参考文献/References:
[1] Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO
classification of tumours of the central nervous system [J].
Acta Neuropathol, 2007, 114(5): 97-109.
[2] Kim JH, Kim H, Lee KY, et al. Genetic polymorphisms of
ataxia telangiectasia mutated affect lung cancer risk [J].
Human Mole Gen, 2006, 15(7): 1181-1186．
[3] Sartor CI. Biological modifiers as potential radiosensitizers:
targeting the epidermal growth factor receptor family [J].
Semin Oncol, 2000, 27(6): 15-20.
[4] Grenbaek K, Worm J, Ralfkiaer E, et al. ATM mutations are
associated with inactivation of the ARF-TP53 tumor sup-
pressor pathway in diffuse large B-cell lymphoma[J]. Blood,
2002, 100(4): 1430-1437.
[5] Kish S, Lu KP. A critical role for Pin2/TRF1 in ATM-
dependent regulation: inhibition of Pin2/TRF1 function
complements telomere shortening, radiosensitivity, and the
G(2)/M checkpoint defect of ataxia-telangiectasia cells [J]. J
Biolo Chemi, 2002, 277(9): 7420-7429.
[6] Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell
survival by phosphorylating and inhibiting a Forkhead tran-
scription factor [J]. Cell , 1999, 96: 857-868.
[7] Saglam O, Garrett CR, Boulware D, et al. Activation of the
serine/threonine protein kinase AKT during the progression
of colorectal neoplasia [J]. Clin Colorectal Cancer, 2007, 6
(9): 652.
[8] Djordjevic S, Driscoll PC. Structural insight into substrate
specificity and regulatory mechanisms of phosphoinositide
3-kinases [J]. Trends Biodmn Sci, 2002, 27:426-432.
[9] Yang ZZ, Tschopp O, Di-Poi N, et al. Dosage-dependent
effects of Akt1/protein kinase B alpha (PKB alpha) and
Akt3/PKB gamma on thymus, skin, and cardiovascular and
nervous system development in mice [J]. Mol Cell Bio1,
2005, 25(23): 10407-10418.
[10] 朱婉儿，胡长春，谢文婷，等. 慢性应激对大鼠海马Akt/
FKHR1信号通路活性的影响[J]. 心理学报，2007，39（4）：
656-661.
[11] Ziegler DS, Kung AL, Kieran MW. Anti-apoptosis mecha-
nisms in malignant gliomas [J]. J Clin Oncol, 2008, 26:
493-500.
[12] 薛 景，刘芬菊. PI3K/Akt与胶质瘤辐射抗性[J]. 国外医
学. 放射医学核医学分册，2005，29（1）：42-43.
[13] Daika GK, Lin SC, Zhao S, et al. DNA damage-induced cell
cycle checkpoints and DNA strand break repair in develop-
ment and tumorigenesis [J]. Oncogene, 1999, 18: 7883-
7899.
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