[1]张志银　李　泽　李　华　张良君　杨　春.ERH在人脑胶质瘤中的表达及其与病人预后的关系[J].中国临床神经外科杂志,2020,(11):753-755.[doi:doi:10.13798/j.issn.1009-153X.2020.11.006]
　ZHANG Zhi-yin,LI Ze,LI Hua,et al.Expression of enhancer of rudimentary homolog in glioma tissues and its relationship with glioma patients’ prognoses[J].,2020,(11):753-755.[doi:doi:10.13798/j.issn.1009-153X.2020.11.006]
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ERH在人脑胶质瘤中的表达及其与病人预后的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年11期
页码:
753-755
栏目:
论著
出版日期:
2020-11-25

文章信息/Info

Title:
Expression of enhancer of rudimentary homolog in glioma tissues and its relationship with glioma patients’ prognoses
文章编号:
1009-153X（2020）11-0753-03
作者:
张志银　李　泽　李　华　张良君　杨　春
710043 西安，陕西省第四人民医院神经外科（张志银、李　泽、李　华、张良君）；725000 陕西，安康市人民医院神经外科（杨　春）
Author(s):
ZHANG Zhi-yin1;  LI Ze1;  LI Hua1;  ZHANG Liang-jun1;  YANG Chun2.
1. Department of Neurosurgery, The Fourth People’s Hospital of Shaanxi, Xi’an 710043, China; 2. Department of Neurosurgery, Ankang People’s Hospital, Ankang 725000, China
关键词:
胶质瘤; 未成熟同源蛋白增强子; 预后; 基因表达
Keywords:
Glioma;  Enhancer of the rudimentary homolog;  Prognosis
分类号:
R 739.41; Q 786
DOI:
doi:10.13798/j.issn.1009-153X.2020.11.006
文献标志码:
A
摘要:
目的 探讨未成熟同源蛋白增强子（ERH）在人脑胶质瘤组织中的表达及其与病人生存预后的关系。方法 免疫组织化学染色法检测2012年5月至2017年5月手术切除的121例胶质瘤组织和2012年5月~2017年5月颅脑损伤内减压术中切除的40例正常脑组织中ERH的表达水平。根据染色结果将胶质瘤分为高表达组和低表达组。采用多因素Cox比例回归风险模型分析胶质瘤病人总生存期（OS）和无进展生存期（PFS）的影响因素。结果 正常脑组织ERH高表达率（15.00%，6/40）明显低于胶质瘤组织（61.16%，74/121；P<0.05）。多因素Cox比例回归风险模型分析结果显示，WHO分级Ⅲ~Ⅳ级和ERH高表达是胶质瘤病人OS和PFS较短的独立影响因素（P<0.05）。生存曲线分析显示低表达组OS和PFS均明显高于高表达组（P<0.05）。结论 ERH在胶质瘤组织中高表达，并且与病人不良生存预后和肿瘤进展有关。
Abstract:
Objective To explore the expression of enhancer of rudimentary homolog (ERH) in glioma tissues and its relationship with the survival prognoses of glioma patients. Methods Immunohistochemical staining was used to detect the expression level of ERH in 121 glioma tissues obtained from 121 glioma patients underwent surgery from May 2012 to May 2017 and in 40 normal brain tissues obtained from 40 traumatic brain injury patients underwent decompressive craniectomy from May 2012 to May 2017. According to the staining results, the patients with glioma were divided into high expression group and low expression group. The multivariate Cox proportional regression risk model was used to analyze the overall survival (OS) and progression-free survival (PFS) of glioma patients. Results The high expression rate of ERH in normal brain tissue (15.00%, 6/40) was significantly lower than that (61.16%, 74/121) in glioma tissue (P<0.05). The results of multivariate Cox proportional regression risk model analysis showed that WHO grades Ⅲ~Ⅳ and high ERH expression were independent risk factors for shorter OS and PFS in patients with glioma (P<0.05). The OS and PFS of the low expression group were significantly higher than those of the high expression group (P<0.05). Conclusion ERH is highly expressed in glioma tissues, which is related to the poor survival prognoses of patients.

参考文献/References:

[1] Gusyatiner O, Hegi ME. Glioma epigenetics: from subclassification to novel treatment options [J]. Semin Cancer Biol, 2018, 51: 50-58.
[2] Weng MT, Tung TH, Lee JH, et al. Enhancer of rudimentaryhomolog regulates DNA damage response in hepatocellular carcinoma [J]. Sci Rep, 2015, 5: 1-9.
[3] Pang K, Zhang Z, Hao L, et al. The ERH gene regulates migration and invasion in 5637 and T24 bladder cancer cells [J]. BMC Cancer, 2019, 19(1): 225-231.
[4] 庞　昆，郝　林，史振铎，等. 抑制未成熟同源蛋白增强子基因的表达对人膀胱癌T24细胞增殖和凋亡的影响[J]. 肿瘤研究与临床，2018，30（11）：729-734.
[5] Guan X, Zhang C, Zhao J, et al. CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas [J].EBioMedicine, 2018, 35: 233-243.
[6] Weng MT, Luo J. The enigmatic ERH protein: its role in cellcycle, RNA splicing and cancer [J]. Protein Cell, 2013, 4(11): 807-812.
[7] Weng MT, Lee JH, Wei SC, et al. Evolutionary conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells [J]. Proc Natl Acad Sci USA, 2012, 109(52): 3659-3667.
[8] Kavanaugh G, Zhao R, Guo Y, et al. Enhancer of rudimen-tary homolog affects the replication stress response through regulation of RNA processing [J]. Mol Cell Biol, 2015, 35(17): 2979-2990.
[9] Zhang D, Chu YJ, Song KJ, et al. Knockdown of enhancer of rudimentary homolog inhibits proliferation and metastasis inovarian cancer by regulating epithelial-mesenchymal tran-sition [J]. Biomed Pharmacother, 2020, 125: 1-9.
[10] Ishikawa K, Ishikawa A, Shoji Y, et al. A genotoxic stress-responsive miRNA, miR-574-3p, delays cell growth by suppressing the enhancer of rudimentary homolog gene in vitro [J]. Int J Mol Sci, 2014, 15(2): 2971-2990.
[11] Li Q, Wu Q, Li Z, et al. LncRNA LINC00319 is associated with tumorigenesis and poor prognosis in glioma [J]. Eur J Pharmacol, 2019, 861: 1-8.

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更新日期/Last Update: 2020-11-25