[1]祝启海　夏国庆　宋　伟.垂体腺瘤组织DCX表达水平与肿瘤侵袭性的关系[J].中国临床神经外科杂志,2021,26(08):597-599.[doi:10.13798/j.issn.1009-153X.2021.08.008]
　ZHU Qi-hai,XIA Guo-qing,SONG Wei..Relationship between DCX expression and invasion of pituitary adenoma[J].,2021,26(08):597-599.[doi:10.13798/j.issn.1009-153X.2021.08.008]
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垂体腺瘤组织DCX表达水平与肿瘤侵袭性的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年08期
页码:
597-599
栏目:
论著
出版日期:
2021-08-25

文章信息/Info

Title:
Relationship between DCX expression and invasion of pituitary adenoma
文章编号:
1009-153X（2021）08-0597-03
作者:
祝启海　夏国庆　宋　伟
Author(s):
ZHU Qi-hai;  XIA Guo-qing;  SONG Wei.
Department of Neurosurgery, The First Affiliated Hospital of Henan Polytechnic University/ Jiaozuo Second People’s Hospital, Jiaozuo 454000, China
关键词:
垂体腺瘤; 双皮质素; 肿瘤侵袭性; 危险因素
Keywords:
Pituitary adenoma;  Doublecortin;  Tumor invasiveness;  Risk factors
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2021.08.008
文献标志码:
A
摘要:
目的 探讨垂体腺瘤组织双皮质素（DCX）的表达水平与肿瘤侵袭性的关系。方法 采用免疫组化染色和qRT-PCR检测2017年1月~2020年1月手术切除的88例垂体腺瘤组织和56例瘤旁垂体组织DCX表达情况和DCX mRNA表达量。根据Knosp分类方法评估肿瘤侵袭性，并分成侵袭组、无侵袭组。利用多因素logistic回归分析检验发生侵袭性的危险因素。受试者工作特征（ROC）曲线分析DCX mRNA预测垂体腺瘤侵袭性的效能。结果 88例中，侵袭组41例，无侵袭组47例。垂体腺瘤组织DCX阳性率（71.59%，63/88）明显高于瘤旁组织（17.86%，10/56；P<0.05）。垂体腺瘤组织DCX mRNA表达量（5.65±1.87）明显高于瘤旁组织（0.85±0.28；P<0.05）。侵袭组DCX mRNA表达量（6.42±0.86）明显高于无侵袭组（4.98±0.94；P<0.05）。多因素logistic回归分析显示DCX表达阳性是垂体腺瘤发生侵袭的独立危险因素（P<0.05）。ROC曲线显示，DCX mRNA表达量预测垂体腺瘤侵袭性的曲线下面积为0.775（95% CI 0.676~0.874；P<0.001），最佳界值为5.640，敏感度为78.00%，特异度为61.70%。结论 垂体腺瘤组织DCX呈高表达，检测DCX表达水平对肿瘤侵袭性有一定的预测作用。
Abstract:
Objective To explore the relationship between expression of doublecortin (DCX) in pituitary adenoma (PA) tissues and the invasion of PA. Methods The positive expression rate and mRNA level of DCX were detected in PA tissues obtained from 88 patients with PA who underwent microsurgery from January 2017 to January 2020 and in tissues adjacent to the PA obtained from 56 PA patients by immunohistochemistry and qRT-PCR, respectively. The PA was divided into invasive group and non-invasive group according to the Knosp classification method. Multivariate logistic regression was used to analyze the risk factors for the invasion of PA. Receiver operating characteristic (ROC) curve was used to analyze the predictive power of DCX mRNA level on the the invasiveness of PA. Results The positive expression rate (71.59%, 63/88) and mRNA level (5.65±1.87) of DCX in PA tissues were significantly higher than those [(17.86%, 10/56) and (0.85±0.28), respectively] in tissues adjacent to PA (P<0.05). The level of DCX mRNA in invasive group (6.42±0.86) was significantly higher than that (4.98±0.94) in non-invasive group (P<0.05). Multivariate logistic regression analysis indicated that positive expression of DCX was an independent risk factor for invasion of PA (P<0.05). ROC curve analysis showed that the area under the curve of DCX mRNA to predict the invasion of PA was 0.775 (95% CI 0.676~0.874; P<0.001), and the best cut-off value of was 5.640, with a sensitivity of 78.00% and a specificity of 61.70%. Conclusions DCX is highly expressed in PA tissues, and the detection of DCX expression level has a certain predictive effect on the invasiveness of PA.

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备注/Memo

备注/Memo:
作者单位：454000 河南焦作，河南理工大学第一附属医院神经外科（祝启海、夏国庆、宋　伟）
更新日期/Last Update: 1900-01-01