[1]李佩恒,彭彪.环状RNA在胶质瘤DNA损伤修复中的研究现况[J].中国临床神经外科杂志,2024,29(10):629-632.[doi:10.13798/j.issn.1009-153X.2024.10.013]
 LI Pei-heng,PENG Biao.Research status of circular RNA in DNA damage repair of glioma[J].,2024,29(10):629-632.[doi:10.13798/j.issn.1009-153X.2024.10.013]
点击复制

环状RNA在胶质瘤DNA损伤修复中的研究现况()
分享到:

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
29
期数:
2024年10期
页码:
629-632
栏目:
综述
出版日期:
2024-10-30

文章信息/Info

Title:
Research status of circular RNA in DNA damage repair of glioma
文章编号:
1009-153X(2024)10-0629-04
作者:
李佩恒彭彪
510095广州,广州医科大学附属肿瘤医院神经外科(李佩恒、彭彪)
Author(s):
LI Pei-heng PENG Biao
Department of Neurosurgery, Affiliated Cancer Hospital and Instituted of Guangzhou Medical University, Guangzhou 510095, China
关键词:
胶质瘤DNA损伤修复环状RNA(circRNA)
Keywords:
Glioma DNA damage repair Circular RNA (circRNA)
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2024.10.013
文献标志码:
A
摘要:
胶质瘤是一种恶性度高、复发率高、预后差的中枢神经系统肿瘤。DNA损伤修复在胶质瘤发生发展中起重要作用,并且影响胶质瘤放化疗的效果。环状RNA(circRNA)是一种单链闭环非编码RNA,具有高度的保守性和特异性,可通过调节DNA损伤修复过程影响胶质瘤的发生、发展及治疗效果。本文总结circRNAs调控DNA损伤修复的病理生理机制,探讨circRNAs在胶质瘤DNA损伤修复过程中的治疗前景。
Abstract:
Glioma is a tumor of the central nervous system characterized by high malignancy, high recurrence rate, and poor prognosis. DNA damage repair plays a vital role in the genesis and progression of glioma and significantly influences the efficacy of radiotherapy and chemotherapy. Circular RNA (circRNA) is a type of single-stranded closed-loop non-coding RNA, possessing high conservation and tissue specificity. It can impact the occurrence, development, and therapeutic outcome of glioma by regulating the DNA damage repair process. This paper summarizes the pathophysiological mechanisms by which circRNAs regulate DNA damage repair and explores their therapeutic prospects in DNA damage repair of glioma.

参考文献/References:

