[1]张　伟,刘　永,王为文,等.坦度螺酮治疗癫痫伴焦虑、抑郁效果的系统评价[J].中国临床神经外科杂志,2019,(04):200-203.[doi:10.13798/j.issn.1009-153X.2019.04.004]
　ZHANG Wei,LIU Yong,WANG Wei-wen,et al.Meta analysis of curative effect of tandospirone on epileptic patients with depression and anxiety[J].,2019,(04):200-203.[doi:10.13798/j.issn.1009-153X.2019.04.004]
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坦度螺酮治疗癫痫伴焦虑、抑郁效果的系统评价()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年04期
页码:
200-203
栏目:
论著
出版日期:
2019-04-27

文章信息/Info

Title:
Meta analysis of curative effect of tandospirone on epileptic patients with depression and anxiety
文章编号:
1009-153X（2019）04-0200-04
作者:
张　伟; 刘　永; 王为文; 靳俊功; 孟　强
710038 西安，空军军医大学唐都医院神经外科（张　伟、刘　永、王为文、靳俊功、孟　强）
Author(s):
ZHANG Wei;  LIU Yong;  WANG Wei-wen;  JIN Jun-gong;  MENG Qiang.
Neurosurgery Department, Tangdu Hospital, Air Force Medical University, Xi’an 710038, China
关键词:
癫痫; 焦虑; 抑郁; 坦度螺酮; 系统评价
Keywords:
Tandospirone;  Epilepsy;  Depression;  Anxiety;  Curative effect;  Meta analysis
分类号:
R 742.1
DOI:
10.13798/j.issn.1009-153X.2019.04.004
文献标志码:
A
摘要:
目的 系统评价坦度螺酮治疗癫痫伴焦虑、抑郁的临床效果及安全性。方法 计算机检索PubMed、Cochrane、Science Direct、Embase、维普、万方和中国知网等数据库，检索时间为从建库至 2018年8月，收集坦度螺酮治疗癫痫合并焦虑抑郁的随机对照试验，应用Rev Man 5.3软件进行Meta分析。结果 共纳入6个随机对照试验，包含462例。Meta分析结果显示：坦度螺酮显著降低汉密尔顿焦虑 量表评分（SMD=-1.01；95% CI：-1.91~-0.11；P=0.03），显著降低汉密尔顿抑郁量表评分（SMD=-1.57；95% CI：-2.42~-0.72；P=0.001），显著降低副反应发生率（OR=0.43；95% CI：0.22~0.82； P=0.01），显著增加有效率（OR=3.31；95% CI：1.97~5.56；P<0.001）。结论 坦度螺酮治疗癫痫伴焦虑抑郁具有显著的临床效果及较好的药物安全性。
Abstract:
Objective To assess the clinical efficacy and safety of tandospirone in epileptic patients with depression and anxiety．Methods Randomized controlled trials (RCTs) of treatment of epileptic patients with depression and anxiety by tandospirone were searched from the data bases including Pubmed, Cochrane, ScienceDirect, Embase, CNKI, VIP and Wanfang Database. Meta-analysis of the curative effect of tandospuirone on the epileptic patients with depression and anxiety was conducted with Revman 5.3. Results Six RCTs including 462 epileptic patients with depression and anxiety were derived from the mentioned-above data bases. The meta-analysis showed that the scores of Hamilton Anxiety Scale (SMD=-1.01, 95%CI -1.91~-0.11, P=0.03) and Hamilton depression scale (SMD=-1.57, 95%CI -2.42~-0.72, P=0.0003) and adverse events rate (OR=0.43, 95%CI 0.22~0.82, P=0.01) were significantly lower in tandospirone group than those in control group. The effective rate was significantly higher in tandospirone group than that in control group(OR=3.31, 95%CI 1.97~5.56, P<0.00001). Conclusions The curative effect of tandospirone on the epileptic patients with depression and anxiety and its safety are good.

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备注/Memo

备注/Memo:
（2018-08-28收稿，2018-12-10修回）
更新日期/Last Update: 2019-04-27