[1]向 旭 谢 腾 牟 宇 丁 锐 许强华 罗小程 胡 航 陈治军.Cullin7蛋白在人脑胶质瘤中的表达及临床意义[J].中国临床神经外科杂志,2019,(12):746-748.[doi:10.13798/j.issn.1009-153X.2019.12.009]
 XIANG Xu,XIE Teng,MOU Yu,et al.Expression and significance of Cullin7 protein in human gliomas[J].,2019,(12):746-748.[doi:10.13798/j.issn.1009-153X.2019.12.009]
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Cullin7蛋白在人脑胶质瘤中的表达及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年12期
页码:
746-748
栏目:
论著
出版日期:
2019-12-24

文章信息/Info

Title:
Expression and significance of Cullin7 protein in human gliomas
文章编号:
1009-153X(2019)12-0746-03
作者:
向 旭 谢 腾 牟 宇 丁 锐 许强华 罗小程 胡 航 陈治军
448000 湖北,湖北民族大学医学部荆门临床医学院/荆门市第一人民医院神经外科(向 旭、谢 腾、牟 宇、丁 锐、许强华、罗小程、胡 航、陈治军)
Author(s):
XIANG Xu XIE Teng MOU Yu DING Rui XU Qiang-hua LUO Xiao-cheng HU Hang CHEN Zhi-jun. Jingmen Clinical Medical College Hubei Minzu University/Department of Neurosurgery Jingmen Municipal First People's Hospital Jingmen 448000 China
Jingmen Clinical Medical College, Hubei Minzu University/Department of Neurosurgery, Jingmen Municipal First People's Hospital, Jingmen 448000, China
关键词:
胶质瘤Cullin7蛋白基因表达临床意义
Keywords:
Human brain gliomas Cullin7 protein Expression Clinical significance
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2019.12.009
文献标志码:
A
摘要:
目的 探讨Cullin7蛋白在人脑胶质瘤中的表达及临床意义。方法 选取2013年1月至2018年12月手术切除脑胶质瘤标本60例,其中WHO分级Ⅰ级12例,Ⅱ级18例,Ⅲ级14例,Ⅳ级16例。另选取重型颅脑损伤内减压术切除正常脑组织10例作为对照组。采用免疫组化染色、免疫印迹法法检测Cullin7蛋白表达情况。51例随访46个月,9例失访;采用Kaplan-Meir法分析和Log-rank检验分析生存曲线。结果 高级别胶质瘤Cullin7蛋白阳性表达率(66.7%)明显高于低级别胶质瘤(36.7%;P<0.05),而低级别胶质瘤Cullin7蛋白阳性表达率明显高于对照组(0%;P<0.05)。Cullin7高表达病人生存期较低表达病人明显缩短(P<0.05)。结论 Cullin7蛋白在脑胶质瘤中的表达与肿瘤恶性程度呈正相关,与病人生存期呈负相关。
Abstract:
Objective To investigate the expression and significance of Cullin7 in human brain gliomas. Methods The expression of Cullin7 protein was determined by immunohistochemical technique and Western blot in 60 samples of gliomas, of which, 12 belonged in WHO grade Ⅰ, 18 gradeⅡ, 14 grade Ⅲ and 16 gradeⅣ gained from the patients with gliomas undergoing neurosurgery in our hospital from 2013 to 2018, and 10 normal cerebral tissues gained from patients with severe traumatic brain injury undergoing internal decompression. The relationship of the survival time with the expression of Cullin7 in the gliomas tissues was analyzed in the patients with different WHO grades of gliomas. Results The level of Cullin7 protein expression was significantly higher in the gliomas tissues than that in normal brain tissues (P<0.05), and the level of Cullin7 protein expression was significantly higher in the high-grade gliomas (WHO grades Ⅲ~Ⅳ) tissues than that in the low-grade gliomas (WHO grades Ⅰ~Ⅱ) tissues (P<0.05). The Survival time of patients with high expression of Cullin7 was significantly shorter than those with low expression of Cullin7 (P<0.05). Conclusion The expression of Cullin7 protein in the gliomas tissues was positively correlated with tumor malignancy and negatively correlated with the survival time in the patients with brain gliomas.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:湖北省自然科学基金(2018CFB784);湖北省卫生健康委员会面上项目(WJ2019M076);2019年度荆门市科技计划重点项目 通讯作者:陈治军,E-mail:13807268870@163.com (2019-05-29收稿,2019-08-03修回)
更新日期/Last Update: 2019-12-23