[1] RAYBAK-WOLF A, STOTTMEISTER C, GLAZAR P, et al. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed [J]. Mol Cell, 2015, 58(5): 870-885.
[2] DONG MX, SUN XH, XU C, et al. DNA damage repair and cell cycle arrest [J]. Int JBiomed Eng, 2021, 44(4): 329-333, 339. 董明新,孙晓辉,徐 畅,等. DNA损伤修复与细胞周期阻滞[J]. 国际生物医学工程杂志,2021,44(4):329-333,339.
[3] ZHANG WJ, LIU QR, ZHANG M, et al. Research progress on DNA damage repair and glioma resistance to temozolomide [J]. West China J Pharm Sci, 2017, 32(5): 555-558. 张文静,刘倩蓉,张 敏,等. DNA损伤的修复与胶质瘤对替莫唑胺耐药性的研究进展[J]. 华西药学杂志,2017,32(5):555-558.
[4] CHRISTMANN M, KAINA B. Epigenetic regulation of DNA repair genes and implications for tumor therapy [J]. Mutat Res Rev Mutat Res, 2019, 780: 15-28.
[5] YUAN F, ZHANG S, SUN Q, et al. Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma [J]. CNS Neurosci Ther, 2022, 28(6): 897-912.
[6] LEI B, HUANG Y, ZHOU Z, et al. Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression [J]. J Cell Biochem, 2019, 120(4): 6698-6708.
[7] OLIVEIRA TT, COUTINHO LG, DE OLIVEIRA LOA, et al. APE1/ Ref-1 role in inflammation and immune response [J]. Front Immunol, 2022, 13: 793096.
[8] FROSINA G. DNA repair and resistance of gliomas to chemotherapy and radiotherapy [J]. Mol Cancer Res, 2009, 7(7): 989-99.
[9] KUANG YB. Research on the mechanism of p21 enhancing the radioresistance of glioma under hypoxic conditions [D]. University of Chinese Academy of Sciences, 2021. 匡彦蓓. p21增强乏氧条件下胶质瘤辐射抗性的机制研究[D]. 中国科学院大学,2021.
[10] MYLLYNEN L, KWIATKOWSKI M, GLEIONER L, et al. Quantitative proteomics unveiled: regulation of DNA double strand break repair by EGFR involves PARP1 [J]. Radiother Oncol, 2015, 116 (3): 423-30.
[11] GUPTA SK, KIZILBASH SH, CARLSON BL, et al. Delineation of MGMT hypermethylation as a biomarker for veliparib-mediated temozolomide-sensitizing therapy of glioblastoma [J]. J Natl Cancer Inst, 2015, 108(5): djv369.
[12] CORNELISSEN B, WALLER A, ABLE S, et al. Molecular radiotherapy using cleavable radioimmunoconjugates that target EGFR and γH2AX [J]. Mol Cancer Ther, 2013, 12(11): 2472-82.
[13] GAO X, XIA X, LI F, et al. Circular RNA-encoded oncogenic Ecadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling [J]. Nat Cell Biol, 2021, 23 (3): 278-291.
[14] LIU Y, LI Z, ZHANG M, et al. Rolling-translated EGFR variants sustain EGFR signaling and promote glioblastoma tumorigenicity [J]. Neuro Oncol, 2021, 23(5): 743-756.
[15] GUO Q, GUO J, LIU W, et al. Circ-EGFR functions as an inhibitory factor in the malignant progression of glioma by regulating the miR183-5p/TUSC2 Axis [J]. Cell Mol Neurobiol, 2022, 42(7): 2245-2256.
[16] WESTPHAL M, MAIRE CL, LAMSZUS K. EGFR as a target for glioblastoma treatment: an unfulfilled promise [J]. CNS Drugs, 2017, 31(9): 723-735.
[17] ROBERT M, WASTIE M. Glioblastoma multiforme: a rare manifestation of extensive liver and bone metastases [J]. Biomed Imaging Interv J, 2008, 4(1): e3.
[18] KAO GD, JIANG Z, FERNANDES AM, et al. Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation [J]. J Biol Chem, 2007, 282(29): 21206-21212.
[19] HE Q, ZHAO L, LIU X, et al. MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change [J]. J Exp Clin Cancer Res, 2019, 38(1): 9.
[20] XIN J, ZHANG XY, SUN DK, et al. Up-regulated circular RNA hsa_circ_0067934 contributes to glioblastoma progression through activating PI3K-AKT pathway [J]. Eur Rev Med Pharmacol Sci, 2019, 23(8): 3447-3454.
[21] QIAO J, LIU M, TIAN Q, et al. Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling [J]. Life Sci, 2020, 245: 117363.
[22] WANG Y, CUI H, TAO S, et al. High canonical Wnt/β-catenin activity sensitizes murine hematopoietic stem and progenitor cells to DNA damage [J]. Stem Cell Rev Rep, 2020, 16(1): 212-221.
[23] LU Y, DENG X, XIAO G, et al. Circ_0001730 promotes proliferation and invasion via the miR-326/Wnt7B axis in glioma cells [J]. Epigenomics. 2019, 11(11): 1335-1352.
[24] YANG P, QIU Z, JIANG Y, et al. Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway [J]. Oncotarget. 2016, 7(39): 63449-63455.
[25] ZHOU Q, FU Q, SHAYA M, et al. Knockdown of circ_0055412 promotes cisplatin sensitivity of glioma cells through modulation of CAPG and Wnt/β-catenin signaling pathway [J]. CNS Neurosci Ther, 2022, 28(6): 884-896.
[26] PALMAI-PALLAG T, BACHRATI CZ. Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [J]. Microbes Infect, 2014, 16(10): 822-832.
[27] ZHAO S, LI B, ZHAO R, et al. Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway [J]. Oncogene, 2023, 42(2): 138-153.
[28] WANG M, SUO L, YANG S, et al. CircRNA 001372 reduces inflammation in propofol-induced neuroinflammation and neural apoptosis through PIK3CA/Akt/NF-κB by miRNA-148b-3p [J]. J Invest Surg, 2021, 34(11): 1167-1177.
[29] MEROLA E, CLAUDIO PP, GIORDANA A. p53 and the malignant progression of Barrett's esophagus [J]. J Cell Physiol, 2006, 206(3): 574-577.
[30] ENGELAND K. Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM [J]. Cell Death Differ, 2018, 25 (1): 114-132.
[31] LOU J, HAO Y, LIN K, et al. Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit gliomagenesis [J]. Mol Cancer, 2020, 19(1): 138.
[32] KARIMAN A, AHMADI Y, YOUSEFI B. Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage [J]. DNA Repair (Amst), 2016, 42: 63-71.
[33] ZHANG F, MAI SR, CAO FP, et al. MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion [J]. Hum Cell, 2019, 32(4): 540-547.

