[1]乔建华　海　燕.内镜下经蝶入路切除垂体腺瘤术后颅内感染的危险因素分析[J].中国临床神经外科杂志,2017,(06):413-415.[doi:10.13798/j.issn.1009-153X.2017.06.016]
　QIAO Jian-hua,HAI Yan..Risk factors relate to intracranial infection after endoscope-assisted surgery through endonasal transsphenoidal approach for pituitary adenomas[J].,2017,(06):413-415.[doi:10.13798/j.issn.1009-153X.2017.06.016]
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内镜下经蝶入路切除垂体腺瘤术后颅内感染的危险因素分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年06期
页码:
413-415
栏目:
论著
出版日期:
2017-06-25

文章信息/Info

Title:
Risk factors relate to intracranial infection after endoscope-assisted surgery through endonasal transsphenoidal approach for pituitary adenomas
文章编号:
1009-153X（2017）06-0413-03
作者:
乔建华　海　燕
024000 内蒙古自治区，赤峰市医院神经外科
Author(s):
QIAO Jian-hua;  HAI Yan.
Department of Neurosurgery, Chifeng Municipal Hospital, Chifeng 024000, China
关键词:
垂体腺瘤; 经蝶入路; 手术; 内镜; 颅内感染; 危险因素
Keywords:
Pituitary adenomas;  Endoscope-assisted surgery;  Endonasal transsphenoidal approach;  Intracranial infection;  Risk
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2017.06.016
文献标志码:
A
摘要:
目的 探讨内镜下经蝶入路切除垂体腺瘤术后发生颅内感染的危险因素。方法 回顾性分析2012年1月至2016年1月内镜下经蝶入路手术治疗的123例垂体腺瘤的临床资料，采用多因素Logistic回归分析检验术后发生颅内感染的危险因素。结果 123例中，术后发生颅内感染11例（8.94%）。多因素Logistic回归分析结果显示，糖尿病、手术时间≥4 h、有脑脊液漏、术前使用激素是内镜下经蝶入路切除垂体腺瘤术后发生颅内感染的危险因素（P<0.05）。结论 内镜下经蝶入路切除垂体腺瘤术后发生颅内感染的危险因素众多，临床应根据这些危险因素采取预防性处理，以减少颅内感染的发生率。
Abstract:
Objective To investigate the risk factors related to the intracranial infection after endoscope-assisted surgery through endonasal transsphenoidal approach for pituitary adenomas. Methods The clinical data of 123 patients with pituitary adenomas, who were treated by endoscope-assisted surgery through endonasal transsphenoidal approach from January, 2012 to January, 2016 were analyzed retrospectively. The risk factors related to the postoperative intracranial infection were analyzed by multivariate Logistic regression analysis. Results The rate of intracranial infection occurrence was 8.94% (11/123). The multivariate Logistic regression analysis showed that the risk factors related to the intracranial infection after endonasal transspheaoidal surgery included diabetes, surgery time ≥4 h, cerebrospinal fluid leakage and preoperative use of hormone (P<0.05). Conclusion The intracranial infection after the endoscopic endonasal transsphenoidal surgery is related to many factors including diabetes, surgery time ≥4 h, cerebrospinal fluid leakage, preoperative use of hormone. The susceptible patients with above-mentioned risk factors should be given more attention and preventive treatment in order to reduce the incidence of intracranial infection.

参考文献/References:

[1] 王亚平，贾晓雄，王　珺，等. 神经内镜下与显微镜下手术 切除垂体腺瘤的疗效分析[J]. 中国临床神经外科杂志， 2016，21（3）：145-149.
[2] Ewelina L, Woiciech L. The importance of electrophysiolo- gical tests in early diagnosis of optic nerve dysfunction coexisting with pituitary adenomas--review and own expe- rience [J]. Klin Oczna, 2015, 117(1): 50-55.
[3] 王玉玉，李　刚，李　毅，等. 神经内镜下经单鼻孔蝶窦入 路垂体腺瘤切除术的临床效果分析[J]. 第三军医大学学 报，2013，35（12）：1317-1318.
[4] Xie R, He WQ, Shen M, et al. Specific inhibition of mTOR pathway induces anti-proliferative effect and decreases the hormone secretion in cultured pituitary adenoma cells [J]. J Neurooncol, 2015, 125(1): 79-89.
[5] 中华人民共和国卫生部. 医院感染诊断标准（试行)[J]. 现 代实用医学，2003，15（7）：460-465.
[6] 周待令. 经鼻蝶神经内镜结合磨钻辅助下垂体腺瘤切除 术临床分析[J]. 中国实用神经疾病杂志，2013，16（23）： 41-43.
[7] Chen XZ, Xue F, Xie TH, et al. Retraction Note to: Silen- cing of the Smad nuclear interacting protein 1 (SNIP1) by siRNA inhibits proliferation and induces apoptosis in pitui- tary adenoma cells [J]. Tumour Biol, 2015, 36(9): 7301.
[8] 李　俊，王　雷，王俊文，等. 经鼻蝶入路显微手术切除垂 体腺瘤63例[J]. 中国临床神经外科杂志，2010，15（12）： 726-728.
[9] 程　友，程　朋，刘开东，等. 经鼻蝶入路手术治疗垂体腺 瘤术后并发症[J].中国微侵袭神经外科杂志，2014，19 （2）：76-77.
[10] 郑文键，李维平，纪　涛，等. 神经内镜经鼻蝶入路垂体瘤 切除术的临床疗效和并发症分析[J]. 中华神经医学杂 志，2015，14（6）：609-613.
[11] 徐文俊，王　荣，黄　勇. 单鼻孔经蝶入路显微手术切除 垂体腺瘤后脑脊液鼻漏的相关因素分析及防治[J]. 重庆 医学，2013，42（20）：2366-2368.
[12] 胡爱香，李　静，石月欣，等. 垂体腺瘤患者术后颅内感染 影响因素与疾病负担分析[J].中华医院感染学杂志， 2016，26（11）：2488-2490.

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备注/Memo

备注/Memo:
基金项目：内蒙古自治区自然科学基金（2012MS1209）
更新日期/Last Update: 2017-06-25