[1]季欢欢,冯蒙蒙,李靖,等.RAB1A在垂体腺瘤组织中的表达及临床意义[J].中国临床神经外科杂志,2022,27(06):455-457.[doi:10.13798/j.issn.1009-153X.2022.06.007]
　JI Huan-huan,FENG Meng-meng,LI Jing,et al.Expression of RAB1A in pituitary adenoma tissues and its clinical significance[J].,2022,27(06):455-457.[doi:10.13798/j.issn.1009-153X.2022.06.007]
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RAB1A在垂体腺瘤组织中的表达及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年06期
页码:
455-457
栏目:
论著
出版日期:
2022-06-30

文章信息/Info

Title:
Expression of RAB1A in pituitary adenoma tissues and its clinical significance
文章编号:
1009-153X(2022)06-0455-03
作者:
季欢欢; 冯蒙蒙; 李靖; 赵宗仁; 董秋秀; 郑金玉; 陈中俊
223001 江苏淮安，徐州医科大学附属淮安医院神经外科（季欢欢、冯蒙蒙、李靖、赵宗仁、董秋秀、郑金玉、陈中俊）
Author(s):
JI Huan-huan;  FENG Meng-meng;  LI Jing;  ZHAO Zong-ren;  DONG Qiu-xiu;  ZHENG Jin-yu;  CHEN Zhong-jun
Department of Neurosurgery, Huai'an Hospital Affiliated to Xuzhou Medical University, Huai'an 223001, China
关键词:
垂体腺瘤; 肿瘤侵袭性; 基因表达; RAB1A
Keywords:
Pituitary adenoma;  Ras-related protein Rab-1A;  RAB1A;  Tumor invasiveness;  Gene expression
分类号:
R739.41;Q786
DOI:
10.13798/j.issn.1009-153X.2022.06.007
文献标志码:
A
摘要:
目的 探讨RAB1A在垂体腺瘤（PA）组织中的表达及临床意义。方法 收集2018年1月至2021年8月手术切除并经术后病理确诊的104例PA，根据Knosp分类法判断肿瘤侵袭性。用免疫组织化学染色法和免疫印迹法检测PA组织RAB1A的表达水平。结果 104例PA中，侵袭性41例，非侵袭性63例。侵袭性PA组织RAB1A高表达率为[65.85%（27/41）]明显高于非侵袭性PA组织[36.51%（23/63）；P<0.05]。侵袭性PA组织RAB1A蛋白相对表达量（2.87±0.54）明显高于非侵袭性PA组织[（1.67±0.48）；P<0.05]。多因素logistic回归分析显示RAB1A高表达（OR=1.908；95% CI 1.004~3.786；P=0.003）是PA侵袭性生长的独立影响因素。ROC曲线分析显示RAB1A鉴别PA侵袭性生长的曲线下面积为0.851，灵敏度、特异度分别为85.13%和79.12%。结论RAB1A的表达水平与PA的侵袭性有关，检测RAB1A可辅助评估PA的侵袭性。
Abstract:
Objective To investigate the expression of Ras-related protein Rab-1A (RAB1A) in pituitary adenoma (PA) tissues and its clinical significance. Methods The expression of RAB1A was detected in PA tissues obtained form 104 PA patients who underwent surgery from January 2018 to August 2021 using immunohistochemical staining and Western-bloting, respectively. The invasiveness of PA was assessed by Knosp grade. Results Of 104 PA patients, 41 patients were classified as invasive PA and 63 as non-invasive. The high expression rate of RAB1A in invasive PA tissues [65.85% (27/41)] was significantly higher than that in non-invasive PA tissues [36.51% (23/63); P<0.05]. The relative expression of RAB1A protein in invasive PA tissues (2.87±0.54) was significantly higher than that in non-invasive PA tissues [(1.67±0.48); P<0.05]. multivariate logistic regression analysis showed that high expression of RAB1A was an independent risk factor for PA invasion (OR=1.908; 95%CI 1.004~3.786; P=0.003). ROC curve analysis showed a area under curve of 0.851, a sensitivity of 85.13% and a specificity of 79.12% for RAB1A expression to differentiate the invasiveness of PA. Conclusions The expression level of RAB1A is related to the invasiveness of PA, and detection of RAB1A can help evaluating the invasiveness of PA.

参考文献/References:

[1] Han C, Lin S, Lu X, et al. Tumor-associated macrophages: new horizons for pituitary adenoma researches [J]. Front Endocrinol (Lausanne), 2021, 12: 785050.
[2] Wu Y, Yang D, Chen GY. Targeted disruption of Rab1a causes early embryonic lethality [J]. Int J Mol Med, 2022, 49(4): 46.
[3] Peng C, Li X, Ye Z, et al. Rab1A promotes cell proliferation and migration by upregulating Gli1 in colorectal cancer [J]. Sci Rep, 2021, 11(1): 16243.
[4] Su H, Li T, Li C, et al. Expression of Rab1A in bladder cancer and its clinical implications [J]. Exp Ther Med, 2020, 20(5): 44.
[5] Yang XZ, Chen XM, Zeng LS, et al. Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma [J]. Aging (Albany NY), 2020, 12(20): 20380-20395.
[6] Ren B, Wang L, Nan Y, et al. RAB1A regulates glioma cellular proliferation and invasion via the mTOR signaling pathway and epithelial-mesenchymal transition [J]. Future Oncol, 2021, 17(24): 3203-3216.
[7] 岳　成，石文健，刘永亮，等. 侵袭性功能性垂体腺瘤病人低氧诱导因子1α诱导血管生成相关基因的表达及临床意义[J]. 实用心脑肺血管病杂志，2022，30（1）：27-31.
[8] 苗发安，梁　君，张　慧，等. 端粒保护蛋白-1和端粒结合因子-1在侵袭性垂体瘤的表达及其临床意义[J]. 临床神经外科杂志，2020，17（2）：135-139.
[9] 王　冉，周　琦，杨　坤. 垂体腺瘤侵袭性相关指标的研究进展[J]. 临床神经外科杂志，2021，18（2）：226-228.
[10] Li Z, Li Y, Jia Y, et al. Rab1A knockdown represses proliferation and promotes apoptosis in gastric cancer cells by inhibition of mTOR/p70S6K pathway [J]. Arch Biochem Biophys, 2020, 685: 108352.
[11] Huang T, Chen B, Wang F, et al. Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer [J]. Cancer Lett, 2021, 523: 182-194.

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备注/Memo

备注/Memo:
（2022-01-12收稿，2022-04-15修回）
通讯作者：冯蒙蒙，E-mail：1149596152@qq.com
更新日期/Last Update: 2022-07-31