相似文献/References:

[1]常英男 王 策 赵天书.SOX2基因在胶质瘤中的表达及生物学作用[J].中国临床神经外科杂志,2016,(05):270.[doi:10.13798/j.issn.1009-153X.2016.05.005]
 CHANG Ying-nan,WANG Ce,ZHAO Tian-shu..Expression of SOX2 gene and its biological role in human gliomas[J].,2016,(10):270.[doi:10.13798/j.issn.1009-153X.2016.05.005]
[2]赛 克 陈忠平.胶质瘤的疗效评价[J].中国临床神经外科杂志,2016,(06):321.[doi:10.13798/j.issn.1009-153X.2016.06.001]
[3]许 耿 路俊锋 杨 忠 施建斌 吴秋月 王 烨 庄冬晓 吴劲松.神经电生理监测技术在功能区胶质瘤术中的应用[J].中国临床神经外科杂志,2016,(06):323.[doi:10.13798/j.issn.1009-153X.2016.06.002]
 XU Geng,LU Jun-feng,YANG Zhong,et al.Application of intraoperative neuroelectrophysiologic monitoring to gliomas resection in eloquent function brain regions[J].,2016,(10):323.[doi:10.13798/j.issn.1009-153X.2016.06.002]
[4]李剑峰 陈银生 赛 克 张湘衡 柯 超 杨群英 牟永告 许海雄 陈忠平.173例胶质瘤预后的影响因素分析[J].中国临床神经外科杂志,2016,(06):327.[doi:10.13798/j.issn.1009-153X.2016.06.003]
 LI Jian-feng,CHEN Yin-sheng,SAI Ke,et al.Prognostic factors for gliomas: analysis of 173 cases[J].,2016,(10):327.[doi:10.13798/j.issn.1009-153X.2016.06.003]
[5]云德波 杨宇焦 张 逵 范润金 张 渊 杜贻庆.瘤周谷氨酸、天门冬氨酸水平与胶质瘤继发性 癫痫的相关性[J].中国临床神经外科杂志,2016,(06):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
 YUN De-bo,YANG Yu-Jiao,ZHANG Kui,et al.Relationship of levels of glutamate and aspartate in peritumorous tissues with seizures in patients with gliomas[J].,2016,(10):331.[doi:10.13798/j.issn.1009-153X.2016.06.004]
[6]黄书岚 成于思 王 辉 汪超甲.FAK siRNA重组质粒的构建及其对胶质瘤U251细胞 增殖及侵袭能力的抑制作用[J].中国临床神经外科杂志,2016,(06):336.[doi:10.13798/j.issn.1009-153X.2016.06.006]
 HUANG Shu-lan,CHENG Yu-si,WANG Hui,et al.Construction of siRNA recombinant plasmid targeting focal adhesion kinase gene and its effect on the proliferation and invasiveness of human glioma U251cells[J].,2016,(10):336.[doi:10.13798/j.issn.1009-153X.2016.06.006]
[7]林 雨 张 恺 李 帅 杨学军.磁共振数字化手术单元在指导胶质瘤治疗中的作用[J].中国临床神经外科杂志,2016,(06):345.[doi:10.13798/j.issn.1009-153X.2016.06.009]
[8]戴黎明 徐成仕 王泽芬 曹长军 李志强.VEGF单抗对低氧环境下C6胶质瘤细胞侵袭性的影响[J].中国临床神经外科杂志,2016,(04):219.[doi:10.13798/j.issn.1009-153X.2016.04.009]
 DAI Li-ming,XU Cheng-shi,WANG Ze-fen,et al.Effect of nonoclonal antibody of VEGF on C6 glioma cells invasiveness under hypoxia and the role of FAK/Pyk2[J].,2016,(10):219.[doi:10.13798/j.issn.1009-153X.2016.04.009]
[9]彭泽生 田道锋 张申起 陈谦学.miR-370-3p对胶质母细胞瘤U87-MG细胞株增殖能力的影响[J].中国临床神经外科杂志,2016,(04):223.[doi:10.13798/j.issn.1009-153X.2016.04.010]
 PENG Ze-sheng,TIAN Dao-feng,ZHANG Shen-qi,et al.Effects of MircoRNA-370-3p on proliferation of glioma cell line U87-MG and its potential mechanism[J].,2016,(10):223.[doi:10.13798/j.issn.1009-153X.2016.04.010]
[10]冯 驰 郭双毅 程龙海 罗 杰.氯喹通过抑制自噬促进TRAIL诱导的胶质瘤细胞凋亡[J].中国临床神经外科杂志,2016,(04):227.[doi:10.13798/j.issn.1009-153X.2016.04.011]
 FENG Chi,GUO Shuang-yi,CHENG Long-hai,et al.Chloroquine promotes TRAIL-induced apoptosis of glioma cells through inhibition of autophagy[J].,2016,(10):227.[doi:10.13798/j.issn.1009-153X.2016.04.011]

备注/Memo

备注/Memo:
(2023-07-12收稿,2024-01-03修回)
通信作者:彭 彪,Email:pengbiaopengbiao@msn.com
更新日期/Last Update: 2024-10-30