[1]孙连杰　李　珂　高　峰　董　军　张　诚　麦麦提依明﹒托合提　吴永刚　杨小朋.新疆地区新疆维吾尔族、汉族胶质瘤Ki-67、S-100和GFAP 的表达差异[J].中国临床神经外科杂志,2019,(02):75-77.[doi:10.13798/j.issn.1009-153X.2019.02.004]
　SUN Lian-jie,LI Ke,GAO Feng,et al.Difference of expression of tumor-related markers in gliomas tissues between Uygur and Han nationalities patients with glimas in Xinjiang[J].,2019,(02):75-77.[doi:10.13798/j.issn.1009-153X.2019.02.004]
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新疆地区新疆维吾尔族、汉族胶质瘤Ki-67、S-100和GFAP 的表达差异()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年02期
页码:
75-77
栏目:
论著
出版日期:
2019-02-20

文章信息/Info

Title:
Difference of expression of tumor-related markers in gliomas tissues between Uygur and Han nationalities patients with glimas in Xinjiang
文章编号:
1009-153X（2019）02-0075-03
作者:
孙连杰　李　珂　高　峰　董　军　张　诚　麦麦提依明﹒托合提　吴永刚　杨小朋
832000 新疆石河子，石河子大学医学院研究生院（孙连杰、李　珂）；830001 乌鲁木齐，新疆维吾尔自治区人民医院神经外科（高　峰、董　军、张　诚、麦麦提依明·托合提、吴永刚、杨小朋）
Author(s):
SUN Lian-jie1;  LI Ke1;  GAO Feng2;  DONG Jun2;  ZHANG Cheng2;  Maitiyiming Tohti2;  WU Yong-gang2;  Yang Xiao-peng2.
1. Graduate Intitute, Medical School, Shihezi University; 2. Department Neurosurgery, People’s Hospital, Xinjiang Uygur Autonomous Region, Urumqi 830000, China
关键词:
胶质瘤; 基因表达; Ki-67; S-100; GFAP; 新疆维吾尔族; 汉族
Keywords:
Gliomas;  Glioma-related markers;  Ethnical difference
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2019.02.004
文献标志码:
A
摘要:
目的 比较新疆地区新疆维吾尔族（简称维族）、汉族胶质瘤Ki-67、S-100和GFAP的表达差异。方法 选取新疆维吾尔自治区人民医院神经外科2010年6月至2017年12月收治的经病理明确的胶质瘤260例，其中维族91例（维族组），汉族169例（汉族组）。采用免疫组化Envision法检测两组胶质瘤Ki-67、S-100和胶质纤维酸性蛋白（GFAP）的表达水平。结果 汉族组胶质瘤Ki-67、S-100和GFAP表达阳性率分别为78.7%、74.0%、68.6%；维族组胶质瘤Ki-67、S-100和GFAP表达阳性率分别为81.3%、79.1%、70.3%；两组胶质瘤Ki-67、S-100和GFAP表达阳性率均无统计学差异（P>0.05）。Ki-67表达水平与胶质瘤WHO分级均呈明显正相关（rs汉=0.616，rs维=0.742；P<0.001），而S-100表达水平（rs汉=-0.488，rs维=-0.405；P<0.001）和GFAP表达水平（rs汉=-0.533，rs维=-0.384；P<0.001）均与胶质瘤WHO分级呈明显负相关。结论 尽管Ki-67表达水平与胶质瘤WHO分级均呈明显正相关，S-100和GFAP表达水平与胶质瘤WHO分级呈明显负相关，但我国新疆地区维族和汉族胶质瘤Ki-67、S-100和GFAP表达水平无明显差异。
Abstract:
Objective To compare the expression levels of Ki-67, S-100 and glial fibrillary acidic protein (GFAP) in the gliomas tissues in Xinjiang Uygur and Han patients with astrogliomas. Methods The expression levels of Ki-67, S-100 and GFAP in 260 samples of astrogliomas derived from 91 Uygur and 169 Han patients with astrogliomas were detected by immunohistochemical Envision method. Results The positive rates of Ki-67, S-100 and GFAP in the tumor tissues were 81.32%, 79.12% and 70.33% respectively in 91 Uygur patients with astrocytomas, and were 78.70%, 73.96% and 68.64%, respectively in the Han patients with astrocytomas. There was no significant difference in the positive rates of Ki-67, S-100 and GFAP expressions between the two nationalities patients (P>0.05). The expression level of Ki-67 was positively correlated with the WHO grade of gliomas (rsHan= 0.616, rsUygur=0.742, P<0.001), and the expression level of S-100 (rsHan=-0.488, rsUygur=-0.405, P<0.001) and the expression level of GFAP(rsHan=-0.533, rsUygur=-0.384, P<0.001) were negatively correlated with WHO grade of gliomas. Conclusion It is suggested that the ethnical factor may no effect on the correlativity between the expression level of glioma-related marker including Ki-67, S-100 and GFAP.

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备注/Memo

备注/Memo:
基金项目：新疆维吾尔自治区自然科学基金(2017D01C146)；陈忠平基金会基金项目(CSNO-2016-MSD2016)
作者单位：832000 新疆石河子，石河子大学医学院研究生院（孙连杰、李　珂）；830001 乌鲁木齐，新疆维吾尔自治区人民医院神经外科（高　峰、董　军、张　诚、麦麦提依明·托合提、吴永刚、杨小朋）
通讯作者：杨小朋，E-mail：yxp9972 @sina.com
更新日期/Last Update: 2019-02-20