[1]王昆鹏,张建党,董孟宁,等.胶质母细胞瘤PPFIBP1的表达及其临床意义[J].中国临床神经外科杂志,2022,27(09):748-750.[doi:10.13798/j.issn.1009-153X.2022.09.009]
 WANG Kun-peng,ZHANG Jian-dang,DONG Meng-ning,et al.Expression of PPFIA-binding protein 1 in glioblastoma and its clinical significancence[J].,2022,27(09):748-750.[doi:10.13798/j.issn.1009-153X.2022.09.009]
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胶质母细胞瘤PPFIBP1的表达及其临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年09期
页码:
748-750
栏目:
论著
出版日期:
2022-09-30

文章信息/Info

Title:
Expression of PPFIA-binding protein 1 in glioblastoma and its clinical significancence
文章编号:
1009-153X(2022)09-0748-03
作者:
王昆鹏张建党董孟宁刘素杰徐广建
473000 河南,南阳市中心医院神经外科(王昆鹏、张建党、董孟宁、刘素杰、徐广建)
Author(s):
WANG Kun-peng ZHANG Jian-dang DONG Meng-ning LIU Su-jie XU Guang-jian
Department of Neurosurgery, Nanyang Central Hospital, Nanyang 473000, China
关键词:
胶质母细胞瘤PPFIA结合蛋白1(PPFIBP1)生存预后基因表达
Keywords:
Glioblastoma PPFIA-binding protein 1 Survival prognosis Gene expression
分类号:
R739.41;Q786
DOI:
10.13798/j.issn.1009-153X.2022.09.009
文献标志码:
A
摘要:
目的 探讨PPFIA结合蛋白1(PPFIBP1)在胶质母细胞瘤中的表达及其与病人生存预后的关系。方法 选取2011年6月至2018年6月手术切除的胶质母细胞瘤116例,另选取颅脑损伤内减压术中切除的非肿瘤脑组织68例为对照,用免疫组化染色法检测PPFIBP1的表达。随访截止2021年6月,记录总生存期和无进展生存期。结果 胶质母细胞瘤组织PPFIBP1高表达率[67.24%(78/116)]明显高于对照组[17.65%(12/68);P<0.05]。多因素Cox回归分析显示,PPFIBP1高表达是胶质母细胞瘤病人总体生存预后和无进展生存预后不良的独立危险因素(P<0.05)。生存曲线分析显示,PPFIBP1高表达组中位总体生存期和中位无进展生存期较低表达组均明显缩短(P<0.05)。结论 PPFIBP1在胶质母细胞瘤中呈高表达,与病人不良生存预后有关。
Abstract:
Objective To investigate the expression of PPFIA binding protein 1 (PPFIBP1) in glioblastoma tissues and its relationship with the survival prognosis of glioblastoma patients. Methods The expression of PPFIBP1 was detected using immunohistochemical staining in glioblastoma tissues obtained from 116 glioblastoma patients who underwent microsurgery from June 2011 to June 2018 and in non-tumor cerebral tissues obtained from 68 patients (control group) with traumatic brain injury who underwent decompression. The glioblastoma patients were followed up to June 2021, and the overall survival (OS) and progression-free survival (PFS) were recorded. Results The high expression rate of PPFIBP1 in the glioblastoma tissues [67.24% (78/116)] was significantly higher than that [17.65% (12/68)] in the control group (P<0.05). Multivariate Cox regrassion analysis showed high expression of PPFIBP1 was an independent risk factor for poor OS and PFS of glioblastoma patients (P<0.05). The survival curve analysis showed that the OS and PFS of glioblastoma patients with high expression of PPFIBP1 were significantly shorter than those of glioblastoma patients with low expression of PPFIBP1 (P<0.05). Conclusions PPFIBP1 is highly expressed in glioblastoma tissues, which is related to the poor survival prognosis of glioblastoma patients.

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备注/Memo

备注/Memo:
(2022-06-22收稿,2022-08-12修回)
通讯作者:张建党,E-mail:wangkunpeng129@163.com
更新日期/Last Update: 2022-10-31