[1]邢琼波　赵秀英　吴小娜.左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁患儿的疗效观察[J].中国临床神经外科杂志,2018,(05):322-324338.[doi:10.13798/j.issn.1009-153X.2018.05.006]
　XING Qiong-bo,ZHAO Xiu-ying,WU Xiao-na..Curative effect of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression[J].,2018,(05):322-324338.[doi:10.13798/j.issn.1009-153X.2018.05.006]
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左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁患儿的疗效观察()

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年05期
页码:
322-324338
栏目:
论著
出版日期:
2018-05-25

文章信息/Info

Title:
Curative effect of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression
文章编号:
1009-153X（2018）05-0322-03
作者:
邢琼波　赵秀英　吴小娜
作者单位：570203 海口，海南省人民医院康复中心（邢琼波、赵秀英、吴小娜）
Author(s):
XING Qiong-bo;  ZHAO Xiu-ying;  WU Xiao-na.
Centre of Rehabilitation, Peoples’ Hospital of Hainan Province, Haikou 570203, China
关键词:
癫痫; 抑郁症; 儿童; 左乙拉西坦; 盐酸舍曲林; 疗效
Keywords:
Epilepsy;  Levetiracetam;  Sertraline hydrochloride;  Depression;  Children
分类号:
R 742.1; R 749.94
DOI:
10.13798/j.issn.1009-153X.2018.05.006
文献标志码:
A
摘要:
目的 探讨左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁症儿童的临床疗效。方法 回顾性分析112例6~15岁癫痫伴抑郁症的临床资料，按年龄分为学龄组（6~12岁，56例）和少年组（13~15岁，56例），评估治疗前后癫痫发作频率、认知功能（WISC-CR）、汉密尔顿抑郁量表17项（HAMD-17）、生活质量、身体质量指数（BMI）、不良反应发生率。结果 与治疗前相比，两组治疗6、12个月，癫痫发作频率、认知功能、HAMD-17评分、生活质量均显著改善（P<0.05）；同时，学龄组癫痫发作频率、认知功能、HAMD-17评分、生活质量均显著优于少年组（P<0.05）；两组治疗后BMI、不良反应发生率无统计学差异（P>0.05）。结论 采用左乙拉西坦联合盐酸舍曲林治疗癫痫伴抑郁症儿童可获得显著的疗效，其中学龄组疗效优于少年组。
Abstract:
Objective To evaluate the clinical curative effects of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression. Methods The clinical data of 112 epilepsy children with depression aged 6~15 years, of whom, 56 were 6~12 years old (group A) and 56 were13~15 years old (group B), were analyzed retrospectively. All the children were treated by levetiracetam combined with sertraline hydrochloride for 12 months. The frequency of seizures, Wechsler intelligence scale for children revised in China (WISC-CR), Hamilton Depression Rating Scale 17 (HAMD-17), and quality of life in children with epilepsy (QOLCE), body mass index (BMI) and incidence of adverse reactions in both groups were determined and analyzed before and after the treatment. Results The scores of WISC-CR and QOLCE were significantly higher and the frequency of seizures and the scores of HAMD-17 were significantly lower in both the groups after the treatment than those before the treatment (P<0.05). The scores of WISC-CR and QOLCE were significantly higher and the frequency of seizures and the scores of HAMD-17 were significantly lower in group A than those in group B after the treatment (P<0.05). However, there were insignificant differences in the BMI and the incidence of adverse reactions between the two groups after the treatment (P>0.05). Conclusions The curative effects of levetiracetam combined with sertraline hydrochloride on epilepsy children with depression are good in all the age groups, but their effects on epilepsy children with depression aged 6~12 years are better than those on epilepsy children with depression aged 13~15 years.

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更新日期/Last Update: 2018-04-25