[1]张　坚　方　媛　姚　亮　刘建雄.胶质瘤部位与术前癫痫发生率相关性的Meta分析[J].中国临床神经外科杂志,2018,(05):318-321.[doi:10.13798/j.issn.1009-153X.2018.05.005]
　Correlativity between glioma location and preoperative glioma-related epilepsy: a meta-analysis.Correlativity between glioma location and preoperative glioma-related epilepsy: a meta-analysis[J].,2018,(05):318-321.[doi:10.13798/j.issn.1009-153X.2018.05.005]
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胶质瘤部位与术前癫痫发生率相关性的Meta分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年05期
页码:
318-321
栏目:
论著
出版日期:
2018-05-25

文章信息/Info

Title:
Correlativity between glioma location and preoperative glioma-related epilepsy: a meta-analysis
文章编号:
1009-153X（2018）05-0318-04
作者:
张　坚　方　媛　姚　亮　刘建雄
作者单位：750004 银川，宁夏医科大学临床医学院神经外科系（张　坚）；730000 兰州，兰州大学循证医学中心（方　媛、姚　亮）；730000 兰州，甘肃省人民医院神经外科（刘建雄）
Author(s):
Correlativity between glioma location and preoperative glioma-related epilepsy: a meta-analysis
1. Department of Neurosurgery, Clinical Medical School, Ningxia Medical University, Yinchuan 750004, China; 2. Evidence-Based Medicine Center, Lanzhou University, Lanzhou 730000, China; 3.Department of Neurosurgery, Gansu Provincial People’s Hospital, Lanzhou 730000, China
关键词:
胶质瘤; 胶质瘤相关性癫痫; 肿瘤部位; Meta分析
Keywords:
Gliomas;  Epilepsy;  Location;  Correlativity;  Meta-analysis
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2018.05.005
文献标志码:
A
摘要:
目的 系统评价胶质瘤部位与术前癫痫发生率的相关性。方法 计算机系统检索PubMed、Embase、Web of Science、Cochrane Library等英文数据库，以及CBM和CNKI等中文数据库，全面收集关于脑胶质瘤的部位与术前癫痫发生率的相关性研究，检索时限截至 2017年1月。采用Stata12.0软件进行Meta分析。结果 共纳入15个研究，包括4 013例胶质瘤。Meta分析结果显示：额叶胶质瘤术前癫痫的风险较非额叶胶质瘤高（OR=1.43，95% CI 1.03~1.98，P=0.031），枕叶胶质瘤术前癫痫的风险较非枕叶胶质瘤低（OR=0.49，95% CI 0.26~0.93，P=0.014），而颞叶、顶叶、岛叶胶质瘤与术前癫痫无明显相关性（P>0.05）。结论 胶质瘤部位与术前癫痫发生率具有一定相关性，额叶胶质瘤术前癫痫发生率高，枕叶胶质瘤最低，而颞叶、岛叶及顶叶胶质瘤术前癫痫风险暂未发现明显统计学差异。
Abstract:
Objective To evaluate the relationship between the glioma location and preoperative glioma-related epilepsy (GRE) in patients with gliomas. Methods The databases including PubMed, EMBASE, Web of Science, China Biology Medicine, the Cochrane Library and CNKI were systematically searched for original articles of relationship between the glioma location and preoperative GRE published before the January, 2017 including randomized control study and case-control study. The meta-analysis was performed by Stata 12.0 software. Results A total of 4, 013 participants in 15 population-based studies were included in this meta-analysis. Meta analysis showed that gliomas in the frontal lobe were significantly associated with increased preoperative GRE risk (OR=1.43, 95% CI: 1.03~1.98, P=0.031) and the patients with gliomas in the occipital lobes had relatively low preoperative GRE (OR=0.49, 95% CI: 0.26~0.93, P=0.014). Conclusions Compared with those in the patients with temporal, parietal and insular lobes gliomas, the incidence of preoperative GRE was the highest in the patients with frontal gliomas, and the lowest in the patients with occipital gliomas. Our findings provide a clinical basis for the management of epileptic seizures in patients with gliomas. Due to the effect of confounding factors on the outcomes of the present study, the above conclusions need to be further verified by large-scale high-quality research.

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备注/Memo

备注/Memo:
通讯作者：刘建雄，E-mail：ljx626390@163.com.
更新日期/Last Update: 2018-04-25