[1]王占福　邢德广　陈爱国　王义宝　王运杰.垂体腺瘤TGF-β1和CTGF的表达及意义[J].中国临床神经外科杂志,2015,(03):155-157.[doi:10.13798/j.issn.1009-153X.2015.03.009]
　WANG Zhan-fu,XING De-guang,Chen Ai-guo,et al.Preliminary study of expressions of TGF-β1 and CTGF in fibrosis pituitary adenomas and their meanings[J].,2015,(03):155-157.[doi:10.13798/j.issn.1009-153X.2015.03.009]
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垂体腺瘤TGF-β1和CTGF的表达及意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年03期
页码:
155-157
栏目:
论著
出版日期:
2015-03-30

文章信息/Info

Title:
Preliminary study of expressions of TGF-β1 and CTGF in fibrosis pituitary adenomas and their meanings
文章编号:
1009-153X（2015）03-0155-03
作者:
王占福　邢德广　陈爱国　王义宝　王运杰
10041，沈阳市第一人民医院神经外科（王占福）；250033济南，山东大学第二医院神经外科（邢德广）；110001沈阳，中国医科大学附属第一医院神经外科（陈爱国、王义宝、王运杰）
通讯作者：王运杰，E-mail：wangyunjie_cmu@sina.com
Author(s):
WANG Zhan-fu1;  XING De-guang2;  Chen Ai-guo3;  WANG Yi-bao3;  WANG Yun-jie3.
1. Department of Neurosurgery, The First People's Hospital of Shenyang City, Shenyang 110041, China; 2. Department of Neurosurgery, The Second Hospital, Shandong University, Ji'nan 250033, China; 3. Department of Neurosurgery, The First Hospital, Chinese Medical University, Shenyang 110001, China
关键词:
垂体腺瘤; 纤维化; 转化生长因子β1; 结缔组织生长因子; 基因表达
Keywords:
Pituitary adenoma;  Fibrosis;  Transforming growth factor;  Connective tissue growth factor;  Expression
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2015.03.009
文献标志码:
A
摘要:
目的 探讨垂体腺瘤转化生长因子-β1（TGF-β1）和结缔组织生长因子（CTGF）的表达及意义。方法 收集手术切除且病理学证实的垂体腺瘤标本58例，根据术前MRI检查和术中发现分为纤维化垂体腺瘤（19例）和非纤维化垂体腺瘤（39例）。采用逆转录聚合酶链式反应检测TGF-β1和CTGF mRNA表达水平。结果 与非纤维化垂体腺瘤相比，纤维化垂体腺瘤TGF-β1和CTGF mRNA表达水平均显著增高（P<0.05）。结论 TGF-β1和CTGF高表达可能垂体腺瘤纤维化有关。
Abstract:
Objective To explore the expressions of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) in the pituitary adenomas, and their role of in the pathogenesis of pituitary adenomas fibrosis. Methods The mRNA expression levels of TGF-β1 and CTGF were determined respectively by reverse transcription- polymerase chain reaction in 19 samples of fibrosis pituitary adenomas and 39 samples of non-fibrosis pituitary adenomas. Results The levels of TGF-β1 mRNA expression in the fibrosis pituitary adenomas and non-fibrosis pituitary adenomas were 0.720±0.102 and 0.519±0.093 respectively. The levels of CTGF mRNA expression in the fibrosis adenomas and the non-fibrosis pituitary adenomas were 0.487±0.110 and 0.312±0.123 respectively. There were significantly differences in the levels of TGF-β1 and CTGF mRNA expressions between both the groups (P<0.05). Conclusion That the levels of TGF-β1 and CTGF mRNA expressions in the fibrosis pituitary adenomas is significantly higher than those in the non-fibrosis pituitary adenomas suggests that TGF-β1 and CTGF may take part in the pathogenesis of the pituitary adenomas fibrosis.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：辽宁省自然科学基金资助项目（2014021097）
更新日期/Last Update: 2015-03-30