI and 30 healthy subjects. Results The plasma level of H2S was significantly lower in the patients with severe TBI than that in the patients with moderate TBI (P<0.05), which was significantly lower than that in the patients with mild TBI (P<0.05), which was significantly lower than that in the healthy subjects (P<0.05). The plasma level of TNF-α was significantly higher in the patients with severe TBI than that in the patients with moderate TBI (P<0.05), which was significantly higher than that in the patients with mild TBI (P<0.05), which was significantly higher than that in the healthy subjects (P<0.05). The plasma TNF-α levels were negatively related to the plasma H2S levels in the patients with moderate or severe TBI (P<0.05). Conclusion It is suggested that the changes in the plasma levels of H2S and TNF-α may play an important role in the pathophysiologic process after TBI.

参考文献/References:

[1] Corrigan F, Mander KA, Leonard AV, et al. Neurogenic inflammation after traumatic brain injury and its potentia- tion of classical inflammation [J]. J Neuroinflam, 2016, 13: 264.
[2] Abdul-Muneer PM, Chandra N, Haorah J. Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury [J]. Mol Neurobiol, 2015, 51(3): 966-979.
[3] Gemici B, Elsheikh W, Feitosa KB, et al. H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreven- tative potential [J]. Nitric Oxide, 2015, 46: 25-31.
[4] Wallace JL, Ianaro A, Flannigan KL, et al. Gaseous media- tors in resolution of inflammation [J]. Semin Immunol, 2015, 27(3): 227-233.
[5] Sha Y, Zmijewski J, Xu Z, et al. HMGB1 develops enhanced proinflammatory activity by binding to cytokines [J]. J Immunol, 2008, 180: 2531-2537.
[6] 郑　扬，廖　锋，杜军保，等. 改良亚甲基蓝法测定血浆 硫化氢[J]. 生理学报，2012，64（6）：681-686.
[7] Zhang X, Bian JS. Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system [J]. Chem Neurosci, 2014, 5(10): 876-83.
[8] Jiang X, Huang Y, Lin W, et al. Protective effects of hydro- gen sulfide in a rat model of traumatic brain injury via acti- vation of mitochondrial adenosine triphosphate-sensitive potassium channels and reduction of oxidative stress [J]. J Surg Res, 2013, 184(2): e27-35.
[9] Alexander JJ, Jacob A, Cunningham P, et al. TNF-α is a key mediator of septic encephalopathy acting through its recep- tor, TNF receptor-1 [J]. Neurochem Int, 2008, 52: 447-456.
[10] Sivarajah A, Collino M, Yasin M, et al. Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R [J]. Shock, 2009, 31(3): 267-274.
[11] Su Y, Fan W, Ma Z, et al. Taurine improves functional and histological outcomes and reduces inflammation in trauma- tic brain injury [J]. Neuroscience, 2014, 266: 56-65.
[12] Yin J, Tu Ch, Zhao J, et al. Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats [J]. Brain Res, 2013, 1491: 188-196.

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备注/Memo

备注/Memo:
基金项目：武汉市卫生计生委医疗卫生科研项目（WX12D04）；武汉市汉阳区科技计划项目（D20121108）
更新日期/Last Update: 2017-06-25