[1]邓学云　刘　毅　范润金　刘丽华　夏祥国.E-cadherin与脑膜瘤分级及瘤周水肿的关系[J].中国临床神经外科杂志,2016,(04):213-215.[doi:10.13798/j.issn.1009-153X.2016.04.007]
　DENG Xue-yun,LIU Yi,FAN Run-jin,et al.Relationship of E-cadherin with the pathological grade of meningioma and peritumoral brain edema in patients with meningioma[J].,2016,(04):213-215.[doi:10.13798/j.issn.1009-153X.2016.04.007]
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E-cadherin与脑膜瘤分级及瘤周水肿的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年04期
页码:
213-215
栏目:
论著
出版日期:
2016-04-25

文章信息/Info

Title:
Relationship of E-cadherin with the pathological grade of meningioma and peritumoral brain edema in patients with meningioma
文章编号:
1009-153X（2016）04-0213-03
作者:
邓学云　刘　毅　范润金　刘丽华　夏祥国
637000 四川，南充市中心医院神经外科（邓学云、刘　毅、范润金），老年病科（刘丽华）；646000 四川泸州，西南医科大学附属医院神经外科（夏祥国）
Author(s):
DENG Xue-yun1;  LIU Yi1;  FAN Run-jin1;  LIU Li-hua2;  XIA Xiang-guo3.
1. Department of Neurosurgery, Central Hospital of Nanchong City, Nanchong 637000, China; 2. Department of Geriatrics, Central Hospital of Nanchong City, Nanchong 637000, China; 3. Department of Neurosurgery, Affiliated Hospital, Southwest Medical University, Luzhou 646000, China
关键词:
脑膜瘤; 瘤周水肿; 上皮钙粘附蛋白; 相关性
Keywords:
Meningioma;  Epithelial cadherin;  Expression;  Peritumoral edema
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2016.04.007
文献标志码:
A
摘要:
目的 探讨上皮钙粘附蛋白（E-cad）与脑膜瘤病理分级及瘤周水肿之间的关系。方法 收集2013年1月至2015年1月经手术切除及病理组织学证实的脑膜瘤标本66例，另取15例颅脑损伤后行内外减压术的正常蛛网膜组织作为对照。采用免疫组织化学方法检测E-cad的表达；头颅MRI评估瘤周水肿的程度。结果 正常蛛网膜组织E-cad表达强度明显高于脑膜瘤组织（P<0.05）。脑膜瘤e-cad蛋白表达强度与脑膜瘤病理级别呈负相关（rs>P<0.01）。脑膜瘤e-cad蛋白表达强度与瘤周水肿级别呈负相关（rs>P<0.01）。>结论 E-cad可能与脑膜瘤瘤周水肿的形成有关。
Abstract:
Objective To explore the relationship of epithelial cadherin (E-cad) with the pathological grades of meningiomas and peritumoral brain edema (PTBE). Methods The expression of E-cad was determined by immunohistochemical technique in 66 cases of meningiomas tissues, including 53 pathological grade Ⅰ meningiomas, 7 grade Ⅱ and 6 grade Ⅲ, and 15 cases of normal arachnoid tissues. The grades of PTBE were assessed by MRI. Results The level of E-cad expression was significantly higher in the arachnoid tissues than that in the meningioma tissues (P<0.05). the="" level="" of="" e-cad="" expression="" was="" significantly="" higher="" in="" grade="" ⅰ="" meningioma="" tissues="" than="" those="" grades="" ⅱ="" and="" ⅲ="" meningiomas="" (P<0.05). the="" levels="" of="" e-cad="" expression="" in="" meningiomas="" tissues="" were="" negatively="" related="" to="" meningioma="" grades="" (rs="-0.577,">P<0.01). the="" levels="" of="" e-cad="" expression="" in="" meningioma="" tissues="" were="" negatively="" related="" to="" peritumoral="" edema="" grades="" (rs="-0.668,">P

参考文献/References:

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更新日期/Last Update: 2016-04-30